Works matching DE "DRUG target"

Results: 5000

Molecular docking of quercetin: a promising approach for the development of new anti-inflammatory and analgesic drugs.

Published in:

Natural Product Research, 2025, v. 39, n. 11, p. 3202, doi. 10.1080/14786419.2024.2333053

By:

Ettitaou, Amina;
Kabdy, Hamid;
Oubella, Khadija;
Raoui, Karima;
Oubahmane, Mehdi;
Aboufatima, Rachida;
Elyazouli, Loubna;
Garzoli, Stefania;
Chait, Abderrahman

Publication type:

Article

Radiotheranostic landscape: A review of clinical and preclinical development.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2025, v. 52, n. 7, p. 2685, doi. 10.1007/s00259-025-07103-7

By:

Tran, Ha H.;
Yamaguchi, Aiko;
Manning, H. Charles

Publication type:

Article

The Alkaloid Gelsemine Reduces Aβ Peptide Toxicity by Targeting Transglutaminase Type 2 Enzyme.

Published in:

Plants (2223-7747), 2025, v. 14, n. 10, p. 1556, doi. 10.3390/plants14101556

By:

Panes-Fernández, Jessica;
Marileo, Ana M.;
Espinoza-Rubilar, Nicole;
Meza, Macarena E.;
Salgado-Martínez, Bernardita A.;
Gaete-Riquelme, Krishna;
Moraga-Cid, Gustavo;
Castro, Patricio A.;
Burgos, Carlos F.;
Fuentealba, Jorge;
Yévenes, Gonzalo E.

Publication type:

Article

Genome-Wide Analysis of Zm4CL Genes Identifies Zm4CL8 Regulating Drought and Salt Tolerance in Maize.

Published in:

Agronomy, 2025, v. 15, n. 5, p. 1100, doi. 10.3390/agronomy15051100

By:

Zhang, Ze;
Wang, Yanbin;
Li, Rong

Publication type:

Article

Shed Syndecan-4 and Its Possible Roles in Osteoarthritis.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1037, doi. 10.3390/biomedicines13051037

By:

He, Kangping;
Ren, Haozhe;
Chen, Xiaohua;
He, Feng;
Zhang, Yueying;
Zhang, Hongyun;
Li, Feifei;
Yu, Shibin

Publication type:

Article

Transcriptomic Profiling Uncovers Molecular Basis for Sugar and Acid Metabolism in Two Pomegranate (Punica granatum) Varieties.

Published in:

Foods, 2025, v. 14, n. 10, p. 1755, doi. 10.3390/foods14101755

By:

Ke, Ding;
Zhang, Yilong;
Teng, Yingfen;
Zhao, Xueqing

Publication type:

Article

Integrating Transcriptomic and Proteomic Data: IL‐27B as a Key Protein in the Development of Septic Cardiomyopathy—A Retrospective Study.

Published in:

Immunity, Inflammation & Disease, 2025, v. 13, n. 5, p. 1, doi. 10.1002/iid3.70207

By:

Mao, Yifeng;
Chen, Qingqing;
Jiang, Yongpo;
Zhang, Xijiang;
Si, Qin;
Xu, Panpan;
Zhang, Zhongheng;
Zheng, Cheng;
Lin, Ronghai

Publication type:

Article

Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2–Related Factor 2 Function in Leukemia and Other Cancers.

Published in:

Cells (2073-4409), 2025, v. 14, n. 10, p. 713, doi. 10.3390/cells14100713

By:

Hasan, Syed K.;
Jayakumar, Sundarraj;
Espina Barroso, Eliezer;
Jha, Anup;
Catalano, Gianfranco;
Sandur, Santosh K.;
Noguera, Nelida I.

