Therapeutic efficacy of metronidazole by needle‐free jet injection combined with blue light therapy in Moderate‐to‐Severe facial acne vulgaris.

Yi, Lu; Gao, Lihua; Lv, Lv; Zhang, Bo; Chen, Fangru; Yang, Fengyuan; Yan, Wenjie; Jiang, Lijun; Li, Nianzhen; Lao, Yuanqing; Lu, Jianyun; Huang, Xi

Background: Acne vulgaris is one of the most common dermatological diseases. Some topical treatments for acne used in combination, such as blue light and topical antibiotics (such as metronidazole) by needle‐free jet injection (NFJI), are becoming prevalent in clinical practice, but the efficacy remains uncertain. Methods: In order to investigate the effect of blue light combined with metronidazole by NFJI in the treatment of acne, the 251 enrolled patients were randomly assigned into the blue light group, metronidazole (MNZ) group, and MNZ blue light group, and then received 6‐weeks' treatment. A variety of objective and subjective methods such as clinical pictures, skin barrier physiological parameters (including trans‐epidermal water loss (TEWL), stratum corneum hydration, facail surface sebum, erythema and pigmentation), the Investigator Global Assessment score, acne lesion count assessment, Patients' Self‐Assessment, and VAS score were used to evaluate the efficacy and side effects of the treatments. Results: Compared to the baseline, the MNZ blue light group showed significant improvement in acne lesion count reduction, TEWL, straum corneum hydration, facial surface sebum and erythema (p 0.05). Conclusion: The combination of MNZ by NFJI and blue light has a synergistic effect and can relieve acne skin lesion within 6 weeks in the treatment of moderate and moderate–to–severe facial acne vulgaris, meanwhile, this method has a good safety.

BLUE light; PHOTOTHERAPY; TREATMENT effectiveness; ACNE; METRONIDAZOLE; ROSACEA

Journal of Cosmetic Dermatology, 2023, Vol 22, Issue 2, p569

1473-2130

Academic Journal

10.1111/jocd.15442