Title: Age-Related Dynamics of Insulin Signaling in Neurons of the Rat Hypothalamic Tuberal Nuclei.
Authors: Anfimova, P. A.; Porseva, V. V.; Pankrasheva, L. G.; Shirina, E. S.; Masliukov, P. M.
Abstract: The hypothalamus is a regulatory center that controls homeostasis, reproduction, circadian rhythms, and the endocrine system. It is also involved in the regulation of aging. The expression of insulin receptors (INR) and insulin receptor substrate 1 (IRS1) was studied in neurons of the arcuate (ARN), dorsomedial (DMN), and ventromedial (VMN) tuberal nuclei of the rat hypothalamus in young (2 months), adult (12 months), and old (24 months) male Wistar rats using immunofluorescence staining and Western blotting. The results showed that INR and IRS1 expression in neurons of the mediobasal hypothalamic nuclei changes in opposite directions with age. INR expression decreases in the ARN and increases in the DMN and VMN, while IRS1 expression is unchanged in the ARN and VMN and decreases in the DMN.
Subjects: HYPOTHALAMUS; INSULIN receptors; ENDOCRINE system; NEURONS; INSULIN; LABORATORY rats; MOLECULAR clock
Publication: Journal of Evolutionary Biochemistry & Physiology, 2024, Vol 60, Issue 2, p829
ISSN: 0022-0930
Publication type: Academic Journal
DOI: 10.1134/S0022093024020303

Age-Related Dynamics of Insulin Signaling in Neurons of the Rat Hypothalamic Tuberal Nuclei.

Anfimova, P. A.; Porseva, V. V.; Pankrasheva, L. G.; Shirina, E. S.; Masliukov, P. M.