Title: Reaction of Methyl (2-Methylidene)-3-oxolup-20(29)-en-28-oate with Dimethyl Trimethylsilyl Phosphite.
Authors: Tsepaeva, O. V.; Nemtarev, A. V.; Abdullin, T. I.; Kuznetsova, E. V.; Mironov, V. F.
Abstract: A method of phosphorylation of pentacyclic triterpenoids derivatives containing an α,β-unsaturated carbonyl fragment in the ring A was described by the example of the reaction of methyl (2-methylidene)-3-oxolup-20(29)-en-28-oate with dimethyl trimethylsilyl phosphite. Methyl 2-dimethoxyphosphorylmethyl-3-oxolup-20(29)-en-28-oate was obtained as two epimers in a 2: 1 ratio in a 70% yield.
Subjects: TRITERPENOIDS; PHOSPHORYLATION; EPIMERIZATION; CELL-mediated cytotoxicity; DIASTEREOISOMERS
Publication: Russian Journal of General Chemistry, 2018, Vol 88, Issue 9, p1944
ISSN: 1070-3632
Publication type: Academic Journal
DOI: 10.1134/S1070363218090335

Reaction of Methyl (2-Methylidene)-3-oxolup-20(29)-en-28-oate with Dimethyl Trimethylsilyl Phosphite.

Tsepaeva, O. V.; Nemtarev, A. V.; Abdullin, T. I.; Kuznetsova, E. V.; Mironov, V. F.