Title: Relationship Between the Volume of Benzyl Substituent in Isatin-3-acylhydrazones and Their Antimicrobial Activity.
Authors: Bogdanov, A. V.; Voloshina, A. D.; Khamatgalimov, A. R.; Rakhmatullin, R. R.; Samorodov, A. V.; Valiullina, Z. A.; Mironov, V. F.
Abstract: Water-soluble ammonium salts were prepared by the reaction of new sterically hindered isatin derivatives with analogues of Girard's reagents. The resulting isatin-3-hydrazones exhibit high antimicrobial and antiaggregation activity with low hemotoxicity. The dependence of physiological activity on the volume of the benzyl substituent was established.
Subjects: ANTI-infective agents; ISATIN; AMMONIUM salts
Publication: Russian Journal of General Chemistry, 2024, Vol 94, Issue 4, p878
ISSN: 1070-3632
Publication type: Academic Journal
DOI: 10.1134/S1070363224040157

Relationship Between the Volume of Benzyl Substituent in Isatin-3-acylhydrazones and Their Antimicrobial Activity.

Bogdanov, A. V.; Voloshina, A. D.; Khamatgalimov, A. R.; Rakhmatullin, R. R.; Samorodov, A. V.; Valiullina, Z. A.; Mironov, V. F.