On the Effect of the Nature of Substituents on the Antimicrobial Activity of Water-Soluble Acylhydrazones on the Isatin Scaffold.

Bogdanov, A. V.; Voloshina, A. D.; Khamatgalimov, A. R.; Terekhova, N. V.; Mironov, V. F.

The dependence of the level of antimicrobial activity of some ammonium isatin-3-acylhydrazones on the sterical hindrance and electronic nature of substituents in the benzyl moiety was elucidated using simple molecular descriptors and quantum chemical calculations. The structure and electronic nature of substituents in position 1 and the lipophilicity of compounds of this series were shown to be the key factors determining the activity.

ISATIN; ELECTRONIC structure; MOIETIES (Chemistry); LIPOPHILICITY

Doklady Chemistry, 2020, Vol 494, Issue 1, p136

0012-5008

Academic Journal

10.1134/S0012500820090013