Aggregation Capacity and Complexation Properties of a System Based on an Imidazole-Containing Amphiphile and Bovine Serum Albumin.

Samarkina, D.; Gabdrakhmanov, D.; Lukashenko, S.; Khamatgalimov, A.; Zakharova, L.

A complex of physicochemical methods was used to study the aggregation characteristics of an imidazolium-containing amphiphile and its ability for complex formation with bovine serum albumin (BSA). Tensiometry showed that adding BSA to the surfactant decreases the aggregation threshold of the system by a factor of 50. Dynamic light scattering established, that the size of the surfactant-BSA complexes depends on the size of the polypeptide (6-10 nm) and is independent on the concentrations of the surfactant and BSA. The Stern-Volmer constants and surfactant-protein binding constants were calculated from fluorescence spectroscopy data.

IMIDAZOLES; AMPHIPHILE synthesis; SERUM albumin; CHEMICAL synthesis; AMPHIPHILES; SERUM

Russian Journal of General Chemistry, 2017, Vol 87, Issue 12, p2826

1070-3632

Academic Journal

10.1134/S1070363217120118