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Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants.
Published in:
Angewandte Chemie, 2019, v. 131, n. 7, p. 2012, doi. 10.1002/ange.201809424
By:
- Lohans, Christopher T.;
- Chan, H. T. Henry;
- Malla, Tika R.;
- Kumar, Kiran;
- Kamps, Jos J. A. G.;
- McArdle, Darius J. B.;
- van Groesen, Emma;
- de Munnik, Mariska;
- Tooke, Catherine L.;
- Spencer, James;
- Paton, Robert S.;
- Brem, Jürgen;
- Schofield, Christopher J.
Publication type:
Article
A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation.
Published in:
Angewandte Chemie, 2018, v. 130, n. 5, p. 1296, doi. 10.1002/ange.201711308
By:
- Lohans, Christopher T.;
- van Groesen, Emma;
- Kumar, Kiran;
- Paton, Robert S.;
- Brem, Jürgen;
- Schofield, Christopher J.;
- Tooke, Catherine L.;
- Spencer, James
Publication type:
Article
Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants.
Published in:
Angewandte Chemie International Edition, 2019, v. 58, n. 7, p. 1990, doi. 10.1002/anie.201809424
By:
- Lohans, Christopher T.;
- Chan, H. T. Henry;
- Malla, Tika R.;
- Kumar, Kiran;
- Kamps, Jos J. A. G.;
- McArdle, Darius J. B.;
- van Groesen, Emma;
- de Munnik, Mariska;
- Tooke, Catherine L.;
- Spencer, James;
- Paton, Robert S.;
- Brem, Jürgen;
- Schofield, Christopher J.
Publication type:
Article
A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation.
Published in:
Angewandte Chemie International Edition, 2018, v. 57, n. 5, p. 1282, doi. 10.1002/anie.201711308
By:
- Lohans, Christopher T.;
- van Groesen, Emma;
- Kumar, Kiran;
- Paton, Robert S.;
- Brem, Jürgen;
- Schofield, Christopher J.;
- Tooke, Catherine L.;
- Spencer, James
Publication type:
Article
Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.
Published in:
ChemMedChem, 2020, v. 15, n. 3, p. 270, doi. 10.1002/cmdc.201900557
By:
- Holt‐Martyn, James P.;
- Chowdhury, Rasheduzzaman;
- Tumber, Anthony;
- Yeh, Tzu‐Lan;
- Abboud, Martine I.;
- Lippl, Kerstin;
- Lohans, Christopher T.;
- Langley, Gareth W.;
- Figg, William;
- McDonough, Michael A.;
- Pugh, Christopher W.;
- Ratcliffe, Peter J.;
- Schofield, Christopher J.
Publication type:
Article
Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.
Published in:
Molecular Microbiology, 2017, v. 106, n. 3, p. 492, doi. 10.1111/mmi.13831
By:
- Calvopiña, Karina;
- Hinchliffe, Philip;
- Brem, Jürgen;
- Heesom, Kate J.;
- Johnson, Samar;
- Cain, Ricky;
- Lohans, Christopher T.;
- Fishwick, Colin W. G.;
- Schofield, Christopher J.;
- Spencer, James;
- Avison, Matthew B.
Publication type:
Article
Characterization of bacterial antimicrobial peptides active against Campylobacter jejuni.
Published in:
Canadian Journal of Chemistry, 2015, v. 93, n. 4, p. 381, doi. 10.1139/cjc-2014-0411
By:
- Lohans, Christopher T.;
- van Belkum, Marco J.;
- Li, Jing;
- Vederas, John C.
Publication type:
Article
A Fluorescence‐Based Assay for Screening β‐Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2.
Published in:
ChemBioChem, 2020, v. 21, n. 3, p. 368, doi. 10.1002/cbic.201900379
By:
- Munnik, Mariska;
- Lohans, Christopher T.;
- Langley, Gareth W.;
- Bon, Corentin;
- Brem, Jürgen;
- Schofield, Christopher J.
Publication type:
Article
Biochemical, Structural, and Genetic Characterization of Tridecaptin A1, an Antagonist of Campylobacter jejuni.
Published in:
ChemBioChem, 2014, v. 15, n. 2, p. 243, doi. 10.1002/cbic.201300595
By:
- Lohans, Christopher T.;
- van Belkum, Marco J.;
- Cochrane, Stephen A.;
- Huang, Zedu;
- Sit, Clarissa S.;
- McMullen, Lynn M.;
- Vederas, John C.
Publication type:
Article
