Works matching DNA alkylation
Results: 375
Archaeal DNA alkylation repair conducted by DNA glycosylase and methyltransferase.
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- Applied Microbiology & Biotechnology, 2023, v. 107, n. 10, p. 3131, doi. 10.1007/s00253-023-12506-3
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Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-59072-6
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Sequence-Specific DNA Alkylation by Tandem Py-Im Polyamide Conjugates.
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- Chemistry - An Asian Journal, 2014, v. 9, n. 9, p. 2527, doi. 10.1002/asia.201402331
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Versatile cell-based assay for measuring DNA alkylation damage and its repair.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-97523-w
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DNA Polymerases ImuC and DinB Are Involved in DNA Alkylation Damage Tolerance in Pseudomonas aeruginosa and Pseudomonas putida.
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- PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0170719
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DNA Alkylation Damage by Nitrosamines and Relevant DNA Repair Pathways.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 5, p. 4684, doi. 10.3390/ijms24054684
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Interdependent Sequence Selectivity and Diastereoselectivity in the Alkylation of DNA by Decarbamoylmitomycin C.
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- Chemistry - A European Journal, 2018, v. 24, n. 50, p. 13278, doi. 10.1002/chem.201802038
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Synthesis and in vitro anticancer evaluation of 1,8-naphthalimide N(4) and S(4)-derivatives combining DNA intercalation and alkylation capabilities.
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- Research on Chemical Intermediates, 2016, v. 42, n. 3, p. 1741, doi. 10.1007/s11164-015-2115-1
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Development of the adverse outcome pathway 'alkylation of DNA in male premeiotic germ cells leading to heritable mutations' using the OECD's users' handbook supplement.
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- Environmental & Molecular Mutagenesis, 2015, v. 56, n. 9, p. 724, doi. 10.1002/em.21954
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Analysis of DNA alkylation damage and repair in mammalian cells by the comet assay.
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- Mutagenesis, 1996, v. 11, n. 2, p. 169, doi. 10.1093/mutage/11.2.169
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Preliminary study of mechanism of action of SN38 derivatives. Physicochemical data, evidence of interaction and alkylation of DNA octamer d(GCGATCGC)<sub>2</sub>.
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- Magnetic Resonance in Chemistry, 2017, v. 55, n. 2, p. 128, doi. 10.1002/mrc.4508
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Sequence selectivity of azinomycin B in DNA alkylation and cross-linking: a QM/MM study.
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- Journal of Molecular Modeling, 2013, v. 19, n. 1, p. 383, doi. 10.1007/s00894-012-1557-2
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Synthesis of Various Water Soluble and Stable Copper Complexes Bearing N‐Heterocyclic Carbene Ligands and Their Activity in DNA Alkylation.
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- Helvetica Chimica Acta, 2019, v. 102, n. 1, p. N.PAG, doi. 10.1002/hlca.201800183
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Protein Recognition in Drug-Induced DNA Alkylation: When the Moonlight Protein GAPDH Meets S23906-1/DNA Minor Groove Adducts.
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- International Journal of Molecular Sciences, 2015, v. 16, n. 11, p. 26555, doi. 10.3390/ijms161125971
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Evaluation of the DNA Alkylation Properties of a Chlorambucil‐Conjugated Cyclic Pyrrole‐Imidazole Polyamide.
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- Chemistry - A European Journal, 2021, v. 27, n. 8, p. 2782, doi. 10.1002/chem.202004421
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REV1 coordinates a multi-faceted tolerance response to DNA alkylation damage and prevents chromosome shattering in Drosophila melanogaster.
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- PLoS Genetics, 2024, v. 20, n. 7, p. 1, doi. 10.1371/journal.pgen.1011181
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Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes.
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- PLoS Biology, 2017, v. 15, n. 11, p. 1, doi. 10.1371/journal.pbio.2002810
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Sequence-Specific DNA Alkylation Targeting for Kras Codon 13 Mutation by Pyrrole–Imidazole Polyamide seco-CBI Conjugates.
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- Chemistry - A European Journal, 2014, v. 20, n. 5, p. 1310, doi. 10.1002/chem.201303295
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"Repaired and Activated" DNAzyme Enables the Monitoring of DNA Alkylation Repair in Live Cells.
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- Angewandte Chemie, 2021, v. 133, n. 36, p. 20042, doi. 10.1002/ange.202106557
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Mutagenicity and toxicity of the DNA alkylation carcinogens 1, 2-dimethylhydrazine and azoxymethane in Escherichia coli and Salmonella typhimurium.
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- Mutagenesis, 1996, v. 11, n. 3, p. 241, doi. 10.1093/mutage/11.3.241
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DNA Alkylation of the RUNX‐Binding Sequence by CBI–PI Polyamide Conjugates**.
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- Chemistry - A European Journal, 2020, v. 26, n. 64, p. 14639, doi. 10.1002/chem.202002166
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<i>Pseudomonas putida</i> AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA – <i>In Vivo</i>, <i>In Vitro</i>, and <i>In Silico</i> Studies.
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- PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076198
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Inhibition of DNA alkylation damage with inorganic salts.
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- Journal of Biological Inorganic Chemistry (JBIC), 2004, v. 9, n. 7, p. 894, doi. 10.1007/s00775-004-0597-1
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Sequence selectivity of DNA alkylation by adozelesin and carzelesin.
