Works matching DE "INFLAMMASOMES"

Results: 2684

Chronic Anatabine Administration Attenuates Cardiovascular Activity by Targeting NF-κB/NLRP3/Caspase-1-Dependent Pyroptosis and Oxidative Stress in Paraventricular Nucleus of Hypertensive Rat.

Published in:

Cardiovascular Toxicology, 2025, v. 25, n. 9, p. 1352, doi. 10.1007/s12012-025-10034-2

By:

Su, Qing;
Li, Shao-Jun;
Zhou, Jun-Yu;
Yang, Jin-Bao;
Zhao, Fang;
Zou, Guo-Quan;
Ma, Jia-Xuan;
Liu, Qi;
Feng, Yuan-Yuan;
Yang, Cui-Ling;
Li, Ying;
Li, Hong-Bao;
Xu, Meng-Lu

Publication type:

Article

Unleashing the potential of exercise: conquering cardiovascular disease by targeting inflammasome activation.

Published in:

European Journal of Medical Research, 2025, v. 30, n. 1, p. 1, doi. 10.1186/s40001-025-02927-3

By:

Xiang, Lijuan;
Su, Zhanguo

Publication type:

Article

Molecular Mechanism of NLRP3 Inflammasome in Inflammatory Diseases and Tumors.

Published in:

Immunity, Inflammation & Disease, 2025, v. 13, n. 7, p. 1, doi. 10.1002/iid3.70213

By:

Gong, Le‐Lan;
Zhou, He‐Jiang;
Zhao, Quan‐Ming;
Xu, Ning;
Huang, Feng‐Chang;
Su, Ling‐Yan;
Li, Wen‐Liang

Publication type:

Article

C-Myc Reduces Oxygen-Glucose Deprivation/Reperfusion-Induced Neuronal Pyroptosis through the SRSF1/NLRP1 Axis.

Published in:

Biocell, 2025, v. 49, n. 7, p. 1245, doi. 10.32604/biocell.2025.064396

By:

Liu, Siliang;
Tang, Hong;
Xia, Ying;
Yu, Zhengtao;
Gao, Ning

Publication type:

Article

Role of rosuvastatin and pitavastatin in alleviating diabetic cardiomyopathy in rats: Targeting of RISK, NF-κB/ NLRP3 inflammasome and TLR4/ NF-κB signaling cascades.

Published in:

PLoS ONE, 2025, v. 20, n. 7, p. 1, doi. 10.1371/journal.pone.0325767

By:

Saleh, Dalia O.;
Abo El Nasr, Nesma M.E.;
Elbaset, Marawan A.;
Shabana, Marwa E.;
Esatbeyoglu, Tuba;
Afifi, Sherif M.;
Hashad, Ingy M.

Publication type:

Article

Iguratimod Alleviates Experimental Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation.

Published in:

Cell Biochemistry & Biophysics, 2024, v. 82, n. 3, p. 2275, doi. 10.1007/s12013-024-01337-2

By:

Zhang, Qi;
Yang, Xi-Rui;
Deng, Yao

Publication type:

Article

Astragalus Polysaccharides Reduce High-glucose-induced Rat Aortic Endothelial Cell Senescence and Inflammasome Activation by Modulating the Mitochondrial Na+/Ca2+ Exchanger.

Published in:

Cell Biochemistry & Biophysics, 2022, v. 80, n. 2, p. 341, doi. 10.1007/s12013-021-01058-w

By:

Miao, Xin-Yu;
Zhu, Xiao-Xiao;
Gu, Zhao-Yan;
Fu, Bo;
Cui, Shao-Yuan;
Zu, Yuan;
Rong, Ling-Jun;
Hu, Fan;
Chen, Xiang-Mei;
Gong, Yan-Ping;
Li, Chun-Lin

Publication type:

Article

Arsenic Activates the NLRP3 Inflammasome and Disturbs the Th1/Th2/Th17/Treg Balance in the Hippocampus in Mice.

Published in:

Biological Trace Element Research, 2023, v. 201, n. 7, p. 3395, doi. 10.1007/s12011-022-03421-1

By:

Jing, Hui;
Yan, Nan;
Fan, Ronghua;
Li, Zhou;
Wang, Qian;
Xu, Kangjie;
Hu, Xinkang;
Zhang, Lifeng;
Duan, Xiaoxu

Publication type:

Article

Selenium Ameliorates S. aureus-Induced Inflammation in Bovine Mammary Epithelial Cells by Regulating ROS-Induced NLRP3 Inflammasome.

