Title: Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives.
Authors: Meerovich, I.; Sanarova, E.; Meerovich, G.; Derkacheva, V.; Volkov, K.; Negrimovsky, V.; Barkanova, S.; Lukyanets, E.; Oborotova, N.; Smirnova, Z.; Borisova, L.; Lantsova, A.; Polozkova, A.; Orlova, O.; Loschenov, V.; Umnova, L.; Baryshnikov, A.; Vorozhtsov, G.
Abstract: The research is devoted to development and study of photosensitizers on a base of injectable nanoparticular formulations of phthalocyanine derivatives absorbing at long wavelength (near-infrared) range of 710-740 nm: Thiosens [liposomal form of aluminum hydroxide 1,8,15,22-tetrakis(phenylsulfanyl)phthalocyanine] and Octasens [polymeric micellar form of zinc 1,4,8,11,15,18,22,25-octachloro-2,3,9,10,16,17,23,24-octakis-(decylsulfanyl)phthalocyanine based on domestic poloxamer Emuxol-268]. Experiments have shown that the photosensitizers under study show high selectivity of accumulation and prolonged retaining at high concentration in tumor, relatively fast clearance from normal tissue and high therapeutic efficiency of photodynamic treatment on model tumors.
Subjects: PHOTOSENSITIZERS; NANOSTRUCTURED materials; PHTHALOCYANINE derivatives; POLOXAMERS; TUMORS; TUMOR treatment; PHOTODYNAMIC therapy
Publication: Russian Journal of General Chemistry, 2015, Vol 85, Issue 1, p280
ISSN: 1070-3632
Publication type: Academic Journal
DOI: 10.1134/S1070363215010430

Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives.

Meerovich, I.; Sanarova, E.; Meerovich, G.; Derkacheva, V.; Volkov, K.; Negrimovsky, V.; Barkanova, S.; Lukyanets, E.; Oborotova, N.; Smirnova, Z.; Borisova, L.; Lantsova, A.; Polozkova, A.; Orlova, O.; Loschenov, V.; Umnova, L.; Baryshnikov, A.; Vorozhtsov, G.