Publication type:

Article

Nicotinamide N-Methyltransferase (NNMT) and Liver Cancer: From Metabolic Networks to Therapeutic Targets.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 719, doi. 10.3390/biom15050719

By:

Lai, Shi-Yan;
Zhu, Xiao-Juan;
Sun, Wei-Dong;
Bi, Shuang-Zhou;
Zhang, Chen-Ying;
Liu, An;
Li, Jiang-Hua

Publication type:

Article

Post-Translational Modifications in Multiple Myeloma: Mechanisms of Drug Resistance and Therapeutic Opportunities.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 702, doi. 10.3390/biom15050702

By:

Hu, Shuoyang;
Xu, Jirun;
Cui, Weiyan;
Jin, Haoran;
Wang, Xiaoyu;
Maimaitiyiming, Yasen

Publication type:

Article

Celebrating Ulrik Ringborg: Multi-Omics-Based Patient Stratification for Precision Cancer Treatment.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 693, doi. 10.3390/biom15050693

By:

Teleanu, Maria-Veronica;
Schneider, Annika;
Ball, Claudia R.;
Leber, Mathias Felix;
Stange, Christoph;
Krieghoff-Henning, Eva;
Beck, Katja;
Heilig, Christoph E.;
Kreutzfeldt, Simon;
Kuster, Bernhard;
Lipka, Daniel B.;
Fröhling, Stefan

Publication type:

Article

Bolstering CD8 + T Cells' Antitumor Immunity: A Promising Strategy to Improve the Response to Advanced Prostate Cancer Treatment.

Published in:

Biology (2079-7737), 2025, v. 14, n. 5, p. 544, doi. 10.3390/biology14050544

By:

Dang, Beijing;
Liang, Lixin;
Li, Zhijun;
Luo, Junli;
Zhong, Shangwei

Publication type:

Article

Comparative Analysis of Cytokine Expression Profiles in Prostate Cancer Patients.

Published in:

Biology (2079-7737), 2025, v. 14, n. 5, p. 505, doi. 10.3390/biology14050505

By:

Coelho, Karoline Brito Caetano Andrade;
Wosniaki, Denise Kusma;
Pereira, Jonatas Luiz;
Luz, Murilo;
Albrecht, Letusa;
Nardin, Jeanine Marie;
Aoki, Mateus Nobrega;
Reis, Leonardo O.;
dos Reis, Rodolfo Borges;
Zanette, Dalila Lucíola

Publication type:

Article

A Computational Approach to Identify Novel Protein Targets Uncovers New Potential Mechanisms of Action of Mirtazapine S(+) and R(−) Enantiomers in Rett Syndrome.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70093

By:

Roggero, Ottavia Maria;
Gualandi, Nicolò;
Ciraci, Viviana;
Berutto, Vittoria;
Carosati, Emanuele;
Tongiorgi, Enrico

Publication type:

Article

Astrocyte Dysfunctions in Obsessive Compulsive Disorder: Rethinking Neurobiology and Therapeutic Targets.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70092

By:

Gonzalez, Laurine;
Bezzi, Paola

Publication type:

Article

PKG‐Mediated Phosphorylation of TOP2A Activates HDAC to Drive Photoreceptor Cell Death in rd1 Mouse Inherited Retinal Degeneration.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70077

By:

Dong, Yujie;
Zuo, Wandong;
Li, Yan;
Feng, Xiaoxiao;
Guo, Chunming;
Chen, Maorong;
Yan, Jie;
Hou, Chunjiang;
Peng, Hua;
Hu, Zhulin;
Liu, Hai;
Paquet‐Durand, François;
Jiao, Kangwei

Publication type:

Article

Thyroid-Stimulating Hormone: An Important Target for the Prevention of Nonalcoholic Fatty Liver Disease.

Published in:

Physiological Research, 2025, v. 74, n. 2, p. 175, doi. 10.33549/physiolres.935453

By:

Zixuan WANG;
Hanyu WANG;
Hui SUN

Publication type:

Article

The impact of gliomas on the normal brain microenvironment: a pilot study.

Published in:

Journal of Histotechnology, 2025, v. 48, n. 2, p. 93, doi. 10.1080/01478885.2024.2408505

By:

Riha, Nicole;
Moore, Jacen S.;
Criswell, Sheila

Publication type:

Article

Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02543-4

By:

Kong, Xiuwen;
Wang, Xinda;
Xia, Qiushi;
Hu, Qingqing;
Yu, Wenqian;
Huang, Qiuru;
Li, Jiaxin;
Wang, Chenyu;
Lin, Ziwen;
Liu, Yiheng;
Qi, Yujuan;
Tan, Xiaofang;
Zheng, Bo;
Yu, Jun

Publication type:

Article

Super Responders in Moderate-to-Severe Atopic Dermatitis Under Treatment with Dupilumab: An Explorative Real-World Study.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 10, p. 3480, doi. 10.3390/jcm14103480

By:

Mastorino, Luca;
Mendes-Bastos, Pedro;
Cavaliere, Giovanni;
Siliquini, Niccolo;
Ortoncelli, Michela;
Quaglino, Pietro;
Ribero, Simone

Publication type:

Article

蛋白磷酸酶 2A 与肿瘤发生发展关系的研究进展.

