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Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier.
Published in:
PLoS Biology, 2020, v. 18, n. 12, p. 1, doi. 10.1371/journal.pbio.3001008
By:
- Gallego-Delgado, Patricia;
- James, Rachel;
- Browne, Eleanor;
- Meng, Joanna;
- Umashankar, Swetha;
- Tan, Li;
- Picon, Carmen;
- Mazarakis, Nicholas D.;
- Faisal, A. Aldo;
- Howell, Owain W.;
- Reynolds, Richard
Publication type:
Article
Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.
Published in:
Frontiers in Cellular Neuroscience, 2023, v. 17, p. 1, doi. 10.3389/fncel.2023.1094106
By:
- Evans, Rhian;
- Watkins, Lewis M.;
- Hawkins, Kristen;
- Santiago, Gabriella;
- Demetriou, Constantinos;
- Naughton, Michelle;
- Dittmer, Marie;
- Rees, Mark I.;
- Fitzgerald, Denise;
- Morgan, B. Paul;
- Neal, James W.;
- Howell, Owain W.
Publication type:
Article
A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis.
Published in:
Annals of Neurology, 2010, v. 68, n. 4, p. 477, doi. 10.1002/ana.22230
By:
- Magliozzi, Roberta;
- Howell, Owain W.;
- Reeves, Cheryl;
- Roncaroli, Federico;
- Nicholas, Richard;
- Serafini, Barbara;
- Aloisi, Francesca;
- Reynolds, Richard
Publication type:
Article
Two binding sites for [<sup>3</sup>H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2010, v. 30, n. 9, p. 1608, doi. 10.1038/jcbfm.2010.63
By:
- Owen, David R.;
- Howell, Owain W.;
- Tang, Sac-Pham;
- Wells, Lisa A.;
- Bennacef, Idriss;
- Bergstrom, Mats;
- Gunn, Roger N.;
- Rabiner, Eugenii A.;
- Wilkins, Martin R.;
- Reynolds, Richard;
- Matthews, Paul M.;
- Parker, Christine A.
Publication type:
Article
Complement is activated in progressive multiple sclerosis cortical grey matter lesions.
Published in:
2016
By:
- Watkins, Lewis M.;
- Neal, James W.;
- Loveless, Sam;
- Michailidou, Iliana;
- Ramaglia, Valeria;
- Rees, Mark I.;
- Reynolds, Richard;
- Robertson, Neil P.;
- Morgan, B. Paul;
- Howell, Owain W.
Publication type:
journal article
Calorie restriction activates new adult born olfactory‐bulb neurones in a ghrelin‐dependent manner but acyl‐ghrelin does not enhance subventricular zone neurogenesis.
Published in:
Journal of Neuroendocrinology, 2019, v. 31, n. 7, p. N.PAG, doi. 10.1111/jne.12755
By:
- Ratcliff, Michael;
- Rees, Daniel;
- McGrady, Scott;
- Buntwal, Luke;
- Hornsby, Amanda K. E.;
- Bayliss, Jaqueline;
- Kent, Brianne A.;
- Bussey, Timothy;
- Saksida, Lisa;
- Beynon, Amy L.;
- Howell, Owain W.;
- Morgan, Alwena H.;
- Sun, Yuxiang;
- Andrews, Zane B.;
- Wells, Timothy;
- Davies, Jeffrey S.
Publication type:
Article
Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59.
Published in:
Multiple Sclerosis Journal, 2019, v. 25, n. 4, p. 523, doi. 10.1177/1352458518758927
By:
- Zelek, Wioleta M.;
- Watkins, Lewis M.;
- Howell, Owain W.;
- Evans, Rhian;
- Loveless, Sam;
- Robertson, Neil P.;
- Beenes, Marijke;
- Willems, Loek;
- Brandwijk, Ricardo;
- Morgan, B. Paul
Publication type:
Article
Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis.
Published in:
Annals of Neurology, 2024, v. 96, n. 1, p. 1, doi. 10.1002/ana.26913
By:
- Calabrese, Massimiliano;
- Preziosa, Paolo;
- Scalfari, Antonio;
- Colato, Elisa;
- Marastoni, Damiano;
- Absinta, Martina;
- Battaglini, Marco;
- De Stefano, Nicola;
- Di Filippo, Massimiliano;
- Hametner, Simon;
- Howell, Owain W.;
- Inglese, Matilde;
- Lassmann, Hans;
- Martin, Roland;
- Nicholas, Richard;
- Reynolds, Richard;
- Rocca, Maria A.;
- Tamanti, Agnese;
- Vercellino, Marco;
- Villar, Luisa Maria
Publication type:
Article
Comparing the Pathology, Clinical, and Demographic Characteristics of Younger and Older‐Onset Multiple Sclerosis.
