Post‐extrapontine myelinolysis mimicking multiple system atrophy.

Inamori, Yukiko; Matsuyoshi, Ayano; Nakazawa, Yusuke; Shiraishi, Wataru

A 59-year-old Japanese woman presented with symptoms resembling multiple system atrophy, including parkinsonism, after receiving concentrated sodium infusion therapy for hyponatremia during breast cancer treatment 20 years prior. Despite initial suspicions of multiple system atrophy, further examination revealed extrapontine myelinolysis (EPM) as the cause of her symptoms, with bilateral putamen atrophy resembling the former condition. This case highlights the importance of considering EPM in patients with parkinsonism and a history of osmotic demyelination syndromes, even in the absence of brainstem lesions.

SINGLE-photon emission computed tomography; MULTIPLE system atrophy; MAGNETIC resonance imaging; INFUSION therapy; JAPANESE women

Neurology & Clinical Neuroscience, 2025, Vol 13, Issue 1, p86

2049-4173

Academic Journal

10.1111/ncn3.12845