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Title: Prolactin Receptor Isoforms as the Basis of Tissue-Specific Action of Prolactin in the Norm and Pathology.
Authors: Abramicheva, P. A.; Smirnova, O. V.
Abstract: The review describes functional and structural features of different isoforms of prolactin receptor, mechanisms of signaling pathway activation, and molecular messengers involved in the transmission and termination of signal from the prolactin receptor isoforms. Changes in the ratio between prolactin receptor isoforms, key mediators of prolactin signal transduction and termination in various organs and tissues, are analyzed. Special attention is given to the role of molecular mediators and the ratio between the isoforms in normal physiological functions and pathologies. Approaches for therapeutic correction of prolactin signaling impairments are discussed.
Subjects: PROLACTIN; CELLULAR signal transduction; STAT proteins; PATHOLOGY; SUPPRESSORS of cytokine signaling
Publication: Biochemistry (00062979), 2019, Vol 84, Issue 4, p329
ISSN: 0006-2979
Publication type: Academic Journal
DOI: 10.1134/S0006297919040011

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Prolactin Receptor Isoforms as the Basis of Tissue-Specific Action of Prolactin in the Norm and Pathology.