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Title: Supramolecular Systems of Metal Complexes of 1-Cetyl-4-aza-1-azoniabicyclo[2,2,2]octane Bromide for Increasing Griseofulvin Solubility.
Authors: Ibatullina, M. R.; Zhil'tsova, E. P.; Lukashenko, S. S.; Zakharova, L. Ya.
Abstract: Spectrophotometry has been employed to study the effect of metal-containing micellar systems of alkylated 1,4-diazabicyclo[2,2,2]octane complexes with Cu(II) and La(III) nitrates on the solubility of an antifungal drug, griseofulvin. The solubilization capacity of the aggregates of the metal complexes with respect to griseofulvin is 2 times as high as that of the ligand and up to two to three times as high as that of cetyltrimethylammonium bromide and its mixtures with corresponding inorganic salts. UV spectroscopy and dynamic light scattering studies have shown that the presence of the solubilizate causes alterations in the aggregation characteristics of the amphiphilic compounds, namely, a decrease in the aggregation threshold and variations in the sizes of the associates.
Subjects: METAL complexes; GRISEOFULVIN; SOLUBILITY; AMPHIPHILES; CETYLTRIMETHYLAMMONIUM bromide; SOLUBILIZATION; AZA compounds
Publication: Colloid Journal, 2020, Vol 82, Issue 1, p8
ISSN: 1061-933X
Publication type: Academic Journal
DOI: 10.1134/S1061933X20010068

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Supramolecular Systems of Metal Complexes of 1-Cetyl-4-aza-1-azoniabicyclo[2,2,2]octane Bromide for Increasing Griseofulvin Solubility.