Published in:

Biological Trace Element Research, 2022, v. 200, n. 7, p. 3171, doi. 10.1007/s12011-021-02924-7

By:

Yang, Yan;
Lv, Shenjin;
Wang, Zhennan;
Liu, Junjun

Publication type:

Article

The Prospective Ameliorative Role of Zinc Oxide Nanoparticles in STZ-Induced Diabetic Nephropathy in Rats: Mechanistic Targeting of Autophagy and Regulating Nrf2/TXNIP/NLRP3 Inflammasome Signaling.

Published in:

Biological Trace Element Research, 2022, v. 200, n. 4, p. 1677, doi. 10.1007/s12011-021-02773-4

By:

Abd El-Khalik, Sarah Ragab;
Nasif, Elham;
Arakeep, Heba M.;
Rabah, Hanem

Publication type:

Article

Selenium Attenuates S. aureus-Induced Inflammation by Regulation TLR2 Signaling Pathway and NLRP3 Inflammasome in RAW 264.7 Macrophages.

Published in:

Biological Trace Element Research, 2022, v. 200, n. 2, p. 761, doi. 10.1007/s12011-021-02676-4

By:

Wei, Ming-Ji;
Wang, Zhen-Nan;
Yang, Yan;
Zhang, Shu-Jiu;
Tang, He;
Li, Hui;
Bi, Chong-Liang

Publication type:

Article

Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway.

Published in:

Biological Trace Element Research, 2021, v. 199, n. 9, p. 3423, doi. 10.1007/s12011-020-02471-7

By:

Fang, Yuanyuan;
Peng, Dongjie;
Liang, Yuan;
Lu, Lili;
Li, Junyan;
Zhao, Lin;
Ou, Shiyan;
Li, Shaojun;
Aschner, Michael;
Jiang, Yueming

Publication type:

Article

Methylation Status of the miR-141-3p Promoter Regulates miR-141-3p Expression, Inflammasome Formation, and the Invasiveness of HTR-8/SVneo Cells.

Published in:

Cytogenetic & Genome Research, 2022, v. 161, n. 10/11, p. 501, doi. 10.1159/000519740

By:

Wu, Dongcai;
Shi, Li;
Chen, Fangrong;
Lin, Qing;
Kong, Jiao

Publication type:

Article

Absent in melanoma 2 regulates tumor cell proliferation in glioblastoma multiforme.

Published in:

Journal of Neuro-Oncology, 2019, v. 144, n. 2, p. 265, doi. 10.1007/s11060-019-03230-y

By:

Chen, P. A.;
Shrivastava, G.;
Balcom, E. F.;
McKenzie, B. A.;
Fernandes, J.;
Branton, W. G.;
Wheatley, B. M.;
Petruk, K.;
van Landeghem, F. K. H.;
Power, Christopher

Publication type:

Article

The Selective NLRP3-inflammasome inhibitor MCC950 Mitigates Post-resuscitation Myocardial Dysfunction and Improves Survival in a Rat Model of Cardiac Arrest and Resuscitation.

Published in:

Cardiovascular Drugs & Therapy, 2023, v. 37, n. 3, p. 423, doi. 10.1007/s10557-021-07282-z

By:

Zheng, Guanghui;
He, Fenglian;
Xu, Jing;
Hu, Juntao;
Ge, Weiwei;
Ji, Xianfei;
Wang, Changsheng;
Bradley, Jennifer L.;
Peberdy, Mary Ann;
Ornato, Joseph P.;
Jiang, Longyuan;
Toldo, Stefano;
Wang, Tong;
Tang, Wanchun

Publication type:

Article

miR-330-5p inhibits NLRP3 inflammasome-mediated myocardial ischaemia–reperfusion injury by targeting TIM3.

Published in:

Cardiovascular Drugs & Therapy, 2021, v. 35, n. 4, p. 691, doi. 10.1007/s10557-020-07104-8

By:

Zuo, Wei;
Tian, Ran;
Chen, Qian;
Wang, Lun;
Gu, Qing;
Zhao, Hongmei;
Huang, Chunmei;
Liu, Yingxian;
Li, Jingyi;
Yang, Xinglin;
Xu, Lihong;
Zhang, Bo;
Liu, Zhenyu

Publication type:

Article

Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes.

Published in:

Cardiovascular Drugs & Therapy, 2018, v. 32, n. 2, p. 135, doi. 10.1007/s10557-018-6778-x

By:

Birnbaum, Yochai;
Bajaj, Mandeep;
Yang, Hsiu-Chiung;
Ye, Yumei

Publication type:

Article

SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor.