Published in:

Journal of Jilin University (Medicine Edition), 2025, v. 51, n. 2, p. 534, doi. 10.13481/j.1671⁃587X.20250229

By:

张慧灵;
郭文秀;
孟峻

Publication type:

Article

Crystal structures of the putative endoribonuclease L‐PSP from Entamoeba histolytica.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2025, v. 81, n. 6, p. 226, doi. 10.1107/S2053230X25003875

By:

Ojuromi, Oladele T.;
Giwa, Abdulazeez O.;
Gardberg, Anna;
Subramanian, Sandhya;
Myler, Peter J.;
Abendroth, Jan;
Staker, Bart;
Asojo, Oluwatoyin A.

Publication type:

Article

Repositioning FDA-Approved Sulfonamide-Based Drugs as Potential Carbonic Anhydrase Inhibitors in Trypanosoma cruzi : Virtual Screening and In Vitro Studies.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 669, doi. 10.3390/ph18050669

By:

Ortiz-Pérez, Eyra;
Moreno-Rodríguez, Adriana;
Delgado-Maldonado, Timoteo;
Ortega-Balleza, Jessica L.;
González-González, Alonzo;
Paz-González, Alma D.;
Vázquez, Karina;
Avalos-Navarro, Guadalupe;
Giovannuzzi, Simone;
Supuran, Claudiu T.;
Rivera, Gildardo

Publication type:

Article

The Cordyceps Genus as a Potential Source of Bioactive Compounds for Adjuvant Cancer Therapy: A Network Pharmacology Approach.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 667, doi. 10.3390/ph18050667

By:

Gonzalez-Llerena, Jose Luis;
Treviño-Almaguer, Daniela;
Leal-Mendez, Jesus Alejandro;
Garcia-Valdez, Gael;
Balderas-Moreno, Arely Guadalupe;
Heya, Michel Stéphane;
Balderas-Renteria, Isaias;
Camacho-Corona, María del Rayo;
Espinosa-Rodriguez, Bryan Alejandro

Publication type:

Article

Exploring Therapeutic Potential of Bi-Qi Capsules in Treatment of Gout by Discovering Crucial Drug Targets.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 618, doi. 10.3390/ph18050618

By:

Xie, Jing;
Zhang, Yu;
Ren, Rong;
Bu, Ruizhen;
Chen, Liying;
Hou, Juezhuo;
Shang, Dandan;
Liu, Yadong;
Wang, Dan;
Wang, Tao;
Zhou, Hong

Publication type:

Article

A Highly Sensitive Giant Magnetoresistive (GMR) Biosensor Based on the Magnetic Flux Concentrator Effect.

Published in:

Micromachines, 2025, v. 16, n. 5, p. 559, doi. 10.3390/mi16050559

By:

Sun, Hao;
Li, Jiao;
Zhao, Changhui;
Ren, Chunming;
Tian, Tian;
Lei, Chong;
Sun, Xuecheng

Publication type:

Article

Dysregulation of Locus-Specific Repetitive Elements in TCGA Pan-Cancers.

Published in:

Genes, 2025, v. 16, n. 5, p. 528, doi. 10.3390/genes16050528

By:

Wang, Chao;
Liang, Chun

Publication type:

Article

Identification of the immune-associated enhancer RNA SATB1-AS1 as a novel biomarker for thymic cancer prognosis.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0319965

By:

Wang, Hongpeng;
Huang, Yichu;
Min, Guangtao;
Jiang, Lei

Publication type:

Article

Therapeutic role of Crateva religiosa in diabetic nephropathy: Insights into key signaling pathways.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0324028

By:

Ali, Muhammad;
Irfan, Hafiz M.;
Alamgeer;
Ullah, Aman;
Abdellattif, Magda H.;
Elodemi, Mahmoud;
Zubair, Mohammad;
Khan, Ajmal;
Al-Harrasi, Ahmed

Publication type:

Article

Precision Medicine for Pediatric Glioma and NF1-Associated Tumors: The Role of Small Molecule Inhibitors.

