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- Title
Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives.
- Authors
Meerovich, I.; Sanarova, E.; Meerovich, G.; Derkacheva, V.; Volkov, K.; Negrimovsky, V.; Barkanova, S.; Lukyanets, E.; Oborotova, N.; Smirnova, Z.; Borisova, L.; Lantsova, A.; Polozkova, A.; Orlova, O.; Loschenov, V.; Umnova, L.; Baryshnikov, A.; Vorozhtsov, G.
- Abstract
The research is devoted to development and study of photosensitizers on a base of injectable nanoparticular formulations of phthalocyanine derivatives absorbing at long wavelength (near-infrared) range of 710-740 nm: Thiosens [liposomal form of aluminum hydroxide 1,8,15,22-tetrakis(phenylsulfanyl)phthalocyanine] and Octasens [polymeric micellar form of zinc 1,4,8,11,15,18,22,25-octachloro-2,3,9,10,16,17,23,24-octakis-(decylsulfanyl)phthalocyanine based on domestic poloxamer Emuxol-268]. Experiments have shown that the photosensitizers under study show high selectivity of accumulation and prolonged retaining at high concentration in tumor, relatively fast clearance from normal tissue and high therapeutic efficiency of photodynamic treatment on model tumors.
- Subjects
PHOTOSENSITIZERS; NANOSTRUCTURED materials; PHTHALOCYANINE derivatives; POLOXAMERS; TUMORS; TUMOR treatment; PHOTODYNAMIC therapy
- Publication
Russian Journal of General Chemistry, 2015, Vol 85, Issue 1, p280
- ISSN
1070-3632
- Publication type
Academic Journal
- DOI
10.1134/S1070363215010430