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Results: 148

Study to evaluate the optimal dose of remifentanil required to ensure apnea during magnetic resonance imaging of the heart under general anesthesia.
Published in:
Pediatric Anesthesia, 2021, v. 31, n. 5, p. 548, doi. 10.1111/pan.14164
By:
- Arnold, Philip;
- Sanaulla, Syed;
- Hampson, Lisa V.;
- Davis, Annette;
- Tan, Jacinth;
- Cowen, Ruth;
- Kaleem, Musa;
- Williams, Alexandra;
- Wadsworth, Ian;
- Jaki, Thomas;
- Anderson, Brian
Publication type:
Article
Principles of dose finding studies in cancer: a comparison of trial designs.
Published in:
Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 5, p. 1107, doi. 10.1007/s00280-012-2059-8
By:
- Jaki, Thomas;
- Clive, Sally;
- Weir, Christopher
Publication type:
Article
What is the expected benefit of patient-centric clinical development in oncology?
Published in:
Journal of Biopharmaceutical Statistics, 2022, v. 32, n. 3, p. 414, doi. 10.1080/10543406.2022.2065506
By:
- Serra, Alessandra;
- Mozgunov, Pavel;
- Jaki, Thomas;
- Rigat, Fabio
Publication type:
Article
A comparison of stochastic programming methods for portfolio level decision-making.
Published in:
Journal of Biopharmaceutical Statistics, 2020, v. 30, n. 3, p. 405, doi. 10.1080/10543406.2019.1684307
By:
- Graham, Emily;
- Jaki, Thomas;
- Harbron, Chris
Publication type:
Article
Randomized dose-escalation designs for drug combination cancer trials with immunotherapy.
Published in:
Journal of Biopharmaceutical Statistics, 2019, v. 29, n. 2, p. 359, doi. 10.1080/10543406.2018.1535503
By:
- Mozgunov, Pavel;
- Jaki, Thomas;
- Paoletti, Xavier
Publication type:
Article
Model selection based on combined penalties for biomarker identification.
Published in:
Journal of Biopharmaceutical Statistics, 2018, v. 28, n. 4, p. 735, doi. 10.1080/10543406.2017.1378662
By:
- Vradi, Eleni;
- Brannath, Werner;
- Jaki, Thomas;
- Vonk, Richardus
Publication type:
Article
Repeated measures regression mixture models.
Published in:
Behavior Research Methods, 2020, v. 52, n. 2, p. 591, doi. 10.3758/s13428-019-01257-7
By:
- Kim, Minjung;
- Van Horn, M. Lee;
- Jaki, Thomas;
- Vermunt, Jeroen;
- Feaster, Daniel;
- Lichstein, Kenneth L.;
- Taylor, Daniel J.;
- Riedel, Brant W.;
- Bush, Andrew J.
Publication type:
Article
Impact of an equality constraint on the class-specific residual variances in regression mixtures: A Monte Carlo simulation study.
Published in:
Behavior Research Methods, 2016, v. 48, n. 2, p. 813, doi. 10.3758/s13428-015-0618-8
By:
- Kim, Minjung;
- Lamont, Andrea;
- Jaki, Thomas;
- Feaster, Daniel;
- Howe, George;
- Van Horn, M.
Publication type:
Article
Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study.
Published in:
BMC Medicine, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12916-023-02937-0
By:
- Solovyeva, Olga;
- Dimairo, Munyaradzi;
- Weir, Christopher J.;
- Hee, Siew Wan;
- Espinasse, Aude;
- Ursino, Moreno;
- Patel, Dhrusti;
- Kightley, Andrew;
- Hughes, Sarah;
- Jaki, Thomas;
- Mander, Adrian;
- Evans, Thomas R. Jeffry;
- Lee, Shing;
- Hopewell, Sally;
- Rantell, Khadija Rerhou;
- Chan, An-Wen;
- Bedding, Alun;
- Stephens, Richard;
- Richards, Dawn;
- Roberts, Lesley
Publication type:
Article
Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic.
Published in:
2022
By:
- Ewings, Sean;
- Saunders, Geoff;
- Jaki, Thomas;
- Mozgunov, Pavel
Publication type:
journal article
Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity.
Published in:
Journal of Behavioral Medicine, 2022, v. 45, n. 2, p. 211, doi. 10.1007/s10865-021-00274-2
By:
- Kuhlemeier, Alena;
- Jaki, Thomas;
- Jimenez, Elizabeth Y.;
- Kong, Alberta S.;
- Gill, Hope;
- Chang, Chi;
- Resnicow, Ken;
- Wilson, Dawn K.;
- Van Horn, M. Lee
Publication type:
Article
Reducing intrusive memories after trauma via an imagery-competing task intervention in COVID-19 intensive care staff: a randomised controlled trial.
