Works matching DE "STRUCTURE-activity relationship in pharmacology"

Results: 398

Identifizierung und Strukturbestimmung eines niedermolekularen Aktivators der LFA-1/ICAM-1-Bindung.

Published in:

Angewandte Chemie, 2014, v. 126, n. 17, p. 4410, doi. 10.1002/ange.201310240

By:

Hintersteiner, Martin;
Kallen, Jörg;
Schmied, Mario;
Graf, Christine;
Jung, Thomas;
Mudd, Gemma;
Shave, Steven;
Gstach, Hubert;
Auer, Manfred

Publication type:

Article

Impedance technology reveals correlations between cytotoxicity and lipophilicity of mono and bimetallic phosphine complexes.

Published in:

BioMetals, 2015, v. 28, n. 4, p. 653, doi. 10.1007/s10534-015-9851-y

By:

Fonteh, P.;
Elkhadir, A.;
Omondi, B.;
Guzei, I.;
Darkwa, J.;
Meyer, D.

Publication type:

Article

Highly potent and selective inhibition of varicella-zoster virus replication by bicyclic furo[2,3-d]pyrimidine nucleoside analogues (This work was presented at the Symposium on Non-HIV Antivirals at the 224th American Chemical Society Meeting at Boston, MA, August 1822, 2002.)

Published in:

Medicinal Research Reviews, 2003, v. 23, n. 3, p. 253, doi. 10.1002/med.10035

By:

Erik De Clercq

Publication type:

Article

SAR study of tyrosine-chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines.

Published in:

Amino Acids, 2012, v. 43, n. 2, p. 923, doi. 10.1007/s00726-011-1152-3

By:

Descôteaux, Caroline;
Brasseur, Kevin;
Leblanc, Valérie;
Parent, Sophie;
Asselin, Éric;
Bérubé, Gervais

Publication type:

Article

Structural and functional insights into polymorphic enzymes of cytochrome P450 2C8.

Published in:

Amino Acids, 2011, v. 40, n. 4, p. 1195, doi. 10.1007/s00726-010-0743-8

By:

Jiang, Hualin;
Zhong, Fangfang;
Sun, Lu;
Feng, Weiyue;
Huang, Zhong-Xian;
Tan, Xiangshi

Publication type:

Article

Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis.

Published in:

Bioinformatics, 2014, v. 30, n. 17, p. i497, doi. 10.1093/bioinformatics/btu456

By:

Khan, Suleiman A.;
Virtanen, Seppo;
Kallioniemi, Olli P.;
Wennerberg, Krister;
Poso, Antti;
Kaski, Samuel

Publication type:

Article

e-Drug3D: 3D structure collections dedicated to drug repurposing and fragment-based drug design.

Published in:

Bioinformatics, 2012, v. 28, n. 11, p. 1540, doi. 10.1093/bioinformatics/bts186

By:

Pihan, Emilie;
Colliandre, Lionel;
Guichou, Jean-François;
Douguet, Dominique

Publication type:

Article

361. SAR DIFFERENCES FOR A SERIES OF N- AND C(4)SUBSTITUTED-TETRAHYDROPYRIDINES AND -PYRIDINIUM ANALOGS OF THE NIGROSTRIATAL NEUROTOXIN MPTP AS CYTOCHROME P450 2D6 SUBSTRATE AND INHIBITORS.

Published in:: 2002
Publication type:: Abstract

FRONTIER ORBITALS IN CHEMICAL AND BIOLOGICAL ACTIVITY: QUANTITATIVE RELATIONSHIPS AND MECHANISTIC IMPLICATIONS*.

Published in:

Drug Metabolism Reviews, 1999, v. 31, n. 3, p. 755, doi. 10.1081/DMR-100101943

By:

LEWIS, DAVID F. V.

Publication type:

Article

Structure-Activity Relationship of Terpenes with Anti-Inflammatory Profile - A Systematic Review.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2014, v. 115, n. 3, p. 244, doi. 10.1111/bcpt.12221

By:

Santana Souza, Marilia Trindade;
Almeida, Jackson Roberto Guedes da Silva;
Souza Araujo, Adriano Antunes;
Duarte, Marcelo Cavalcante;
Gelain, Daniel Pens;
Moreira, José Cláudio Fonseca;
Santos, Marcio Roberto Viana;
Quintans‐Júnior, Lucindo José

Publication type:

Article

Cytotoxicity and Structure-activity Relationships of Naphthyridine Derivatives in Human Cervical Cancer, Leukemia, and Prostate Cancer.