Published in:

Cardiovascular Drugs & Therapy, 2017, v. 31, n. 2, p. 119, doi. 10.1007/s10557-017-6725-2

By:

Ye, Yumei;
Bajaj, Mandeep;
Yang, Hsiu-Chiung;
Perez-Polo, Jose;
Birnbaum, Yochai

Publication type:

Article

Xanthine Oxidase Induces Foam Cell Formation through LOX-1 and NLRP3 Activation.

Published in:

Cardiovascular Drugs & Therapy, 2017, v. 31, n. 1, p. 19, doi. 10.1007/s10557-016-6706-x

By:

Dai, Yao;
Cao, Yongxiang;
Zhang, Zhigao;
Vallurupalli, Srikanth;
Mehta, Jawahar

Publication type:

Article

Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats.

Published in:

Molecular Medicine, 2019, v. 25, n. 1, p. N.PAG, doi. 10.1186/s10020-019-0091-4

By:

Jiang, Tao;
Wu, Meiyan;
Zhang, Zhanqin;
Yan, Chaoying;
Ma, Zhi;
He, Shan;
Yuan, Wei;
Pu, Kairui;
Wang, Qiang

Publication type:

Article

Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity.

Published in:

Molecular Medicine, 2018, v. 24, n. 1, p. 1, doi. 10.1186/s10020-018-0006-9

By:

Sujun Li;
Fang Liang;
Kwan, Kevin;
Yiting Tang;
Xiangyu Wang;
Youzhou Tang;
Jianhua Li;
Huan Yang;
Chavan, Sangeeta S.;
Haichao Wang;
Andersson, Ulf;
Ben Lu;
Tracey, Kevin J.

Publication type:

Article

Sex- and Disease-Specific Inflammasome Signatures in Circulating Blood Leukocytes of Patients with Abdominal Aortic Aneurysm.

Published in:

Molecular Medicine, 2016, v. 22, n. 1, p. 508, doi. 10.2119/molmed.2016.00035

By:

Wu, Xiaoyu;
Cakmak, Sinan;
Wortmann, Markus;
Hakimi, Maani;
Zhang, Jian;
Böckler, Dittmar;
Dihlmann, Susanne

Publication type:

Article

Sex- and Disease-Specific Inflammasome Signatures in Circulating Blood Leukocytes of Patients with Abdominal Aortic Aneurysm.

Published in:

Molecular Medicine, 2016, v. 22, p. 508, doi. 10.2119/molmed.2016.00035

By:

Xiaoyu Wu;
Sinan Cakmak;
Markus Wortmann;
Maani Hakimi;
Jian Zhang;
Böckler, Dittmar;
Dihlmann, Susanne

Publication type:

Article

The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation.

Published in:

Journal of Cancer Research & Clinical Oncology, 2023, v. 149, n. 7, p. 3729, doi. 10.1007/s00432-022-04284-8

By:

Cambui, Raylane Adrielle Gonçalves;
Fernandes, Fernanda Pereira;
Leal, Vinicius Nunes Cordeiro;
Reis, Edione Cristina;
de Lima, Dhemerson Souza;
do Espírito Santo, Gilmar Ferreira;
Elias, Rosa Maria;
Pontillo, Alessandra

Publication type:

Article

Inflammation suppresses DLG2 expression decreasing inflammasome formation.

Published in:

Journal of Cancer Research & Clinical Oncology, 2022, v. 148, n. 9, p. 2295, doi. 10.1007/s00432-022-04029-7

By:

Keane, Simon;
Herring, Matthew;
Rolny, Peter;
Wettergren, Yvonne;
Ejeskär, Katarina

Publication type:

Article

Curcuma phaeocaulis Inhibits NLRP3 Inflammasome in Macrophages and Ameliorates Nanoparticle-Induced Airway Inflammation in Mice.

Published in:

Molecules, 2022, v. 27, n. 7, p. 2101, doi. 10.3390/molecules27072101

By:

Nam, Yeon-Ju;
Choi, Jiwon;
Lee, Jong Suk;
Seo, Changon;
Lee, Gyeongbeen;
Lee, Youngsu;
Kim, Jin Kyu;
Kim, Pansoo;
Lim, Jeong Ju;
Choi, Hyeon-Son;
Choi, Yongmun

Publication type:

Article

Inflammasome Inhibitors.

Published in:

Molecules, 2021, v. 26, n. 22, p. 6912, doi. 10.3390/molecules26226912

By:

Bertinaria, Massimo

Publication type:

Article

Inhibitory Role of Berberine, an Isoquinoline Alkaloid, on NLRP3 Inflammasome Activation for the Treatment of Inflammatory Diseases.

