Title: Synthesis of 1′-substituted 4′,4′-dimethyl-6′-methoxy-4′ H-spiro[cyclohexane-1,3′-isoquinolines].
Authors: Perevoshchikova, A.; Gorbunov, A.; Rozhkova, Yu.; Slepukhin, P.; Shklyaev, Yu.
Abstract: The reaction of 1-(4-methoxyphenyl)-1-(1-methylcyclohexyl)ethanol with nitriles in concentrated sulfuric acid afforded 1′-substituted 6′-methoxy-4′,4′-dimethyl-4′ H-spiro[cyclohexane-1,3′-isoquinolines] as a result of consecutive Wagner-Meerwein rearrangement and Ritter reaction.
Subjects: NITRILES; SULFURIC acid; CYCLOHEXANE; CHEMICAL reactions; ORGANIC chemistry
Publication: Russian Journal of Organic Chemistry, 2014, Vol 50, Issue 4, p513
ISSN: 1070-4280
Publication type: Academic Journal
DOI: 10.1134/S1070428014040125

Synthesis of 1′-substituted 4′,4′-dimethyl-6′-methoxy-4′ H-spiro[cyclohexane-1,3′-isoquinolines].

Perevoshchikova, A.; Gorbunov, A.; Rozhkova, Yu.; Slepukhin, P.; Shklyaev, Yu.