Published in:
Translational Psychiatry, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41398-023-02578-0
By:
- Iyadurai, Lalitha;
- Highfield, Julie;
- Kanstrup, Marie;
- Markham, Alfred;
- Ramineni, Varsha;
- Guo, Boliang;
- Jaki, Thomas;
- Kingslake, Jonathan;
- Goodwin, Guy M.;
- Summers, Charlotte;
- Bonsall, Michael B.;
- Holmes, Emily A.
Publication type:
Article
Recurrent events modelling of haemophilia bleeding events.
Published in:
Journal of the Royal Statistical Society: Series C (Applied Statistics), 2021, v. 70, n. 2, p. 351, doi. 10.1111/rssc.12462
By:
- Titman, Andrew C.;
- Wolfsegger, Martin J.;
- Jaki, Thomas F.
Publication type:
Article
Subgroup analysis of treatment effects for misclassified biomarkers with time‐to‐event data.
Published in:
Journal of the Royal Statistical Society: Series C (Applied Statistics), 2019, v. 68, n. 5, p. 1447, doi. 10.1111/rssc.12364
By:
- Wan, Fang;
- Titman, Andrew C.;
- Jaki, Thomas F.
Publication type:
Article
An information theoretic phase I–II design for molecularly targeted agents that does not require an assumption of monotonicity.
Published in:
Journal of the Royal Statistical Society: Series C (Applied Statistics), 2019, v. 68, n. 2, p. 347, doi. 10.1111/rssc.12293
By:
- Mozgunov, Pavel;
- Jaki, Thomas
Publication type:
Article
Exploring the issues that influence how people with rare neurological conditions engage in physical activity.
Published in:
Disability & Rehabilitation, 2024, v. 46, n. 13, p. 2789, doi. 10.1080/09638288.2023.2230128
By:
- Buscemi, Valentina;
- Boaz, Annette;
- Dawes, Helen;
- Jaki, Thomas;
- Jones, Fiona;
- Marsden, Jonathan;
- Paul, Lorna;
- Playle, Rebecca;
- Randell, Elizabeth;
- Robling, Michael;
- Rochester, Lynn;
- Busse, Monica;
- Ramdharry, Gita
Publication type:
Article
Optimal design for multi-arm multi-stage clinical trials.
Published in:
2011
By:
- Wason, James M. S.;
- Jaki, Thomas
Publication type:
Abstract
Improving safety of the continual reassessment method via a modified allocation rule.
Published in:
2019
By:
- Mozgunov, Pavel;
- Jaki, Thomas
Publication type:
journal article
An alternative method to analyse the biomarker-strategy design.
Published in:
2018
By:
- Kunz, Cornelia Ursula;
- Jaki, Thomas;
- Stallard, Nigel
Publication type:
journal article
Design and estimation in clinical trials with subpopulation selection.
Published in:
2018
By:
- Chiu, Yi‐Da;
- Koenig, Franz;
- Posch, Martin;
- Jaki, Thomas;
- Chiu, Yi-Da
Publication type:
journal article
Simultaneous confidence regions for multivariate bioequivalence.
Published in:
Statistics in Medicine, 2017, v. 36, n. 29, p. 4585, doi. 10.1002/sim.7446
By:
- Pallmann, Philip;
- Jaki, Thomas
Publication type:
Article
Comparing sampling methods for pharmacokinetic studies using model averaged derived parameters.
Published in:
2017
By:
- Barnett, Helen Yvette;
- Geys, Helena;
- Jacobs, Tom;
- Jaki, Thomas
Publication type:
journal article
Estimation in multi-arm two-stage trials with treatment selection and time-to-event endpoint.
Published in:
2017
By:
- Brückner, Matthias;
- Titman, Andrew;
- Jaki, Thomas;
- Brückner, Matthias
Publication type:
journal article
Simultaneous confidence regions for multivariate bioequivalence.
Published in:
2017
By:
- Pallmann, Philip;
- Jaki, Thomas
Publication type:
journal article
Factorial versus multi-arm multi-stage designs for clinical trials with multiple treatments.
Published in:
2017
By:
- Jaki, Thomas;
- Vasileiou, Despina
Publication type:
journal article
Asymmetric inner wedge group sequential tests with applications to verifying whether effective drug concentrations are similar in adults and children.
