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Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation.
- Published in:
- 2016
- By:
- Publication type:
- journal article
Issues related to development of new antiseizure treatments.
- Published in:
- Epilepsia (Series 4), 2013, v. 54, p. 24, doi. 10.1111/epi.12296
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- Publication type:
- Article
Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy.
- Published in:
- Epilepsia (Series 4), 2013, v. 54, n. 6, p. 1028, doi. 10.1111/epi.12127
- By:
- Publication type:
- Article
High resolution micro-SPECT scanning in rats using <sup>125</sup>I β-CIT: Effects of chronic treatment with carbamazepine.
- Published in:
- Epilepsia (Series 4), 2009, v. 50, n. 8, p. 1962, doi. 10.1111/j.1528-1167.2009.02095.x
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- Publication type:
- Article
Multidrug-resistant genotype ( ABCB1) and seizure recurrence in newly treated epilepsy: Data from international pharmacogenetic cohorts.
- Published in:
- Epilepsia (Series 4), 2009, v. 50, n. 7, p. 1689, doi. 10.1111/j.1528-1167.2009.02059.x
- By:
- Publication type:
- Article
Drug resistance in epilepsy: Why is a simple explanation not enough?
- Published in:
- 2007
- By:
- Publication type:
- Letter
Pharmacokinetics and Drug Interactions with Zonisamide.
- Published in:
- Epilepsia (Series 4), 2007, v. 48, n. 3, p. 435, doi. 10.1111/j.1528-1167.2007.00983.x
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- Publication type:
- Article
Response: Lack of Association between the C3435T Polymorphism in the Human Multidrug Resistance ( MDR1) Gene and Response to Antiepileptic Drug Treatment.
- Published in:
- 2006
- By:
- Publication type:
- Letter
Lack of Association between the C3435T Polymorphism in the Human Multidrug Resistance (MDR1) Gene and Response to Antiepileptic Drug Treatment.
- Published in:
- Epilepsia (Series 4), 2005, v. 46, n. 5, p. 643, doi. 10.1111/j.1528-1167.2005.46304.x
- By:
- Publication type:
- Article
Vigabatrin, but not Gabapentin or Topiramate, Produces Concentration-related Effects on Enzymes and Intermediates of the GABA Shunt in Rat Brain and Retina.
- Published in:
- Epilepsia (Series 4), 2003, v. 44, n. 7, p. 886, doi. 10.1046/j.1528-1157.2003.04203.x
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- Publication type:
- Article
Regional Expression of Multidrug Resistance Genes in Genetically Epilepsy-prone Rat Brain after a Single Audiogenic Seizure.
- Published in:
- Epilepsia (Series 4), 2002, v. 43, n. 11, p. 1318, doi. 10.1046/j.1528-1157.2002.156702.x
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- Publication type:
- Article
Topiramate in Patients with Learning Disability and Refractory Epilepsy.
- Published in:
- Epilepsia (Series 4), 2002, v. 43, n. 4, p. 399, doi. 10.1046/j.1528-1157.2002.47401.x
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- Publication type:
- Article
Effects of anti-epileptic drugs on glutamine synthetase activity in mouse brain.
- Published in:
- British Journal of Pharmacology, 1999, v. 126, n. 7, p. 1634, doi. 10.1038/sj.bjp.0702472
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- Publication type:
- Article
Pharmacological diversity amongst approved and emerging antiseizure medications for the treatment of developmental and epileptic encephalopathies.
- Published in:
- Therapeutic Advances in Neurological Disorders, 2023, p. 1, doi. 10.1177/17562864231191000
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- Publication type:
- Article
Pharmacological diversity amongst approved and emerging antiseizure medications for the treatment of developmental and epileptic encephalopathies.
- Published in:
- Therapeutic Advances in Neurological Disorders, 2023, v. 16, p. 1, doi. 10.1177/17562864231191000
- By:
- Publication type:
- Article
Role of Common Genetic Variants for Drug-Resistance to Specific Anti-Seizure Medications.