Published in:

Korean Journal of Physiology & Pharmacology, 2013, v. 17, n. 6, p. 517, doi. 10.4196/kjpp.2013.17.6.517

By:

Yu Jin Hwang;
Mi Lyang Chung;
Uy Dong Sohn;
Chaeuk Im

Publication type:

Article

Structure-activity relationships study of mTOR kinase inhibition using QSAR and structure-based drug design approaches.

Published in:

OncoTargets & Therapy, 2016, v. 9, p. 7345, doi. 10.2147/OTT.S108526

By:

Lakhlili, Wiame;
Yasri, Abdelaziz;
Ibrahimi, Azeddine

Publication type:

Article

Probing the chemical-biological relationship space with the Drug Target Explorer.

Published in:

Journal of Cheminformatics, 2018, v. 10, n. 1, p. 1, doi. 10.1186/s13321-018-0297-4

By:

Allaway, Robert J.;
La Rosa, Salvatore;
Guinney, Justin;
Gosline, Sara J. C.

Publication type:

Article

Generation of artificial neural networks models in anticancer study.

Published in:

Neural Computing & Applications, 2013, v. 23, n. 3/4, p. 577, doi. 10.1007/s00521-013-1404-0

By:

Sousa, Inês;
Padrón, José;
Fernandes, Miguel

Publication type:

Article

Anticancer Activity Evaluation of New Thieno[2,3-d]pyrimidin-4(3H)-ones and Thieno[3,2-d]pyrimidin-4(3H)-one Derivatives.

Published in:

Scientia Pharmaceutica, 2018, v. 86, n. 3, p. 1, doi. 10.3390/scipharm86030028

By:

Shyyka, Olga;
Pokhodylo, Nazariy;
Finiuk, Nataliya;
Matiychuk, Vasyl;
Stoika, Rostyslav;
Obushak, Mykola

Publication type:

Article

Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors.

Published in:

Scientia Pharmaceutica, 2016, v. 84, n. 3, p. 428, doi. 10.3390/scipharm84030428

By:

Elhady, Ahmed K.;
Sigler, Sara C.;
Noureldin, Nazih;
Canzoneri, Joshua C.;
Ahmed, Nermin S.;
Piazza, Gary A.;
Abadi, Ashraf H.

Publication type:

Article

The Study of Structure—Analgesic Activity Relationships in a Series of 4-Hydroxy-2,2-dioxo-1H- 2λ<sup>6</sup>,1-benzothiazine-3-carboxylic Acid Toluidides and Xylidides.

Published in:

Scientia Pharmaceutica, 2016, v. 84, n. 3, p. 497, doi. 10.3390/scipharm84030497

By:

Ukrainets, Igor V.;
Petrushova, Lidiya A.;
Sidorenko, Lyudmila V.;
Davidenko, Alexandra A.;
Duchenko, Marina A.

Publication type:

Article

Synthesis, Structural Elucidation, and In Vitro Antitumor Activities of Some Pyrazolopyrimidines and Schiff Bases Derived from 5-Amino-3-(arylamino)-1H-pyrazole-4-carboxamides.

Published in:

Scientia Pharmaceutica, 2013, v. 81, n. 2, p. 339, doi. 10.3797/scipharm.1211-07

By:

HAFEZ, Taghrid S.;
OSMAN, Souad A.;
YOSEF, Hisham Abdallah A.;
Abd EL-ALL, Amira S.;
HASSAN, Ashraf S.;
EL-SAWY, Abdallah A.;
ABDALLAH, Mohamed M.;
YOUNS, Mahmoud

Publication type:

Article

QSAR study on quinolinecarbaldehyde derivatives as potential anti-tubercular agents.

Published in:

Thai Journal of Pharmaceutical Sciences, 2016, v. 40, n. 2, p. 72

By:

Veerasamy, Ravichandran;
Sivadasan, Shalini;
Krishnamoorthi, Venakteskumar;
Rajak, Harish;
Krishnan, Sureshkumar

Publication type:

Article

A-Ring-Modified 2-Hydroxyethylidene Previtamin D<sub>3</sub> Analogues: Synthesis and Biological Evaluation.

Published in:

European Journal of Organic Chemistry, 2017, v. 2017, n. 3, p. 504, doi. 10.1002/ejoc.201601263

By:

Hernández‐Martín, Alba;
Fernández, Susana;
Verstuyf, Annemieke;
Verlinden, Lieve;
Ferrero, Miguel

Publication type:

Article

Aktywność in vitro worikonazolu i kaspofunginy wobec szczepów Candida spp. oceniana metodą Etestu.

Published in:

Medical Mycology / Mikologia, 2008, v. 15, n. 1, p. 13

By:

Szymankiewicz, Maria;
Dancewicz, Maciej

Publication type:

Article

Imidazolium salts with antifungal potential against multidrug-resistant dermatophytes.

