Clinical outcomes of cryptogenic compared with non-cryptogenic cirrhosis: A retrospective cohort study.

Mohammed, Omar Kadhim; Mahadeva, Sanjiv

Background and Aim The consequences of the association between the metabolic syndrome and cryptogenic cirrhosis are uncertain. We aimed to compare the differences in clinical outcomes between cryptogenic and non-cryptogenic cirrhosis. Methods A retrospective cohort study was conducted in a large, single academic center, over a 5-year duration. Results Complete data were available in 301 patients with cirrhosis (cryptogenic n = 94, non-cryptogenic n = 207). Compared with non-cryptogenic cirrhosis, patients with cryptogenic cirrhosis were older (mean age 66.4 ± 12.5 vs 60.7 ± 11.3 years, P < 0.0001), had more females (43.6% vs 26.6%, P = 0.003), had less disease severity ( Child- Pugh C 8.5% vs 15.9%, P = 0.042), and had a higher prevalence of the metabolic syndrome (83% vs 51.2%, P < 0.0001). During the 5-year period, adults with cryptogenic Child- Pugh A cirrhosis had a longer total hospital admission duration compared with non-cryptogenic cirrhosis (median 7.0 vs 3.0 days, P = 0.035), but this was less evident in patients with more advanced disease. This difference was due to a longer duration of hospitalization for non-liver-related morbidity (median 14.0 days vs 8.0 days, P = 0.04), rather than liver-related morbidity (median 10.5 days vs 8.0 days, P = 0.34), in patients with cryptogenic compared with non-cryptogenic cirrhosis. Kaplan- Meier survival analysis showed no significant differences in survival between both types of cirrhosis for all grades of severity. Conclusions Cryptogenic cirrhosis is associated with a longer duration of hospitalization compared with non-cryptogenic cirrhosis at an early stage of the disease. This difference is due to a greater burden of non-liver-related complications in the former.

CRYPTOGENIC organizing pneumonia; CIRRHOSIS of the liver; SEVERITY of illness index; LIVER diseases; METABOLIC syndrome; DIAGNOSIS; PATIENTS

Journal of Gastroenterology & Hepatology, 2015, Vol 30, Issue 9, p1423

0815-9319

Academic Journal

10.1111/jgh.12978