- Published in:
- Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.688386
- By:
- Publication type:
- Article
A quantitative framework to inform extrapolation decisions in children.
- Published in:
- Journal of the Royal Statistical Society: Series A (Statistics in Society), 2020, v. 183, n. 2, p. 515, doi. 10.1111/rssa.12532
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- Publication type:
- Article
The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles.
- Published in:
- Frontiers in Neurology, 2021, v. 12, p. 1, doi. 10.3389/fneur.2021.625017
- By:
- Publication type:
- Article
Advantages of Repeated Low Dose against Single High Dose of Kainate in C57BL/6J Mouse Model of Status Epilepticus: Behavioral and Electroencephalographic Studies.
- Published in:
- PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0096622
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- Publication type:
- Article
The impact of postsynaptic density 95 blocking peptide (Tat‐NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate‐induced epileptogenesis.
- Published in:
- Journal of Neuroscience Research, 2019, v. 97, n. 11, p. 1378, doi. 10.1002/jnr.24441
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- Publication type:
- Article
Genomic and clinical predictors of lacosamide response in refractory epilepsies.
- Published in:
- Epilepsia Open, 2019, v. 4, n. 4, p. 563, doi. 10.1002/epi4.12360
- By:
- Publication type:
- Article
A genome‐wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.
- Published in:
- Epilepsia Open, 2019, v. 4, n. 1, p. 102, doi. 10.1002/epi4.12297
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- Publication type:
- Article
Antiepileptic Drug Transport—Of Mice and Men.
- Published in:
- Epilepsy Currents, 2008, v. 8, n. 2, p. 48, doi. 10.1111/j.1535-7511.2008.00234.x
- By:
- Publication type:
- Article
Seizures Beget Seizures: A Lack of Experimental Evidence and Clinical Relevance Fails to Dampen Enthusiasm.
- Published in:
- Epilepsy Currents, 2007, v. 7, n. 4, p. 103, doi. 10.1111/j.1535-7511.2007.00189.x
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- Publication type:
- Article
Means, Motive, and Opportunity: Establishing Culpability in Pharmacoresistant Epilepsy.
- Published in:
- Epilepsy Currents, 2007, v. 7, n. 2, p. 51, doi. 10.1111/j.1535-7511.2007.00166.x
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- Publication type:
- Article
The Multidrug Transporter Hypothesis of Refractory Epilepsy: Corroboration and Contradiction in Equal Measure.
- Published in:
- Epilepsy Currents, 2006, v. 6, n. 2, p. 51, doi. 10.1111/j.1535-7511.2006.00092.x
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- Publication type:
- Article
Excitable but Lacking in Energy: Contradictions in the Human Epileptic Hippocampus.
- Published in:
- Epilepsy Currents, 2006, v. 6, n. 1, p. 6, doi. 10.1111/j.1535-7511.2005.00078.x
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- Publication type:
- Article
Pharmacogenetics of Epilepsy: One Step Forward?
- Published in:
- Epilepsy Currents, 2005, v. 5, n. 6, p. 236, doi. 10.1111/j.1535-7511.2005.00074.x
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- Publication type:
- Article
Not Another Gabapentin Mechanism!
- Published in:
- Epilepsy Currents, 2005, v. 5, n. 2, p. 75, doi. 10.1111/j.1535-7597.2005.05210.x
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- Publication type:
- Article
Current Literature Changing Channels: Mechanisms and Responsiveness to Antiepileptic Drugs in Chronic Epilepsy.
- Published in:
- Epilepsy Currents, 2004, v. 4, n. 3, p. 98, doi. 10.1111/j.1535-7597.2004.43005.x
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- Publication type:
- Article
Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs.
- Published in:
- Health Technology Assessment, 2021, v. 25, n. 75, p. vii, doi. 10.3310/hta25750
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- Publication type:
- Article
A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam.
