Development of Doxorubicin Complex with Nanoparticles Based on Sodium Alginate and Viologen Calix[4]resorcinol to Enhance Selectivity of the Cytotoxic Action.

Kashapov, R. R.; Razuvayeva, Yu. S.; Ziganshina, A. Yu.; Sapunova, A. S.; Voloshina, A. D.; Salnikov, V. V.; Zakharova, L. Ya.

A biocompatible supramolecular system based on sodium alginate and viologen calix[4]resorcinol for encapsulation of doxorubicin hydrochloride (DOX) has been obtained. Using a set of physicochemical methods, the polymer–macrocycle ratio, at which stable nanoparticles are formed, has been found and their morphological characteristics have been determined. It has been shown that the increase in the concentration of calix[4]resorcinol leads to the increase in the size of nanoparticles, their zeta potential being changed from negative to positive values. It has been established that the optimal supramolecular system for DOX binding is a composition with a macrocycle–polymer ratio of 1 : 50, and a change in the components ratio can induce the drug release. The effect of encapsulated DOX on the physicochemical and biological properties of the supramolecular system has been shown.

RESORCINOL; SODIUM alginate; DOXORUBICIN; NANOPARTICLES; NANOPARTICLE size; ZETA potential

Russian Journal of General Chemistry, 2023, Vol 93, Issue 6, p1409

1070-3632

Academic Journal

10.1134/S1070363223060129