Pilot Study to Detect the Repertoires of T-Cell Receptor Gamma Chains in Patients with Juvenile Schizophrenia.

Plotnikova, M. Yu.; Patrikeev, A. D.; Levchenko, A. Yu.; Fedorenko, O. Yu.; Andreeva, T. V.; Rogaev, E. I.

Disfunction of the immune system and neuroinflammation may play a role in the pathogenesis of schizophrenia. The role of the adaptive immune system has to be elucidated. We present a pilot study to test the methodology of profiling immune repertoires of the TCR gamma chain by deep sequencing using several patients with juvenile schizophrenia and unaffected control subjects. The clonotype profiles were revealed, and their diversity and presumable differences in the structure of the CDR3 TRG region of functional clones in juvenile schizophrenia and controls were assessed. This approach is promising for further comprehensive study of changes in the adaptive immune system in representative cohorts of patients with different forms of schizophrenia.

FUNCTIONAL regions; PEOPLE with schizophrenia; T cell receptors; PILOT projects; IMMUNE system; SCHIZOPHRENIA; T cells

Russian Journal of Genetics, 2023, Vol 59, Issue 7, p739

1022-7954

Academic Journal

10.1134/S1022795423070086