Title: Synthesis of acyclic and macrocyclic analogs of Di-, Tri-, and tetranucleotides.
Authors: Semenov, V. E.; Akamsin, V. D.; Reznik, V. S.
Abstract: Compounds consisting of two or three uracil fragments were synthesized by reaction of methyl-substituted uracil sodium salts with 1-(6-bromohexyl)-3,6-dimethyluracil or 1,6-dibromohexane. Treatment of these compounds with paraformaldehyde gave the corresponding pyrimidinophanes and acyclic compounds in which the uracil fragments are linked through methylene bridges. Uracil derivatives having no substituent on N3 were synthesized by reactions of silylated uracils with 1,3-bis(6-bromohexyl)uracil or 4,4′-(6-bromohexyloxy)diphenylmethane. The acyclic compound was converted into pyrimidinophane containing uracil fragments with N3H groups. A trinucleotide analog including uracil and two adenine fragments was synthesized from 1,3-bis(6-bromohexyl)uracil.
Subjects: URACIL; HETEROCYCLIC compounds; PYRIMIDINES; CARBENES; ADENINE
Publication: Russian Journal of General Chemistry, 2007, Vol 77, Issue 8, p1430
ISSN: 1070-3632
Publication type: Academic Journal
DOI: 10.1134/S1070363207080233

Synthesis of acyclic and macrocyclic analogs of Di-, Tri-, and tetranucleotides.

Semenov, V. E.; Akamsin, V. D.; Reznik, V. S.