Results
Title

The role of telomerase in hair growth and relevant disorders: A review.

Authors

Wang, Chaofan; Bi, Lingbo; Du, Yimei; Lu, Changpei; Zhao, Min; Lin, Xuewen; Ding, Yunbu; Fan, Weixin

Abstract

Background: Hair diseases may present with hair loss, hirsutism, hair melanin abnormalities and other manifestations. Hair follicles are known as mini‐organs that undergo periodic remodeling, and their constant regeneration in vivo reflects interesting anti‐aging functions. Telomerase prevents cellular senescence by maintaining telomere length, but its excessive proliferation in cancer cells may also induce cancer. However, the effects of telomerase in hair growth have rarely been reported. Methods: In this study, we reviewed the role of telomerase in hair growth and the effects of hair disorders through literature search and analysis. Results: There is growing evidence that telomerase plays an important role in maintaining hair follicle function and proliferation. Changes in telomerase levels in hair follicles have also been found in a variety of hair disorders. Conclusion: Telomerase plays a positive role in hair growth and is expected to become a new target for the treatment of alopecia or other hair diseases in the future.

Subjects

HAIR growth; TELOMERASE; GROWTH disorders; HAIR diseases; HAIR follicles

Publication

Journal of Cosmetic Dermatology, 2023, Vol 22, Issue 11, p2925

ISSN

1473-2130

Publication type

Academic Journal

DOI

10.1111/jocd.15992