Published in:
Annals of Neurology, 2024, v. 95, n. 3, p. 471, doi. 10.1002/ana.26843
By:
- Knowles, Sarah;
- Middleton, Rod;
- Cooze, Benjamin;
- Farkas, Ildiko;
- Leung, Yeung Yeung;
- Allen, Kelsey;
- Winslade, Molly;
- Owen, David R.J.;
- Magliozzi, Roberta;
- Reynolds, Richard;
- Neal, James W.;
- Pearson, Owen;
- Nicholas, Richard;
- Pickrell, W. Owen;
- Howell, Owain W.
Publication type:
Article
"Ependymal-in" Gradient of Thalamic Damage in Progressive Multiple Sclerosis.
Published in:
2022
By:
- Magliozzi, Roberta;
- Fadda, Giulia;
- Brown, Robert A.;
- Bar‐Or, Amit;
- Howell, Owain W.;
- Hametner, Simon;
- Marastoni, Damiano;
- Poli, Alberto;
- Nicholas, Richard;
- Calabrese, Massimiliano;
- Monaco, Salvatore;
- Reynolds, Richard;
- Bar-Or, Amit
Publication type:
journal article
Meningeal inflammation and cortical demyelination in acute multiple sclerosis.
Published in:
2018
By:
- Bevan, Ryan J.;
- Evans, Rhian;
- Griffiths, Lauren;
- Watkins, Lewis M.;
- Rees, Mark I.;
- Magliozzi, Roberta;
- Allen, Ingrid;
- McDonnell, Gavin;
- Kee, Rachel;
- Naughton, Michelle;
- Fitzgerald, Denise C.;
- Reynolds, Richard;
- Neal, James W.;
- Howell, Owain W.
Publication type:
journal article
Inflammatory intrathecal profiles and cortical damage in multiple sclerosis.
Published in:
2018
By:
- Magliozzi, Roberta;
- Howell, Owain W.;
- Nicholas, Richard;
- Cruciani, Carolina;
- Castellaro, Marco;
- Romualdi, Chiara;
- Rossi, Stefania;
- Pitteri, Marco;
- Benedetti, Maria Donata;
- Gajofatto, Alberto;
- Pizzini, Francesca B.;
- Montemezzi, Stefania;
- Rasia, Sarah;
- Capra, Ruggero;
- Bertoldo, Alessandra;
- Facchiano, Francesco;
- Monaco, Salvatore;
- Reynolds, Richard;
- Calabrese, Massimiliano
Publication type:
journal article
A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis.
Published in:
Biomedicines, 2022, v. 10, n. 10, p. N.PAG, doi. 10.3390/biomedicines10102604
By:
- Kee, Rachael;
- Naughton, Michelle;
- McDonnell, Gavin V.;
- Howell, Owain W.;
- Fitzgerald, Denise C.
Publication type:
Article
Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space.
Published in:
Neuropathology & Applied Neurobiology, 2015, v. 41, n. 6, p. 798, doi. 10.1111/nan.12199
By:
- Howell, Owain W.;
- Schulz‐Trieglaff, Elena Katharina;
- Carassiti, Daniele;
- Gentleman, Steven M.;
- Nicholas, Richard;
- Roncaroli, Federico;
- Reynolds, Richard
Publication type:
Article
The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome.
Published in:
Brain Pathology, 2022, v. 32, n. 5, p. 1, doi. 10.1111/bpa.13054
By:
- Cooze, Benjamin J.;
- Dickerson, Matthew;
- Loganathan, Rukshikah;
- Watkins, Lewis M.;
- Grounds, Ethan;
- Pearson, Ben R.;
- Bevan, Ryan Jack;
- Morgan, B. Paul;
- Magliozzi, Roberta;
- Reynolds, Richard;
- Neal, James W.;
- Howell, Owain W.
Publication type:
Article
B cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis.
