Title: Pyrimidinophane p-toluenesulfonate—Water-soluble pyrimidine-containing macrocycles.
Authors: Semenov, V. E.; Mikhailov, A. S.; Romanova, E. S.; Voloshina, A. D.; Kulik, N. V.; Uraleva, S. Yu.; Kozlov, A. V.; Latypov, Sh. K.; Reznik, V. S.
Abstract: Reactions of pyrimidinophanes containing two 6-methylthiocytosine and one 6-methyluracil fragments with methyl p-toluenesulfonate gave amphiphilic macrocyclic bis- p-toluenesulfonates. Despite the presence of several reaction centers in the initial pyrimidinophane molecules, methylation occurred only at the N1 atom (with quaternization) of the 6-methylthiocytosine fragments. Bacteriostatic and fungistatic activity of the products was estimated.
Subjects: PHYSICAL & theoretical chemistry; PYRIMIDINES; MOLECULES; METHYLATION; ANTIBACTERIAL agents; MACROCYCLIC compounds
Publication: Russian Journal of General Chemistry, 2009, Vol 79, Issue 1, p134
ISSN: 1070-3632
Publication type: Academic Journal
DOI: 10.1134/S1070363209010216

Pyrimidinophane p-toluenesulfonate—Water-soluble pyrimidine-containing macrocycles.

Semenov, V. E.; Mikhailov, A. S.; Romanova, E. S.; Voloshina, A. D.; Kulik, N. V.; Uraleva, S. Yu.; Kozlov, A. V.; Latypov, Sh. K.; Reznik, V. S.