Published in:
2017
By:
- Hampson, Lisa V.;
- Fisch, Roland;
- Van, Linh M.;
- Jaki, Thomas
Publication type:
journal article
Designing multi-arm multi-stage clinical trials using a risk-benefit criterion for treatment selection.
Published in:
2016
By:
- Jaki, Thomas;
- Hampson, Lisa V.
Publication type:
journal article
A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data.
Published in:
Statistics in Medicine, 2015, v. 34, n. 13, p. 2138, doi. 10.1002/sim.6482
By:
- Cotterill, Amy;
- Lorand, Daniel;
- Wang, Jixian;
- Jaki, Thomas
Publication type:
Article
Authors' reply to Comments on 'Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs'.
Published in:
Statistics in Medicine, 2013, v. 32, n. 30, p. 5487, doi. 10.1002/sim.6000
By:
- Jaki, Thomas;
- Pallmann, Philip;
- Wolfsegger, Martin J.
Publication type:
Article
Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs.
Published in:
Statistics in Medicine, 2013, v. 32, n. 30, p. 5469, doi. 10.1002/sim.5886
By:
- Jaki, Thomas;
- Pallmann, Philip;
- Wolfsegger, Martin J.
Publication type:
Article
Planning multi-arm screening studies within the context of a drug development program.
Published in:
Statistics in Medicine, 2013, v. 32, n. 20, p. 3424, doi. 10.1002/sim.5787
By:
- Wason, James M. S.;
- Jaki, Thomas;
- Stallard, Nigel
Publication type:
Article
Analysing malaria drug trials on a per-individual or per-clone basis: a comparison of methods.
Published in:
2013
By:
- Jaki, Thomas;
- Parry, Alice;
- Winter, Katherine;
- Hastings, Ian
Publication type:
journal article
Analysing malaria drug trials on a per-individual or per-clone basis: a comparison of methods.
Published in:
Statistics in Medicine, 2013, v. 32, n. 17, p. 3020, doi. 10.1002/sim.5706
By:
- Jaki, Thomas;
- Parry, Alice;
- Winter, Katherine;
- Hastings, Ian
Publication type:
Article
Designing exploratory cancer trials using change in tumour size as primary endpoint.
Published in:
Statistics in Medicine, 2013, v. 32, n. 15, p. 2544, doi. 10.1002/sim.5716
By:
- Jaki, Thomas;
- André, Valérie;
- Su, Ting‐Li;
- Whitehead, John
Publication type:
Article
Optimal design of multi-arm multi-stage trials.
Published in:
Statistics in Medicine, 2012, v. 31, n. 30, p. 4269, doi. 10.1002/sim.5513
By:
- Wason, James M. S.;
- Jaki, Thomas
Publication type:
Article
A novel Phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer.
Published in:
Statistics in Medicine, 2012, v. 31, n. 18, p. 1931, doi. 10.1002/sim.5331
By:
- Whitehead, John;
- Thygesen, Helene;
- Jaki, Thomas;
- Davies, Scot;
- Halford, Sarah;
- Turner, Helen;
- Cook, Natalie;
- Jodrell, Duncan
Publication type:
Article
Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs.
Published in:
Statistics in Medicine, 2012, v. 31, n. 11/12, p. 1059, doi. 10.1002/sim.4386
By:
- Jaki, Thomas;
- Wolfsegger, Martin J.
Publication type:
Article
Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project.
Published in:
2021
By:
- Wilson, Nina;
- Biggs, Katie;
- Bowden, Sarah;
- Brown, Julia;
- Dimairo, Munyaradzi;
- Flight, Laura;
- Hall, Jamie;
- Hockaday, Anna;
- Jaki, Thomas;
- Lowe, Rachel;
- Murphy, Caroline;
- Pallmann, Philip;
- Pilling, Mark A.;
- Snowdon, Claire;
- Sydes, Matthew R.;
- Villar, Sofía S.;
- Weir, Christopher J.;
- Welburn, Jessica;
- Yap, Christina;
- Maier, Rebecca
Publication type:
journal article
Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs.
Published in:
2020
By:
- Burnett, Thomas;
- Mozgunov, Pavel;
- Pallmann, Philip;
- Villar, Sofia S.;
- Wheeler, Graham M.;
- Jaki, Thomas
Publication type:
journal article
Multi-arm multi-stage trials can improve the efficiency of finding effective treatments for stroke: a case study.
Published in:
2018
By:
- Jaki, Thomas;
- Wason, James M. S.
Publication type:
journal article
Statistical evaluation of toxicological assays: Dunnett or Williams test-take both.