- Published in:
- Epilepsia (Series 4), 2022, v. 63, n. 6, p. 1563, doi. 10.1111/epi.17228
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- Publication type:
- Article
High‐mobility group box 1 as a predictive biomarker for drug‐resistant epilepsy: A proof‐of‐concept study.
- Published in:
- Epilepsia (Series 4), 2022, v. 63, n. 1, p. e1, doi. 10.1111/epi.17116
- By:
- Publication type:
- Article
The ups and downs of alkyl‐carbamates in epilepsy therapy: How does cenobamate differ?
- Published in:
- Epilepsia (Series 4), 2021, v. 62, n. 3, p. 596, doi. 10.1111/epi.16832
- By:
- Publication type:
- Article
A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ‐aminobutyric acidergic anticonvulsant.
- Published in:
- Epilepsia (Series 4), 2020, v. 61, n. 10, p. 2106, doi. 10.1111/epi.16644
- By:
- Publication type:
- Article
Functional analysis of epilepsy‐associated variants in STXBP1/Munc18‐1 using humanized Caenorhabditis elegans.
- Published in:
- Epilepsia (Series 4), 2020, v. 61, n. 4, p. 810, doi. 10.1111/epi.16464
- By:
- Publication type:
- Article
Prospective clinical trials to investigate clinical and molecular biomarkers.
- Published in:
- Epilepsia (Series 4), 2017, v. 58, p. 20, doi. 10.1111/epi.13782
- By:
- Publication type:
- Article
An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters.
- Published in:
- Epilepsia (Series 4), 2016, v. 57, n. 9, p. 1467, doi. 10.1111/epi.13473
- By:
- Publication type:
- Article
Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.
- Published in:
- 2019
- By:
- Publication type:
- journal article
Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.
- Published in:
- 2017
- By:
- Publication type:
- journal article
Assessing the role of rare genetic variants in drug‐resistant, non‐lesional focal epilepsy.
- Published in:
- Annals of Clinical & Translational Neurology, 2021, v. 8, n. 7, p. 1376, doi. 10.1002/acn3.51374
- By:
- Publication type:
- Article
Genetic predictors of lamotrigine maintenance dose; a role for P-glycoprotein?
- Published in:
- 2010
- By:
- Publication type:
- Abstract
Testing for pharmacogenomic predictors of ppRNFL thinning in individuals exposed to vigabatrin.
- Published in:
- Frontiers in Neuroscience, 2023, p. 01, doi. 10.3389/fnins.2023.1156362
- By:
- Publication type:
- Article
Genetic regulation of gene expression in the epileptic human hippocampus.
- Published in:
- Human Molecular Genetics, 2017, v. 26, n. 9, p. 1759, doi. 10.1093/hmg/ddx061
- By:
- Publication type:
- Article
Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality.
- Published in:
- Human Molecular Genetics, 2015, v. 24, n. 15, p. 4306, doi. 10.1093/hmg/ddv163
- By:
- Publication type:
- Article
N <sup>w</sup>-Propyl- l-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.
- Published in:
- European Journal of Neuroscience, 2012, v. 36, n. 9, p. 3194, doi. 10.1111/j.1460-9568.2012.08234.x
- By:
- Publication type:
- Article
Inflammation and Epilepsy: The Foundations for a New Therapeutic Approach in Epilepsy?
- Published in:
- Epilepsy Currents, 2012, v. 12, n. 1, p. 8, doi. 10.5698/1535-7511-12.1.8
- By:
- Publication type:
- Article
Breaching the Barrier and Inflaming Epilepsy Research.
- Published in:
- Epilepsy Currents, 2009, v. 9, n. 5, p. 148, doi. 10.1111/j.1535-7511.2009.01324.x
- By:
- Publication type:
- Article
Novel Therapeutic Strategies for Epilepsy—Releasing the Gene Genie.
- Published in:
- Epilepsy Currents, 2009, v. 9, n. 1, p. 26, doi. 10.1111/j.1535-7511.2008.01280.x
- By:
- Publication type:
- Article