A 70-year-old man presented with malaise, heartburn, and sudden eruption of multiple seborrheic keratoses on the back (Fig.). However, this phenomenon is also named as the sign of Leser-Trélat and may herald internal malignancies such as gastrointestinal adenocarcinoma, colon cancer, breast cancer, and lung cancer. GLO:EUW/01dec19:jgh14727-fig-0001.jpg PHOTO (COLOR): 1 Eruption of multiple seborrheic keratoses on the back associated with gastric adenocarcinoma (sign of Leser-Trélat). gl.