Published in:
Archives of Toxicology, 2013, v. 87, n. 11, p. 1901, doi. 10.1007/s00204-013-1065-x
By:
- Jaki, Thomas;
- Hothorn, Ludwig
Publication type:
Article
Author Correction: A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.
Published in:
2020
By:
- McWilliam, Stephen J.;
- Rosala-Hallas, Anna;
- Jones, Ashley P.;
- Shaw, Victoria;
- Greenhalf, William;
- Jaki, Thomas;
- Smyth, Alan R.;
- Smyth, Rosalind L.;
- Pirmohamed, Munir
Publication type:
Correction Notice
A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-58790-1
By:
- McWilliam, Stephen J.;
- Rosala-Hallas, Anna;
- Jones, Ashley P.;
- Shaw, Victoria;
- Greenhalf, William;
- Jaki, Thomas;
- Smyth, Alan R.;
- Smyth, Rosalind L.;
- Pirmohamed, Munir
Publication type:
Article
A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-58790-1
By:
- McWilliam, Stephen J.;
- Rosala-Hallas, Anna;
- Jones, Ashley P.;
- Shaw, Victoria;
- Greenhalf, William;
- Jaki, Thomas;
- Smyth, Alan R.;
- Smyth, Rosalind L.;
- Pirmohamed, Munir
Publication type:
Article
Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation.
Published in:
2016
By:
- Wadsworth, Ian;
- Jaki, Thomas;
- Sills, Graeme;
- Appleton, Richard;
- Cross, J.;
- Marson, Anthony;
- Martland, Tim;
- McLellan, Ailsa;
- Smith, Philip;
- Pellock, John;
- Hampson, Lisa;
- Sills, Graeme J;
- Cross, J Helen;
- Marson, Anthony G;
- Smith, Philip E M;
- Pellock, John M;
- Hampson, Lisa V
Publication type:
journal article
Correction: Medicines and Healthcare products Regulatory Agency's "Consultation on proposals for legislative changes for clinical trials": a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing
Published in:
2023
By:
- Law, Martin;
- Couturier, Dominique-Laurent;
- Choodari-Oskooei, Babak;
- Crout, Phillip;
- Gamble, Carrol;
- Jacko, Peter;
- Pallmann, Philip;
- Pilling, Mark;
- Robertson, David S.;
- Robling, Michael;
- Sydes, Matthew R.;
- Villar, Sofía S.;
- Wason, James;
- Wheeler, Graham;
- Williamson, S. Faye;
- Yap, Christina;
- Jaki, Thomas
Publication type:
Correction Notice
Medicines and Healthcare products Regulatory Agency's "Consultation on proposals for legislative changes for clinical trials": a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing.
Published in:
Trials, 2023, v. 24, n. 1, p. 1, doi. 10.1186/s13063-023-07763-6
By:
- Law, Martin;
- Couturier, Dominique-Laurent;
- Choodari-Oskooei, Babak;
- Crout, Phillip;
- Gamble, Carrol;
- Jacko, Peter;
- Pallmann, Philip;
- Pilling, Mark;
- Robertson, David S.;
- Robling, Michael;
- Sydes, Matthew R.;
- Villar, Sofía S.;
- Wason, James;
- Wheeler, Graham;
- Williamson, S. Faye;
- Yap, Christina;
- Jaki, Thomas
Publication type:
Article
A seamless Phase I/II platform design with a time-to-event efficacy endpoint for potential COVID-19 therapies.
Published in:
Statistical Methods in Medical Research, 2024, v. 33, n. 11/12, p. 2115, doi. 10.1177/09622802241288348
By:
- Jaki, Thomas;
- Barnett, Helen;
- Titman, Andrew;
- Mozgunov, Pavel
Publication type:
Article
Adaptive enrichment trial designs using joint modelling of longitudinal and time-to-event data.
Published in:
Statistical Methods in Medical Research, 2024, v. 33, n. 11/12, p. 2098, doi. 10.1177/09622802241287711
By:
- Burdon, Abigail J;
- Baird, Richard D;
- Jaki, Thomas
Publication type:
Article
A comparison of model-free phase I dose escalation designs for dual-agent combination therapies.
Published in:
Statistical Methods in Medical Research, 2024, v. 33, n. 2, p. 203, doi. 10.1177/09622802231220497
By:
- Barnett, Helen;
- George, Matthew;
- Skanji, Donia;
- Saint-Hilary, Gaelle;
- Jaki, Thomas;
- Mozgunov, Pavel
Publication type:
Article