Published in:

Molecules, 2021, v. 26, n. 20, p. 6238, doi. 10.3390/molecules26206238

By:

Sarbadhikary, Paromita;
George, Blassan P.;
Abrahamse, Heidi

Publication type:

Article

Palonosetron/Methyllycaconitine Deactivate Hippocampal Microglia 1, Inflammasome Assembly and Pyroptosis to Enhance Cognition in a Novel Model of Neuroinflammation.

Published in:

Molecules, 2021, v. 26, n. 16, p. 5068, doi. 10.3390/molecules26165068

By:

Mohamed, Reem A.;
Abdallah, Dalaal M.;
El-brairy, Amany I.;
Ahmed, Kawkab A.;
El-Abhar, Hanan S.

Publication type:

Article

Promise of the NLRP3 Inflammasome Inhibitors in In Vivo Disease Models.

Published in:

Molecules, 2021, v. 26, n. 16, p. 4996, doi. 10.3390/molecules26164996

By:

Das, Biswadeep;
Sarkar, Chayna;
Rawat, Vikram Singh;
Kalita, Deepjyoti;
Deka, Sangeeta;
Agnihotri, Akash

Publication type:

Article

Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2 H -benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor.

Published in:

Molecules, 2021, v. 26, n. 13, p. 3975, doi. 10.3390/molecules26133975

By:

Gastaldi, Simone;
Boscaro, Valentina;
Gianquinto, Eleonora;
Sandall, Christina F.;
Giorgis, Marta;
Marini, Elisabetta;
Blua, Federica;
Gallicchio, Margherita;
Spyrakis, Francesca;
MacDonald, Justin A.;
Bertinaria, Massimo

Publication type:

Article

Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177 ® (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction.

Published in:

Molecules, 2021, v. 26, n. 12, p. 3534, doi. 10.3390/molecules26123534

By:

Aliaga, Joseph;
Bonaventura, Aldo;
Mezzaroma, Eleonora;
Dhakal, Yogesh;
Mauro, Adolfo Gabriele;
Abbate, Antonio;
Toldo, Stefano

Publication type:

Article

Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease.

Published in:

Molecules, 2021, v. 26, n. 6, p. 1725, doi. 10.3390/molecules26061725

By:

Xu, Qiuyun;
Zhou, Xiaorong;
Strober, Warren;
Mao, Liming;
Bertinaria, Massimo

Publication type:

Article

Techniques to Study Inflammasome Activation and Inhibition by Small Molecules.

Published in:

Molecules, 2021, v. 26, n. 6, p. 1704, doi. 10.3390/molecules26061704

By:

Angosto-Bazarra, Diego;
Molina-López, Cristina;
Peñín-Franch, Alejandro;
Hurtado-Navarro, Laura;
Pelegrín, Pablo;
Bertinaria, Massimo;
de-las-Heras, Beatriz

Publication type:

Article

Inflammasomes and the Maintenance of Hematopoietic Homeostasis: New Perspectives and Opportunities.

Published in:

Molecules, 2021, v. 26, n. 2, p. 309, doi. 10.3390/molecules26020309

By:

Yang, Lijing;
Hu, Mengjia;
Lu, Yukai;
Han, Songling;
Wang, Junping;
Bertinaria, Massimo;
Ciceco, Iola F. Duarte

Publication type:

Article

Heterotypic Supramolecular Hydrogels Formed by Noncovalent Interactions in Inflammasomes.

Published in:

Molecules, 2021, v. 26, n. 1, p. 77, doi. 10.3390/molecules26010077

By:

Shy, Adrianna N.;
Wang, Huaimin;
Feng, Zhaoqianqi;
Xu, Bing;
Medina, Scott H.

Publication type:

Article

Inhibiting the NLRP3 Inflammasome.

Published in:

Molecules, 2020, v. 25, n. 23, p. 5533, doi. 10.3390/molecules25235533

By:

El-Sharkawy, Lina Y.;
Brough, David;
Freeman, Sally;
Bertinaria, Massimo

Publication type:

Article

Does NLRP3 Inflammasome and Aryl Hydrocarbon Receptor Play an Interlinked Role in Bowel Inflammation and Colitis-Associated Colorectal Cancer?

Published in:

Molecules, 2020, v. 25, n. 10, p. 2427, doi. 10.3390/molecules25102427

By:

Ngui, Ivan Qi Han;
Perera, Agampodi Promoda;
Eri, Rajaraman;
Bertinaria, Massimo

Publication type:

Article

Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of Ainsliaea yunnanensis.

Published in:

Molecules, 2019, v. 24, n. 9, p. 1701, doi. 10.3390/molecules24091701

By:

Li, Jinjie;
Li, Xiuting;
Wang, Xin;
Zhong, Xiangjian;
Ji, Linlin;
Guo, Zihan;
Liu, Yiran;
Shang, Xiaoya

Publication type:

Article

Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through Inactivation of Inflammasome.