Published in:

Journal of Applied Microbiology, 2015, v. 119, n. 2, p. 377, doi. 10.1111/jam.12862

By:

Dalla Lana, D.F.;
Donato, R.K.;
Bündchen, C.;
Guez, C.M.;
Bergamo, V.Z.;
Oliveira, L.F.S.;
Machado, M.M.;
Schrekker, H.S.;
Fuentefria, A.M.

Publication type:

Article

Tandem Favorskii Intermediate/Cyclization Leading to Tricyclo[4.4.0.0]decanediones.

Published in:

Synthetic Communications, 2006, v. 36, n. 7, p. 929, doi. 10.1080/00397910500466207

By:

Karimi, Sasan;
Christodoulou, Julia;
Subramaniam, Gopal

Publication type:

Article

Structure-activity relationship of a series of 17 parabens and related compounds for histamine release in rat peritoneal mast cells and skin allergic reaction in guinea pigs.

Published in:

Journal of Toxicological Sciences, 2014, v. 39, n. 1, p. 83, doi. 10.2131/jts.39.83

By:

Naoto Uramaru;
Toshio Inoue;
Yoko Watanabe;
Hidenari Shigematsu;
Shigeru Ohta;
Shigeyuki Kitamura

Publication type:

Article

A delicate mix.

Published in:

Physician & Sportsmedicine, 1996, v. 24, n. 5, p. 29, doi. 10.3810/psm.1996.05.1364

By:

Kleiner, Susan M.

Publication type:

Article

Food and pharmacology.

Published in:: Physician & Sportsmedicine, 1996, v. 24, n. 5, p. 30
Publication type:: Article

Development of Phenyl Cyclohexylcarboxamides as a Novel Class of Hsp90 C-terminal Inhibitors.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 65, p. 16574, doi. 10.1002/chem.201703206

By:

Garg, Gaurav;
Forsberg, Leah K.;
Zhao, Huiping;
Blagg, Brian S. J.

Publication type:

Article

Intramolecular Diaza-Diels-Alder Protocol: A New Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 17, p. 4137, doi. 10.1002/chem.201605231

By:

Srinivasulu, Vunnam;
Reddy, Amarnath;
Mazitschek, Ralph;
Lukens, Amanda K.;
Wirth, Dyann F.;
Li, Liang;
Naumov, Panče;
O'Connor, Matthew John;
Al‐Tel, Taleb H.

Publication type:

Article

Complete regression and systemic protective immune responses obtained in B16 melanomas after treatment with LTX-315.

Published in:

Cancer Immunology, Immunotherapy, 2014, v. 63, n. 6, p. 601, doi. 10.1007/s00262-014-1540-0

By:

Camilio, Ketil;
Berge, Gerd;
Ravuri, Chandra;
Rekdal, Øystein;
Sveinbjørnsson, Baldur

Publication type:

Article

Synthesis and in vitro cytotoxic activity of novel pyrazolo[1,5-a]pyrimidines and related Schiff bases.

Published in:

Turkish Journal of Chemistry, 2015, v. 39, n. 5, p. 1102, doi. 10.3906/kim-1504-12

By:

HASSAN, Ashraf Sayed;
HAFEZ, Taghrid Shoukry;
OSMAN, Souad Abdel Meguid;
ALI, Mamdouh Moawad

Publication type:

Article

Synthesis and evaluation of enzyme inhibitory potential of some derivatives of scopolamine.

Published in:

Turkish Journal of Chemistry, 2012, v. 36, n. 2, p. 257, doi. 10.3906/kim-1108-59

By:

Shahwar, Durre;
Raza, Muhammad Asam;
Khan, Tania

Publication type:

Article

Synthesis, Characterization, Antidepressant Activity and Docking Studies of Some Novel Indole Bearing Azetidinone Derivatives.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2018, v. 52, n. 1, p. 110, doi. 10.5530/ijper.52.1.13

By:

Kerzare, Deweshri Rajendrakumar;
Menghani, Sunil Sugnomal;
Khedekar, Pramod Bhujangrao

Publication type:

Article

新型帕唑帕尼衍生物的合成与活性初步研究.

Published in:

Journal of Central China Normal University, 2017, v. 51, n. 6, p. 782, doi. 10.19603/j.cnki.1000-1190.2017.06.010

By:

刘娥;
李立威

Publication type:

Article

Development of a Dynamic Physiologically Based Mechanistic Kidney Model to Predict Renal Clearance.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 9, p. 593, doi. 10.1002/psp4.12321

By:

Huang, Weize;
Isoherranen, Nina

Publication type:

Article

NMR and protein structure in drug design: application to cyclotides and conotoxins.

