Evaluation of platelet‐rich plasma plus basic fibroblast growth factor combined with minoxidil in the treatment of androgenetic alopecia: A randomized controlled trial.

Wu, Shulian; Liu, Shizhao; Chen, Jian; Dai, Damao; Liu, Weijie; Le, Demengjie; Guan, Qing; Miao, Yong; Hu, Zhiqi; Qu, Qian

Background: Platelet‐rich plasma plus basic fibroblast growth factor (PRPF) has been confirmed to be a safe and valuable therapy for androgenetic alopecia (AGA). However, the efficacy of PRPF combined with minoxidil treatment remains unknown. Objective: To assess the efficacy of combined PRPF and minoxidil treatment for AGA. Methods: In this prospective, randomized controlled trial, 75 patients with AGA were randomly divided into three groups and were administered the following treatments: Group 1, direct intradermal PRPF injection; Group 2, topical minoxidil 5% twice daily; and Group 3, PRPF injection combined with minoxidil. The PRPF injection was performed three times, 1 month apart. Hair growth parameters were evaluated using a trichoscope until the sixth month of the study. Patient satisfaction and side effects were recorded during the follow‐up. Results: All patients showed improvements (p < 0.05) in hair count, terminal hair, and decrease in telogen hair ratio after treatment. The efficacy of PRPF complex therapy revealed significant improvements (p < 0.05) in hair count, terminal hair and growth rate, compared with monotherapy. Limitations: Small sample size, short follow‐up time and lack of quantification of GFs in PRPF. Conclusion: The effect of complex therapy exceed both the effects of PRPF monotherapy and minoxidil treatment, which can be a beneficial AGA treatment strategy.

FIBROBLAST growth factor 2; PLATELET-rich plasma; MINOXIDIL; RANDOMIZED controlled trials; HAIR transplantation; HAIR removal; HAIR growth

Journal of Cosmetic Dermatology, 2023, Vol 22, Issue 7, p1995

1473-2130

Academic Journal

10.1111/jocd.15825