Published in:

Current Oncology, 2025, v. 32, n. 5, p. 280, doi. 10.3390/curroncol32050280

By:

Renzi, Samuele;
Bennett, Julie;
Thacker, Nirav;
Cacciotti, Chantel

Publication type:

Article

Therapeutic and Prognostic Potential of G Protein‐Coupled Receptors in Lung Adenocarcinoma: Evidence From Transcriptome Data and In Vitro Experiments.

Published in:

Clinical Respiratory Journal, 2025, v. 19, n. 5, p. 1, doi. 10.1111/crj.70080

By:

Yang, Feiyan;
Yang, Jianye;
Yang, Guobiao;
Zhang, Ya

Publication type:

Article

Mitochondrial Calcium Uniporter (MCU)-Mediated Calcium Overload in Psychoactive Drug Neurotoxicity: From Pathogenesis to Therapeutic Targets.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4732, doi. 10.3390/ijms26104732

By:

Yang, Xinyan;
Chen, Yinyu;
Zheng, Gaolin;
Nie, Qianyun;
Zhang, Peng

Publication type:

Article

AI-Driven Drug Target Screening Platform Identified Oncogene CACNA2D1 Activated by Enhancer Infestation in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4697, doi. 10.3390/ijms26104697

By:

Chung, Dittman Lai-Shun;
Leung, Geoffrey Ho Duen;
Liu, Songran;
Lok, Sarah Wing Yan;
Xin, Ying;
Xia, Yunfei;
Zhavoronkov, Alex;
Pun, Frank W.;
Ng, Wai-Tong;
Dai, Wei

Publication type:

Article

In Silico Approach to Design of New Multi-Targeted Inhibitors Based on Quinoline Ring with Potential Anticancer Properties.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4620, doi. 10.3390/ijms26104620

By:

Czyżnikowska, Żaneta;
Mysłek, Martyna;
Marciniak, Aleksandra;
Płaczek, Remigiusz;
Kotynia, Aleksandra;
Krzyżak, Edward

Publication type:

Article

Therapeutic Applications of Poly-miRNAs and miRNA Sponges.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4535, doi. 10.3390/ijms26104535

By:

Avendaño-Portugal, Cynthia;
Montaño-Samaniego, Mariela;
Guttman-Bazbaz, Raquel;
Bravo-Estupiñan, Diana M.;
Ibáñez-Hernández, Miguel

Publication type:

Article

Peroxisome Proliferator-Activated Receptors (PPARs) May Mediate the Neuroactive Effects of Probiotic Metabolites: An In Silico Approach.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4507, doi. 10.3390/ijms26104507

By:

Parra, Irving;
Carrasco-Carballo, Alan;
Palafox-Sanchez, Victoria;
Martínez-García, Isabel;
Aguilera, José;
Góngora-Alfaro, José L.;
Aranda-González, Irma Isela;
Tizabi, Yousef;
Mendieta, Liliana

Publication type:

Article

Metabolic Pathways and Molecular Regulatory Mechanisms of Fruit Color Change During Greening Stage of Peppers (Capsicum annuum L.).

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4508, doi. 10.3390/ijms26104508

By:

Wei, Mengyuan;
Wen, Junqin;
Ren, Yanjing;
Shao, Dengkui;
Wang, Yayi;
Li, Jiang;
Li, Quanhui

Publication type:

Article

Identification Of Mir-103a/PLEKHA1 Pair As Candidate Biomarkers And Therapeutic Targets For Skin Aging By Bioinformatics Analysis.

Published in:

Frontiers in Health Informatics, 2025, v. 14, n. 2, p. 2245

By:

Clarina, Silvia;
Siswanto, Ferbian Milas;
Pranandi, Ian;
Novi Handayani, Maria Dara;
Dewi, Rita;
Regina

Publication type:

Article

Eosinophils in chronic obstructive pulmonary disease.

