Title: Biocompatible Microemulsions Based on Oleic Acid Modified with Piperidinium Surfactants.
Authors: Mirgorodskaya, A. B.; Kushnazarova, R. A.; Lenina, O. A.; Petrov, K. A.; Zakharova, L. Ya.
Abstract: A series of microemulsions based on oleic acid and Tween 80, modified with piperidinium surfactants, have been obtained and characterized. The effect of additives on the size, stability, and solubilization effect of the formed systems with respect to hydrophilic (rhodamine B) and hydrophobic (indomethacin) substances have been investigated. Varying of the components ratio has allowed preparation of the microemulsions with strongly different viscosity: from easy-flowing formulations to gels. Kinetic parameters describing release of the substrates from the microemulsions have been obtained. In vivo tests of the anti-inflammatory action of the microemulsions loaded with indomethacin have shown that the presence of piperidinium surfactants enhances the therapeutic effect of the drug.
Subjects: MICROEMULSIONS; OLEIC acid; SURFACE active agents; RHODAMINE B; SOLUBILIZATION; PHARMACODYNAMICS; IN vivo studies
Publication: Russian Journal of General Chemistry, 2023, Vol 93, Issue 3, p593
ISSN: 1070-3632
Publication type: Academic Journal
DOI: 10.1134/S1070363223030167

Biocompatible Microemulsions Based on Oleic Acid Modified with Piperidinium Surfactants.

Mirgorodskaya, A. B.; Kushnazarova, R. A.; Lenina, O. A.; Petrov, K. A.; Zakharova, L. Ya.