In proton-nucleus reactions, the ratios of the cross sections for 18 isomeric pairs were measured by the induced-activity method as functions of the initial-proton energy and of the number of emitted nucleons. The isotopic effect and the cross sections for charge-exchange reactions are discussed. The experimental values of the cross sections for disintegration reactions like (p, xpyn) are compared with the theoretical values calculated on the basis of the cascade-evaporation model.