One of the most important traits in plant domestication and breeding is the stem growth habit, which can be determinate (terminated) or indeterminate (not terminated). Some taxa have a semideterminate stem growth habit. In different crops preference can be given to cultivars with different stem growth habits. Because of this, among angiosperms for this trait, pronounced homologous series in hereditary variability are observed. The review considers molecular genetic mechanisms controlling the stem growth habit in dicotyledonous and monocotyledonous plants, which underlie phenotypic variation. Data on the known homologs of the ArabidopsisTFL1 gene are presented. Comparison of modern data on the genetic control of stem growth habit in the representatives of different taxa of angiosperms points to the evolutionary conservation of molecular genetic mechanisms controlling the initiation of flowering, as well as to the conserved functionality of the genes involved in this process.