Published in:
Brain Pathology, 2020, v. 30, n. 4, p. 779, doi. 10.1111/bpa.12841
By:
- Reali, Camilla;
- Magliozzi, Roberta;
- Roncaroli, Federico;
- Nicholas, Richard;
- Howell, Owain W.;
- Reynolds, Richard
Publication type:
Article
Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis.
Published in:
Brain Pathology, 2018, v. 28, n. 4, p. 507, doi. 10.1111/bpa.12546
By:
- Loveless, Sam;
- Neal, James W.;
- Howell, Owain W.;
- Harding, Katharine E.;
- Sarkies, Patrick;
- Evans, Rhian;
- Bevan, Ryan J.;
- Hakobyan, Svetlana;
- Harris, Claire L.;
- Robertson, Neil P.;
- Morgan, Bryan Paul
Publication type:
Article
Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats.
Published in:
Brain: A Journal of Neurology, 2013, v. 136, n. 12, p. 3596, doi. 10.1093/brain/awt279
By:
- Gardner, Christopher;
- Magliozzi, Roberta;
- Durrenberger, Pascal F.;
- Howell, Owain W.;
- Rundle, Jon;
- Reynolds, Richard
Publication type:
Article
Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis.
Published in:
Brain: A Journal of Neurology, 2012, v. 135, n. 10, p. 2925, doi. 10.1093/brain/aws189
By:
- Choi, Sung R.;
- Howell, Owain W.;
- Carassiti, Daniele;
- Magliozzi, Roberta;
- Gveric, Djordje;
- Muraro, Paolo A.;
- Nicholas, Richard;
- Roncaroli, Federico;
- Reynolds, Richard
Publication type:
Article
Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis.
Published in:
Brain: A Journal of Neurology, 2011, v. 134, n. 9, p. 2755, doi. 10.1093/brain/awr182
By:
- Howell, Owain W.;
- Reeves, Cheryl A.;
- Nicholas, Richard;
- Carassiti, Daniele;
- Radotra, Bishan;
- Gentleman, Steve M.;
- Serafini, Barbara;
- Aloisi, Francesca;
- Roncaroli, Federico;
- Magliozzi, Roberta;
- Reynolds, Richard
Publication type:
Article
Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis.
Published in:
Brain: A Journal of Neurology, 2011, v. 134, n. 2, p. 534, doi. 10.1093/brain/awq350
By:
- Lovato, Laura;
- Willis, Simon N.;
- Rodig, Scott J.;
- Caron, Tyler;
- Almendinger, Stefany E.;
- Howell, Owain W.;
- Reynolds, Richard;
- O’Connor, Kevin C.;
- Hafler, David A.
Publication type:
Article
Detection of Epstein–Barr virus and B-cell follicles in the multiple sclerosis brain: what you find depends on how and where you look.
Published in:
Brain: A Journal of Neurology, 2010, v. 133, n. 12, p. e157, doi. 10.1093/brain/awq223
By:
- Aloisi, Francesca;
- Serafini, Barbara;
- Magliozzi, Roberta;
- Howell, Owain W.;
- Reynolds, Richard
Publication type:
Article
NPY augments the proliferative effect of FGF2 and increases the expression of FGFR1 on nestin positive postnatal hippocampal precursor cells, via the Y1 receptor.
Published in:
Journal of Neurochemistry, 2010, v. 113, n. 3, p. 615, doi. 10.1111/j.1471-4159.2010.06633.x
By:
- Rodrigo, Chamira;
- Zaben, Malik;
- Lawrence, Timothy;
- Laskowski, Alexandra;
- Howell, Owain W.;
- Gray, William P.
Publication type:
Article
Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus.
Published in:
Journal of Neurochemistry, 2005, v. 93, n. 3, p. 560, doi. 10.1111/j.1471-4159.2005.03057.x
By:
- Howell, Owain W.;
- Doyle, Kharen;
- Goodman, Jeffrey H.;
- Scharfman, Helen E.;
- Herzog, Herbert;
- Pringle, Ashley;
- Beck-Sickinger, Annette G.;
- Gray, William P.
Publication type:
Article
Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells.
Published in:
Journal of Neurochemistry, 2003, v. 86, n. 3, p. 646, doi. 10.1046/j.1471-4159.2003.01895.x
By:
- Howell, Owain W.;
- Scharfman, Helen E.;
- Herzog, Herbert;
- Sundstrom, Lars E.;
- Beck-Sickinger, Annette;
- Gray, William P.
Publication type:
Article

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