Works matching AU Schofield, Christopher J.
Results: 225
Cover Feature: Catalysis by KDM6 Histone Demethylases – A Synergy between the Non‐Heme Iron(II) Center, Second Coordination Sphere, and Long‐Range Interactions (Chem. Eur. J. 51/2023).
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- Chemistry - A European Journal, 2023, v. 29, n. 51, p. 1, doi. 10.1002/chem.202302510
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- Article
Catalysis by KDM6 Histone Demethylases – A Synergy between the Non‐Heme Iron(II) Center, Second Coordination Sphere, and Long‐Range Interactions.
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- Chemistry - A European Journal, 2023, v. 29, n. 51, p. 1, doi. 10.1002/chem.202301305
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- Article
Dioxygen Binding Is Controlled by the Protein Environment in Non‐heme Fe<sup>II</sup> and 2‐Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene‐Forming Enzyme.
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- Chemistry - A European Journal, 2023, v. 29, n. 24, p. 1, doi. 10.1002/chem.202300138
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- Article
Front Cover: Dioxygen Binding Is Controlled by the Protein Environment in Non‐heme Fe<sup>II</sup> and 2‐Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene‐Forming Enzyme (Chem. Eur. J. 24/2023).
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- Chemistry - A European Journal, 2023, v. 29, n. 24, p. 1, doi. 10.1002/chem.202300138
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- Publication type:
- Article
Dioxygen Binding Is Controlled by the Protein Environment in Non‐heme Fe<sup>II</sup> and 2‐Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene‐Forming Enzyme.
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- Chemistry - A European Journal, 2023, v. 29, n. 24, p. 1, doi. 10.1002/chem.202300138
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- Article
Electrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer‐drug Kinetics.
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- Angewandte Chemie, 2023, v. 135, n. 42, p. 1, doi. 10.1002/ange.202309149
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- Article
In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery.
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- Angewandte Chemie, 2022, v. 134, n. 45, p. 1, doi. 10.1002/ange.202211510
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- Article
Human Oxygenase Variants Employing a Single Protein Fe<sup>II</sup> Ligand Are Catalytically Active.
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- Angewandte Chemie, 2021, v. 133, n. 26, p. 14778, doi. 10.1002/ange.202103711
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- Article
Allosteric Inhibition of the SARS‐CoV‐2 Main Protease: Insights from Mass Spectrometry Based Assays**.
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- Angewandte Chemie, 2020, v. 132, n. 52, p. 23750, doi. 10.1002/ange.202010316
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- Article
Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants.
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- Angewandte Chemie, 2019, v. 131, n. 7, p. 2012, doi. 10.1002/ange.201809424
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- Article
A human protein hydroxylase that accepts D-residues.
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- Communications Chemistry, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42004-020-0290-5
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- Article
How formaldehyde reacts with amino acids.
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- Communications Chemistry, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42004-019-0224-2
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- Article
Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases.
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- Communications Chemistry, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42004-018-0106-z
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- Article
JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships.
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- Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07183-5
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- Article
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.
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- Journal of Physiology, 2013, v. 591, n. 14, p. 3565, doi. 10.1113/jphysiol.2012.247254
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- Article
Human prolyl hydroxylase domain 2 reacts with O<sub>2</sub> and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-75761-y
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- Article
Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli.
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- Biomolecules (2218-273X), 2020, v. 10, n. 6, p. 899, doi. 10.3390/biom10060899
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- Article
Crystal structure of a clavaminate synthase–Fe(II)–2-oxoglutarate–substrate–NO complex: evidence for metal centred rearrangements
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- FEBS Letters, 2002, v. 517, n. 1-3, p. 7, doi. 10.1016/S0014-5793(02)02520-6
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- Article
Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model.
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- BMC Systems Biology, 2010, v. 4, p. 139, doi. 10.1186/1752-0509-4-139
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New developments for prevention of type 1 diabetes: a paradigm shift?
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- 2019
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- Editorial
X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.
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- Nature Structural Biology, 2001, v. 8, n. 8, p. 689, doi. 10.1038/90401
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- Article
Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.
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- Nature Structural Biology, 2000, v. 7, n. 2, p. 127
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- Article
Cover Feature: How Clavulanic Acid Inhibits Serine β‐Lactamases (ChemBioChem 22/2024).
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- ChemBioChem, 2024, v. 25, n. 22, p. 1, doi. 10.1002/cbic.202482202
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- Article
How Clavulanic Acid Inhibits Serine β‐Lactamases.