Published in:

Therapeutic Advances in Respiratory Disease, 2025, p. 1, doi. 10.1177/17534666251335800

By:

Vanetti, Marco;
Visca, Dina;
Ardesi, Francesco;
Zappa, Martina;
Pignatti, Patrizia;
Spanevello, Antonio

Publication type:

Article

miR-124, miR-126-3p, and miR-200b: Potential therapeutic targets for VEGF-mediated complications in proliferative diabetic retinopathy.

Published in:

Indian Journal of Ophthalmology, 2025, v. 73, n. 6, p. 886, doi. 10.4103/IJO.IJO_1791_24

By:

Akaray, Irfan;
Ozal, Sadık Altan;
Sancar, Hilal;
Ozal, Ece;
Ayaz, Lokman

Publication type:

Article

Research progress on the development and progression of long non-coding RNA in upper gastrointestinal adenocarcinoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02800-z

By:

Wei, Haitao;
Lin, Xiaojin;
Fang, Ruirui;
Zhang, Sa;
Li, Li

Publication type:

Article

Fumarate hydratase in cancer research: scientific trends and findings over 22 years.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02312-w

By:

Yalaza, Cem;
Antmen, Serife Efsun

Publication type:

Article

In Silico Identification of LSD1 Inhibition-Responsive Targets in Small Cell Lung Cancer.

Published in:

Bioengineering (Basel), 2025, v. 12, n. 5, p. 504, doi. 10.3390/bioengineering12050504

By:

Nalkiran, Ihsan;
Sevim Nalkiran, Hatice;
Ozcelik, Neslihan;
Kivrak, Mehmet

Publication type:

Article

Neurological Mechanisms Exploration and Therapeutic Targets in Segmental Vitiligo Accompanied by White Hair.

Published in:

Pigment Cell & Melanoma Research, 2025, v. 38, n. 3, p. 1, doi. 10.1111/pcmr.70020

By:

Fu, Shiqi;
Xie, Bo;
Song, Xiuzu

Publication type:

Article

Systems virology: host-directed approaches to viral pathogenesis and drug targeting.

Published in:

Nature Reviews Microbiology, 2013, v. 11, n. 7, p. 455, doi. 10.1038/nrmicro3036

By:

Law, G. Lynn;
Korth, Marcus J.;
Benecke, Arndt G.;
Katze, Michael G.

Publication type:

Article

Parasitology: Hidden treasure uncovered?

Published in:

Nature Reviews Microbiology, 2008, v. 6, n. 8, p. 570, doi. 10.1038/nrmicro1959

By:

van Ooij, Christiaan

Publication type:

Article

Preliminary Study of hsa-mir-626 Change in the Cerebrospinal Fluid in Parkinson's Disease.

Published in:

2021

By:

Qin, Li-Xia;
Tan, Jie-Qiong;
Zhang, Hai-Nan;
Tang, Jian-Guang;
Jiang, Bo;
Shen, Xiang-Min;
Guo, Ji-Feng;
Tan, Li-Ming;
Tang, Beisha;
Wang, Chun-Yu

Publication type:

journal article

Meta-analysis of endometrial transcriptome data reveals novel molecular targets for recurrent implantation failure.

Published in:

Journal of Assisted Reproduction & Genetics, 2024, v. 41, n. 5, p. 1417, doi. 10.1007/s10815-024-03077-x

By:

Chettiar, Venkatlaxmi;
Patel, Alpesh;
Chettiar, Shiva Shankaran;
Jhala, Devendrasinh D.

Publication type:

Article

Identification of potential diagnostic biomarkers and therapeutic targets for endometriosis based on bioinformatics and machine learning analysis.

Published in:

Journal of Assisted Reproduction & Genetics, 2023, v. 40, n. 10, p. 2439, doi. 10.1007/s10815-023-02903-y

By:

Hosseini, Maryam;
Hammami, Behnaz;
Kazemi, Mohammad

Publication type:

Article

Comparison of miRNA landscapes between the human oocytes with or without arrested development.

Published in:

Journal of Assisted Reproduction & Genetics, 2022, v. 39, n. 10, p. 2227, doi. 10.1007/s10815-022-02614-w

By:

Wei, Lina;
Yang, Xi;
Gao, Linzhi;
Liang, Zhongkun;
Yu, Hao;
Zhang, Ningfeng;
Li, Yi

Publication type:

Article