Results
Title

Label-free immunodetection of the cancer biomarker CA125 using high-Δn liquid crystals.

Authors

Hui-Wen Su; Yun-Han Lee; Mon-Juan Lee; Yi-Chiang Hsu; Wei Lee

Abstract

A label-free and array-based optical liquid-crystal (LC) immunodetection technique for the detection of CA125 antigen, a protein biomarker most frequently used for ovarian cancer detection, was demonstrated with a nematic LC with larger birefringence (Δn) to promote sensitivity in detecting biomolecules. The LC-based immunodetection offers an alternative and sensitive approach for the detection of biomarker proteins, with the potential of replacing conventional immunoassays used in biochemical studies and clinical laboratories.

Subjects

LIQUID crystals; ANTIGENS; PATHOLOGICAL laboratories; CARCINOGENS; BIOMOLECULES

Publication

Journal of Biomedical Optics, 2014, Vol 19, Issue 7, p1

ISSN

1083-3668

Publication type

Academic Journal

DOI

10.1117/1.JBO.19.7.077006