cytogenetic study of eight natural populations of Anopheles messeae from the north-eastern part of the species areal was conducted. Complete predominance of homozygotes XL and 3R in the northern populations was observed. Change in the chromosome 2 inversion frequencies from south northwards was shown. The 2R variant, which was not observed in the southern region, was found in the northern populations. These results indicate the maintenance of chromosome frequency of the distribution of inversions XL and 3R (in longitude) and 2R (in latitude). The inversion frequency distribution in the examined part of the areal have been preserved for a long time.