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- Title
On the Effect of the Nature of Substituents on the Antimicrobial Activity of Water-Soluble Acylhydrazones on the Isatin Scaffold.
- Authors
Bogdanov, A. V.; Voloshina, A. D.; Khamatgalimov, A. R.; Terekhova, N. V.; Mironov, V. F.
- Abstract
The dependence of the level of antimicrobial activity of some ammonium isatin-3-acylhydrazones on the sterical hindrance and electronic nature of substituents in the benzyl moiety was elucidated using simple molecular descriptors and quantum chemical calculations. The structure and electronic nature of substituents in position 1 and the lipophilicity of compounds of this series were shown to be the key factors determining the activity.
- Subjects
ISATIN; ELECTRONIC structure; MOIETIES (Chemistry); LIPOPHILICITY
- Publication
Doklady Chemistry, 2020, Vol 494, Issue 1, p136
- ISSN
0012-5008
- Publication type
Academic Journal
- DOI
10.1134/S0012500820090013