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Title: Separation and study of the range of plasminogen isoforms in patients with prostate cancer.
Authors: Shin, E.; Vodolazhsky, D.; Golikov, A.; Belova, T.; Boyko, N.; Zimakov, D.; Cherkasova, E.; Kogan, M.; Chibichian, M.; Moshkovskii, S.; Tarasov, V.; Matishov, D.
Abstract: Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and higher p I values compared to isoforms found in the control group.
Subjects: SEPARATION (Technology); PLASMINOGEN; PROSTATE cancer patients; AFFINITY chromatography; TWO-dimensional electrophoresis; BLOOD plasma; MOLECULAR weights
Publication: Biochemistry (00062979), 2012, Vol 77, Issue 9, p1065
ISSN: 0006-2979
Publication type: Academic Journal
DOI: 10.1134/S0006297912090143

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Separation and study of the range of plasminogen isoforms in patients with prostate cancer.