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- ChemBioChem, 2024, v. 25, n. 22, p. 1, doi. 10.1002/cbic.202400280
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- Article
Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains.
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- ChemBioChem, 2023, v. 24, n. 4, p. 1, doi. 10.1002/cbic.202200576
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- Article
Reducing Agent‐Mediated Nonenzymatic Conversion of 2‐Oxoglutarate to Succinate: Implications for Oxygenase Assays.
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- ChemBioChem, 2020, v. 21, n. 20, p. 2898, doi. 10.1002/cbic.202000185
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- Article
Quantitative MS‐Based Proteomics: Comparing the MCF‐7 Cellular Response to Hypoxia and a 2‐Oxoglutarate Analogue.
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- ChemBioChem, 2020, v. 21, n. 11, p. 1647, doi. 10.1002/cbic.201900719
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- Article
A Fluorescence‐Based Assay for Screening β‐Lactams Targeting the Mycobacterium tuberculosis Transpeptidase Ldt<sub>Mt2</sub>.
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- ChemBioChem, 2020, v. 21, n. 3, p. 368, doi. 10.1002/cbic.201900379
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- Article
Studies on the Substrate Selectivity of the Hypoxia‐Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain.
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- ChemBioChem, 2018, v. 19, n. 21, p. 2262, doi. 10.1002/cbic.201800246
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- Article
Lysine‐241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4‐Catalysed Histone Demethylation.
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- ChemBioChem, 2018, v. 19, n. 9, p. 917, doi. 10.1002/cbic.201800002
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- Article
Innenrücktitelbild: A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity (Angew. Chem. 40/2024).
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- Angewandte Chemie, 2024, v. 136, n. 40, p. 1, doi. 10.1002/ange.202414504
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- Article
A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity.
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- Angewandte Chemie, 2024, v. 136, n. 40, p. 1, doi. 10.1002/ange.202410438
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- Article
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
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- Nature, 2007, v. 448, n. 7149, p. 87, doi. 10.1038/nature05971
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- Article
Photoaffinity labelling displacement assay using multiple recombinant protein domains.
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- Biochemical Journal, 2023, v. 480, n. 15, p. 1183, doi. 10.1042/BCJ20230129
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- Article
Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells.
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- Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-0957-6
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- Article
KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.
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- Journal of Cell Biology, 2017, v. 216, n. 4, p. 999, doi. 10.1083/jcb.201607032
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- Article
Contributions of cardiac 'funny' (f) channels and sarcoplasmic reticulum Ca<sup>2+</sup> in regulating beating rate of mouse and guinea pig sinoatrial node.
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- Physiological Reports, 2015, v. 3, n. 12, p. n/a, doi. 10.14814/phy2.12561
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- Article
Author Correction: Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.
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- 2020
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- Correction Notice
Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-58482-w
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- Article
Formaldehyde quantification using ampicillin is not selective.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-54610-3
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- Article
Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-49264-0
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- Article
Combined Mass Spectrometry and Dynamic Chemistry Approach to Identify Metalloenzyme Inhibitors.
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- ChemMedChem, 2007, v. 2, n. 2, p. 175, doi. 10.1002/cmdc.200600250
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- Article
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors.
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- Angewandte Chemie International Edition, 2012, v. 51, n. 27, p. 6672, doi. 10.1002/anie.201202000
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- Article
Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications.
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- Angewandte Chemie International Edition, 2012, v. 51, n. 8, p. 1835, doi. 10.1002/anie.201106432
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- Article
Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.
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- Angewandte Chemie International Edition, 2012, v. 51, n. 7, p. 1631, doi. 10.1002/anie.201107833
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- Article
Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water.
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- Angewandte Chemie International Edition, 2009, v. 48, n. 15, p. 2796, doi. 10.1002/anie.200806296
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- Article
Evidence for a Stereoelectronic Effect in Human Oxygen Sensing.
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- Angewandte Chemie International Edition, 2009, v. 48, n. 10, p. 1784, doi. 10.1002/anie.200805427
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- Article
Thioester Hydrolysis and CC Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily.
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- Angewandte Chemie International Edition, 2008, v. 47, n. 48, p. 9322, doi. 10.1002/anie.200803906
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- Article
The catalytic domains of all human KDM5 JmjC demethylases catalyse N‐methyl arginine demethylation.
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- FEBS Letters, 2023, v. 597, n. 7, p. 933, doi. 10.1002/1873-3468.14586
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- Article
Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26.
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- FEBS Letters, 2018, v. 592, n. 19, p. 3264, doi. 10.1002/1873-3468.13231
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- Article