Expanded criteria for retinopathy of prematurity screening in moderately preterm infants: Single-center pilot study.

Yum, Sook Kyung; Moon, Cheong‐Jun; Youn, Young‐Ah; Lee, Jung Hyun; Kim, So Young; Sung, In Kyung

Background While developed countries seek to lower the gestational age and birthweight parameters in retinopathy of prematurity (ROP) screening, older, larger infants still develop ROP in other parts of the world. The aim of this study was therefore to define criteria to identify potential ROP developers who are outliers of the common screening range. Methods A retrospective medical record review was performed in 147 inborn moderately preterm infants admitted to the neonatal intensive care unit during the study period. Univariate and logistic regression analysis was carried out. Results Forty-two infants developed ROP. Gestational age (31.4 ± 1.1 vs 32.4 ± 1.0 weeks, P = 0.000) and birthweight (1607.7 ± 339.4 vs 1846.4 ± 317.2 g, P = 0.000) were lower in those who developed ROP. Respiratory distress syndrome ( P = 0.026) and documented sepsis ( P = 0.003) were significant comorbidities on univariate analysis. Inotrope need >72 h starting in the first week of life ( P = 0.004; OR, 5.181) and more than three transfusions of packed red blood cells ( P = 0.028; OR, 3.891) were also significant, both on univariate and multivariate analysis. Conclusions In moderately preterm infants, status should be evaluated in order to effectively select candidates for ROP screening without missing potential ROP developers.

RESPIRATORY distress syndrome; BIRTH weight; RETROLENTAL fibroplasia; BLOOD transfusion; CARDIOTONIC agents; DEVELOPING countries; FISHER exact test; GESTATIONAL age; PREMATURE infants; MEDICAL screening; NEONATAL intensive care; PEDIATRICS; LOGISTIC regression analysis; DEVELOPED countries; PILOT projects; NEONATAL intensive care units; RETROSPECTIVE studies; DATA analysis software; DIAGNOSIS; THERAPEUTICS

Pediatrics International, 2016, Vol 58, Issue 11, p1158

1328-8067

Academic Journal

10.1111/ped.12996