Results
Title

Mitochondrial DNA Mutations in Cardiovascular Diseases.

Authors

Korepanov, V. A.; Rebrova, T. Y.; Batalov, R. E.; Afanasiev, S. A.

Abstract

Early prevention of the development and timely diagnosis of cardiovascular system diseases are some of the main problems in modern cardiology. One promising approach is to identify relationships between carriage of mitochondrial DNA (mtDNA) mutations and development of cardiovascular diseases. Mitochondria are the only source of energy accumulation in cardiomyocytes; therefore, failure of their functioning caused by mtDNA mutations directly affects the bioenergetics and work of myocardial cells. The objective of this review is to describe the current achievements in studying the relationships of mutant mtDNA with the development of various cardiovascular system diseases.

Subjects

MITOCHONDRIAL DNA; CARDIOVASCULAR diseases; CARDIOVASCULAR disease diagnosis; MITOCHONDRIAL pathology; PERFORMANCE in children; CARDIOVASCULAR development; BIOENERGETICS; MITOCHONDRIA

Publication

Russian Journal of Genetics, 2023, Vol 59, Issue 7, p637

ISSN

1022-7954

Publication type

Academic Journal

DOI

10.1134/S1022795423070062