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- Archives of Pharmacal Research, 1998, v. 21, n. 4, p. 385, doi. 10.1007/BF02974631
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Dual-Action Therapeutics: DNA Alkylation and Antimicrobial Peptides for Cancer Therapy.
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- Cancers, 2024, v. 16, n. 18, p. 3123, doi. 10.3390/cancers16183123
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DNA alkylation and neuro-oncogenesis by 3,3-dimethyl-1-phenyltriazene.
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- Acta Neuropathologica, 1978, v. 43, n. 1/2, p. 105, doi. 10.1007/BF00685004
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Alkylation and Cleavage of a DNA Fragment with Trioligonucleotide Reagent.
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- Nucleosides, Nucleotides & Nucleic Acids, 2004, v. 23, n. 6/7, p. 825, doi. 10.1081/NCN-200026023
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Activation barriers for DNA alkylation by carcinogenic methane diazonium ions.
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- Journal of Computational Chemistry, 2006, v. 27, n. 3, p. 277, doi. 10.1002/jcc.20334
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2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV).
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- Molbank, 2012, v. 12, n. 4, p. 1, doi. 10.3390/M781
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2-[3-(Aziridin-1-yl)-2-hydroxypropyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part III).
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- Molbank, 2012, v. 12, n. 3, p. 1, doi. 10.3390/M772
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Synthesis of 2‐Chloro‐3‐amino indenone derivatives and their evaluation as inhibitors of DNA dealkylation repair.
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- Chemical Biology & Drug Design, 2021, v. 97, n. 6, p. 1170, doi. 10.1111/cbdd.13839
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Insight Into Factors Governing Formation, Synthesis and Stereochemical Configuration of DNA Adducts Formed by Mitomycins.
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- Chemical Record, 2023, v. 23, n. 1, p. 1, doi. 10.1002/tcr.202200193
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Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1.
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- PLoS Genetics, 2013, v. 9, n. 4, p. 1, doi. 10.1371/journal.pgen.1003413
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Hoogsteen Base Pairings: A New Paradigm for DNA Replication, DNA Recognition, and DNA Repair.
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- Journal of Experimental & Molecular Biology, 2022, v. 23, n. 1, p. 78, doi. 10.47743/jemb-2022-72
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The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.
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- Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19221-x
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Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.
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- Nature Chemical Biology, 2006, v. 2, n. 2, p. 79, doi. 10.1038/nchembio761
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- Article
Nanopore Sequencing Accurately Identifies the Mutagenic DNA Lesion O<sup>6</sup>‐Carboxymethyl Guanine and Reveals Its Behavior in Replication.
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- Angewandte Chemie, 2019, v. 131, n. 25, p. 8520, doi. 10.1002/ange.201902521
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PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways.
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- Cell Death & Disease, 2013, v. 4, n. 6, p. 1, doi. 10.1038/cddis.2013.133
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Effect of ethanol extract of alga Laurencia supplementation on DNA oxidation and alkylation damage in mice.
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- Asia Pacific Journal of Clinical Nutrition, 2007, v. 16, p. 164
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Requirement of the Saccharomyces cerevisiae APN1 Gene for the Repair of Mitochondrial DNA Alkylation Damage.
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- Environmental & Molecular Mutagenesis, 2009, v. 50, n. 4, p. 317, doi. 10.1002/em.20462
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The Effect of Deuterium on Induction of the ada-Regulon with Alkylating Compounds in the Cells of Escherichia coli.
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- Russian Journal of Genetics, 2018, v. 54, n. 8, p. 919, doi. 10.1134/S1022795418080124
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A systematic review on multipotent carcinogenic agent, N‐nitrosodiethylamine (NDEA), its major risk assessment, and precautions.
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- Journal of Applied Toxicology, 2024, v. 44, n. 8, p. 1108, doi. 10.1002/jat.4574
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Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1415266
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Topical Carmustine as Monotherapy or as Multimodality Therapy for Folliculotropic Mycosis Fungoides.
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- Acta Dermato-Venereologica, 2017, v. 97, n. 3, p. 373, doi. 10.2340/00015555-2551
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Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.
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- Science Signaling, 2019, v. 12, n. 568, p. N.PAG, doi. 10.1126/scisignal.aau9216
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The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
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- Genome Medicine, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13073-015-0180-0
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Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O<sup>6</sup>-methylguanine in vivo.
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- Archives of Toxicology, 2019, v. 93, n. 2, p. 559, doi. 10.1007/s00204-018-2355-0
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The Mechanism of Action of Cyclophosphamide and Its Consequences for the Development of a New Generation of Oxazaphosphorine Cytostatics.
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- Scientia Pharmaceutica, 2020, v. 88, n. 4, p. 1, doi. 10.3390/scipharm88040042
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Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas.
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- PLoS ONE, 2020, v. 15, n. 9, p. 1, doi. 10.1371/journal.pone.0238238
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Cover Feature: Understanding the Alkylation Mechanism of 3‐Chloropiperidines – NMR Kinetic Studies and Isolation of Bicyclic Aziridinium Ions (Eur. J. Org. Chem. 44/2021).
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- European Journal of Organic Chemistry, 2021, v. 2021, n. 44, p. 5896, doi. 10.1002/ejoc.202101371
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