Published in:

Molecules, 2019, v. 24, n. 6, p. 1154, doi. 10.3390/molecules24061154

By:

Liu, Ting;
Zeng, Qingxuan;
Zhao, Xiaoqiang;
Wei, Wei;
Li, Yinghong;
Deng, Hongbin;
Song, Danqing;
Mangoni, Arduino A.

Publication type:

Article

Protective Effects of Nintedanib against Polyhexamethylene Guanidine Phosphate-Induced Lung Fibrosis in Mice.

Published in:

Molecules, 2018, v. 23, n. 8, p. 1974, doi. 10.3390/molecules23081974

By:

Wong, Wai Shiu Fred;
Joen, Doin;
Kim, Hyeon-Young;
Kim, Sung-Hwan;
Lee, Kyuhong;
Kim, Min-Seok

Publication type:

Article

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice.

Published in:

Molecules, 2018, v. 23, n. 3, p. 522, doi. 10.3390/molecules23030522

By:

Zhai, Yadong;
Meng, Xiangbao;
Ye, Tianyuan;
Xie, Weijie;
Sun, Guibo;
Sun, Xiaobo

Publication type:

Article

Comparison of Inhibitory Capacities of 6-, 8- and 10-Gingerols/Shogaols on the Canonical NLRP3 Inflammasome-Mediated IL-1 β Secretion.

Published in:

Molecules, 2018, v. 23, n. 2, p. 466, doi. 10.3390/molecules23020466

By:

Ho, Su-Chen;
Chang, Yi-Huang

Publication type:

Article

The Inhibitory Effects of Purple Sweet Potato Color on Hepatic Inflammation Is Associated with Restoration of NAD+ Levels and Attenuation of NLRP3 Inflammasome Activation in High-Fat-Diet-Treated Mice.

Published in:

Molecules, 2017, v. 22, n. 8, p. 1315, doi. 10.3390/molecules22081315

By:

Xin Wang;
Zi-Feng Zhang;
Gui-Hong Zheng;
Ai-Min Wang;
Chun-Hui Sun;
Su-Ping Qin;
Juan Zhuang;
Jun Lu;
Dai-Fu Ma;
Yuan-Lin Zheng

Publication type:

Article

Structure-Antioxidative and Anti-Inflammatory Activity Relationships of Purpurin and Related Anthraquinones in Chemical and Cell Assays.

Published in:

Molecules, 2017, v. 22, n. 2, p. 265, doi. 10.3390/molecules22020265

By:

Woo Nam;
Sung Phil Kim;
Seok Hyun Nam;
Friedman, Mendel

Publication type:

Article

Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and Analogs Targeting the NLRP3 Inflammasome.

Published in:

Molecules, 2017, v. 22, n. 2, p. 213, doi. 10.3390/molecules22020213

By:

Liangkun Pan;
Nan Hang;
Chao Zhang;
Yu Chen;
Shuchun Li;
Yang Sun;
Zhongjun Li;
Xiangbao Meng

Publication type:

Article

Inflammasome activation in melanoma progression: the latest update concerning pathological role and therapeutic value.

Published in:

2025

By:

Pluetrattanabha, Nakaraj;
Direksunthorn, Thanyaporn;
Ahmad, Irfan;
Jyothi, S. Renuka;
Shit, Debasish;
Singh, Anurag Kumar;
Chauhan, Ashish Singh

Publication type:

Literature Review

The role of NLRP1 and NLRP3 inflammasomes in the etiopathogeneses of pityriasis lichenoides chronica and mycosis fungoides: an immunohistochemical study.

Published in:

Archives of Dermatological Research, 2023, v. 315, n. 2, p. 231, doi. 10.1007/s00403-022-02363-x

By:

Bostan, Ecem;
Gokoz, Ozay;
Atakan, Nilgun

Publication type:

Article

Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2018, v. 51, n. 2, p. 1585

By:

Lian, Dawei;
Lai, Jieqing;
Wu, Yanjiao;
Wang, Lei;
Chen, Yongjun;
Zhang, Yang;
Boini, Krishna M.;
Huang, Yi;
Chen, Yang

Publication type:

Article

Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2018, v. 50, n. 4, p. 1585, doi. 10.1159/000494656

By:

Dawei Lian;
Jieqing Lai;
Yanjiao Wu;
Lei Wang;
Yongjun Chen;
Yang Zhang;
Boini, Krishna M.;
Yi Huang;
Yang Chen

Publication type:

Article