Substitution of a Conserved Disulfide in the Type IIa Bacteriocin, Leucocin A, with L-Leucine and L-Serine Residues: Effects on Activity and Three-Dimensional Structure.
Published in:
ChemBioChem, 2012, v. 13, n. 1, p. 35, doi. 10.1002/cbic.201100634
By:
- Sit, Clarissa S.;
- Lohans, Christopher T.;
- van Belkum, Marco J.;
- Campbell, Chantel D.;
- Miskolzie, Mark;
- Vederas, John C.
Publication type:
Article
Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-49264-0
By:
- Lohans, Christopher T.;
- Freeman, Emily I.;
- Groesen, Emma van;
- Tooke, Catherine L.;
- Hinchliffe, Philip;
- Spencer, James;
- Brem, Jürgen;
- Schofield, Christopher J.
Publication type:
Article
19F NMR Monitoring of Reversible Protein Post‐Translational Modifications: Class D β‐Lactamase Carbamylation and Inhibition.
Published in:
Chemistry - A European Journal, 2019, v. 25, n. 51, p. 11837, doi. 10.1002/chem.201902529
By:
- van Groesen, Emma;
- Lohans, Christopher T.;
- Brem, Jürgen;
- Aertker, Kristina M. J.;
- Claridge, Timothy D. W.;
- Schofield, Christopher J.
Publication type:
Article
Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.
Published in:
Chemistry - A European Journal, 2019, v. 25, n. 8, p. 2019, doi. 10.1002/chem.201804790
By:
- Thinnes, Cyrille C.;
- Lohans, Christopher T.;
- Abboud, Martine I.;
- Yeh, Tzu‐Lan;
- Tumber, Anthony;
- Nowak, Radosław P.;
- Attwood, Martin;
- Cockman, Matthew E.;
- Oppermann, Udo;
- Loenarz, Christoph;
- Schofield, Christopher J.
Publication type:
Article
Structural characterization of thioether-bridged bacteriocins.
Published in:
Journal of Antibiotics, 2014, v. 67, n. 1, p. 23, doi. 10.1038/ja.2013.81
By:
- Lohans, Christopher T;
- Vederas, John C
Publication type:
Article
Development of Class IIa Bacteriocins as Therapeutic Agents.
Published in:
International Journal of Microbiology, 2012, p. 1, doi. 10.1155/2012/386410
By:
- Lohans, Christopher T.;
- Vederas, John C.
Publication type:
Article
Identification and three-dimensional structure of carnobacteriocin XY, a class IIb bacteriocin produced by Carnobacteria.
Published in:
FEBS Letters, 2017, v. 591, n. 10, p. 1349, doi. 10.1002/1873-3468.12648
By:
- Acedo, Jeella Z.;
- Towle, Kaitlyn M.;
- Lohans, Christopher T.;
- Miskolzie, Mark;
- McKay, Ryan T.;
- Doerksen, Thomas A.;
- Vederas, John C.;
- Martin-Visscher, Leah A.
Publication type:
Article

Found: 16

Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants.

A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation.

Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants.

A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation.

Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.

Characterization of bacterial antimicrobial peptides active against Campylobacter jejuni.

A Fluorescence‐Based Assay for Screening β‐Lactams Targeting the Mycobacterium tuberculosis Transpeptidase Ldt<sub>Mt2</sub>.

Biochemical, Structural, and Genetic Characterization of Tridecaptin A<sub>1</sub>, an Antagonist of Campylobacter jejuni.

Substitution of a Conserved Disulfide in the Type IIa Bacteriocin, Leucocin A, with L-Leucine and L-Serine Residues: Effects on Activity and Three-Dimensional Structure.

Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation.

<sup>19</sup>F NMR Monitoring of Reversible Protein Post‐Translational Modifications: Class D β‐Lactamase Carbamylation and Inhibition.

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.

Structural characterization of thioether-bridged bacteriocins.

Development of Class IIa Bacteriocins as Therapeutic Agents.

Identification and three-dimensional structure of carnobacteriocin XY, a class IIb bacteriocin produced by Carnobacteria.