Title: Synthesis and Biological Activity of Thioethers Containing 1,2,4-Oxadiazole Fragment and Their Oxidation Products.
Authors: Vasilieva, E. A.; Proskurina, I. K.; Kotov, A. D.; Sidorenko, E. O.; Yablokova, L. M.; Korsakov, M. K.; Ivanovskii, S. A.
Abstract: Methods were developed for the synthesis of a series of new thioethers, interesting for medical chemistry, by reacting 4-fluorothiophenol, 2-mercaptobenzoxazole and 5-methoxy-2-mercaptobenzimidazole with 3-aryl-5-(chloromethyl)-1,2,4-oxadiazoles. The conditions for the oxidation of the obtained thioethers into the corresponding sulfones were selected. Analysis of the results of screening of the prepared derivatives against sensitive strains of Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, Bacillus cereus and Candida albicans showed the presence of high and moderate antibacterial activity in a number of compounds in drug concentrations up to 250 μg/mL.
Subjects: CLINICAL chemistry; PSEUDOMONAS fluorescens; BIOSYNTHESIS; DOSAGE forms of drugs; SULFIDES
Publication: Russian Journal of General Chemistry, 2025, Vol 95, Issue 1, p35
ISSN: 1070-3632
Publication type: Academic Journal
DOI: 10.1134/S107036322461189X

Synthesis and Biological Activity of Thioethers Containing 1,2,4-Oxadiazole Fragment and Their Oxidation Products.

Vasilieva, E. A.; Proskurina, I. K.; Kotov, A. D.; Sidorenko, E. O.; Yablokova, L. M.; Korsakov, M. K.; Ivanovskii, S. A.