Title: Base-catalyzed heterocyclization of 2-(R-ethynyl)benzohydroxamic acids.
Authors: Vasilevskii, S.; Mikhailovskaya, T.; Stepanov, A.; Mamatyuk, V.; Fadeev, D.
Abstract: Sonogashira alkynylation of methyl 2-iodobenzoate with terminal acetylenes gave a series of methyl 2-(alk-1-yn-1-yl)benzoates which reacted with hydroxylamine in boiling methanol to produce five- or six-membered N-hydroxy lactams, 3-R-methylidene-2-hydroxy-2,3-dihydroisoindol-1-ones or 3-R-isoquinolin-1(2 H)-ones, depending on the acetylenic substituent nature.
Subjects: SONOGASHIRA reaction; CONDENSATION reactions; ACETYLENE; METHANOL; ORGANIC chemistry
Publication: Russian Journal of Organic Chemistry, 2014, Vol 50, Issue 4, p506
ISSN: 1070-4280
Publication type: Academic Journal
DOI: 10.1134/S1070428014040101

Base-catalyzed heterocyclization of 2-(R-ethynyl)benzohydroxamic acids.

Vasilevskii, S.; Mikhailovskaya, T.; Stepanov, A.; Mamatyuk, V.; Fadeev, D.