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- Title
Hesperidin-mediated expression of Nrf2 and upregulation of antioxidant status in senescent rat heart.
- Authors
Elavarasan, Jayasudha; Velusamy, Prema; Ganesan, Thellamudhu; Ramakrishnan, Suresh Krishna; Rajasekaran, Devaraja; Periandavan, Kalaiselvi
- Abstract
Objectives Oxidative stress is recognized as a key element responsible for the development of age-related pathologies. A declining endogenous defence system during senescence dictates the need for supplementation with exogenous antioxidants through diet. Hesperidin is a naturally occurring flavonone present in citrus fruits and has been shown to have many biological properties, including antioxidant activity. We investigated whether hesperidin supplementation could be valuable in protecting cardiac tissue of aged rats against age-related increase in oxidative stress, as well as the mechanism by which it can boost the antioxidant status of the cell. Methods The activity of antioxidant enzymes, mRNA expression of Nrf2, protein levels of superoxide dismutase and catalase were measured using standard protocols. Key findings Hesperidin treatment effectively protected aged rat heart by increasing the activity of enzymic antioxidants. Hesperidin upregulated the protein levels of nuclear factor erythroid 2-related factor 2, which is responsible for maintaining the antioxidant status of the cell. Conclusions Hesperidin could be useful in protecting cardiomyocytes against age-related increase in oxidative stress mediated by Nrf2 upregulation.
- Subjects
HESPERIDIN; ANTIOXIDANTS; LABORATORY rats; BIOFLAVONOIDS; FLAVONOIDS
- Publication
Journal of Pharmacy & Pharmacology, 2012, Vol 64, Issue 10, p1472
- ISSN
0022-3573
- Publication type
Academic Journal
- DOI
10.1111/j.2042-7158.2012.01512.x