Synergistic effects of incorporated additives in multifunctional dressings for chronic wound healing: An updated comprehensive review.

Sadeghi‐avalshahr, Alireza; Nazarnezhad, Simin; Hassanzadeh, Halimeh; Kazemi Noughabi, Mahboubeh; Namaei‐Ghasemnia, Negar; Jalali, Mehdi

Detailed reviewing of the complicated process of wound healing reveals that it resembles an orchestrated symphony via a precise and calculated collaboration of relevant cells at the wound site. The domino‐like function of various cytokines, chemokines, growth factors and small biological molecules such as antibacterial peptides all come together to successfully execute the wound healing process. Therefore, it appears that the use of a wound dressing containing only a single additive with specific properties and capabilities may not be particularly effective in treating the complex conditions that are usual in the environment of chronic wounds. The use of multifunctional dressings incorporating various additives has shown promising results in enhancing wound healing processes. This comprehensive review article explores the synergistic effects of integrated additives in such dressings, aiming to provide an updated understanding of their combined therapeutic potential. By analysing recent advancements and research findings, this review sheds light on the intricate interactions between different additives, their mechanisms of action and their cumulative impact on wound healing outcomes. Moreover, the review discusses the importance of utilising combined therapies in wound care and highlights the potential future directions and implications for research and clinical practice in the field of wound healing management.

ANTIBIOTICS; WOUND healing; COMBINATION drug therapy; CHEMOKINES; POLYMERS; NANOSTRUCTURES; BANDAGES & bandaging; ANTIMICROBIAL peptides; WOUND infections; BIOMEDICAL materials; GROWTH factors; ANTIOXIDANTS; DRUG interactions; WOUND care; SURGICAL dressings; CYTOKINES; CHRONIC wounds & injuries; DRUG synergism; NANOPARTICLES; PHARMACODYNAMICS

Wound Repair & Regeneration, 2025, Vol 33, Issue 1, p1

1067-1927

Academic Journal

10.1111/wrr.13238