Published in:

European Biophysics Journal, 2011, v. 40, n. 4, p. 359, doi. 10.1007/s00249-011-0672-9

By:

Daly, Norelle;
Rosengren, K.;
Troeira Henriques, Sónia;
Craik, David

Publication type:

Article

Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond.

Published in:

IUBMB Life, 2014, v. 66, n. 12, p. 803, doi. 10.1002/iub.1334

By:

Xu, Shu;
Rouzer, Carol A.;
Marnett, Lawrence J.

Publication type:

Article

Insect Antimicrobial Peptides, a Mini Review.

Published in:

Toxins, 2018, v. 10, n. 11, p. 461, doi. 10.3390/toxins10110461

By:

Wu, Qinghua;
Patočka, Jiří;
Kuča, Kamil

Publication type:

Article

3D QSAR Studies on Some 5-(1H-Indol-5-yl)-1, 3, 4-Thiadiazol-2 Amines as Potential PIM-1 Inhibitors.

Published in:

Journal of Young Pharmacists, 2017, v. 9, n. 2, p. 162, doi. 10.5530/jyp.2017.9.32

By:

Kumar, Panche Tulesh;
Piyush, Ghode;
Kumar, Jain Sanmati

Publication type:

Article

Synthesis and Antimicrobial Activity of 2-[2-(2,6-dichloro phenyl)amino]benzyl-3-(5-substituted phenyl-4,5-dihydro-1H-pyrazol-3-yl-amino)-6,8-dibromoquinazolin-4(3H)ones.

Published in:

Journal of Young Pharmacists, 2010, v. 2, n. 2, p. 173, doi. 10.4103/0975-1483.63165

By:

Navin B. Patel;
Patel, J. C.;
Barat, G. G.

Publication type:

Article

A computational method to facilitate structure-activity relationship transfer.

Published in:

2012

By:

Wassermann, Anne Mai;
Bajorath, Jürgen

Publication type:

Abstract

Structure-Activity Relationships of Haemolytic Saponins.

Published in:

Pharmaceutical Biology, 2002, v. 40, n. 4, p. 253, doi. 10.1076/phbi.40.4.253.8470

By:

Voutquenne, Laurence;
Lavaud, Catherine;
Massiot, Georges;
Le Men-Olivier, Louisette

Publication type:

Article

Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0129807

By:

Xiao, Min;
Wang, Jin;
Lin, Zongtao;
Lu, Yan;
Li, Zhenmei;
White, Stephen W.;
Miller, Duane D.;
Li, Wei

Publication type:

Article

Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0124210

By:

Abraham, Parvin;
Sundaram, Anand;
R, Asha;
V, Reshmy;
George, Sanil;
Kumar, K. Santhosh

Publication type:

Article

Rational Design, Synthesis, and Biological Evaluation of Third Generation α-Noscapine Analogues as Potent Tubulin Binding Anti-Cancer Agents.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0077970

By:

Manchukonda, Naresh Kumar;
Naik, Pradeep Kumar;
Santoshi, Seneha;
Lopus, Manu;
Joseph, Silja;
Sridhar, Balasubramanian;
Kantevari, Srinivas

Publication type:

Article

Tracking 20 Years of Compound-to-Target Output from Literature and Patents.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0077142

By:

Southan, Christopher;
Varkonyi, Peter;
Boppana, Kiran;
Jagarlapudi, Sarma A.R.P.;
Muresan, Sorel

Publication type:

Article

Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0069619

By:

Rickard, David J.;
Sehon, Clark A.;
Kasparcova, Viera;
Kallal, Lorena A.;
Zeng, Xin;
Montoute, Monica N.;
Chordia, Tushar;
Poore, Derek D.;
Li, Hu;
Wu, Zining;
Eidam, Patrick M.;
Haile, Pamela A.;
Yu, Jong;
Emery, John G.;
Marquis, Robert W.;
Gough, Peter J.;
Bertin, John

Publication type:

Article

Anti-Cancer Efficacy of Silybin Derivatives - A Structure-Activity Relationship.

Published in:

PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0060074

By:

Agarwal, Chapla;
Wadhwa, Ritambhara;
Deep, Gagan;
Biedermann, David;
Gažák, Radek;
Křen, Vladimír;
Agarwal, Rajesh

Publication type:

Article

The N-Terminal HSDCIF Motif Is Required for Cell Surface Trafficking and Dimerization of Family B G Protein Coupled Receptor PAC1.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0051811

By:

Rongjie Yu;
Xiaoling Guo;
Jiaping Zhong;
Mei Li;
Zhixing Zeng;
Huahua Zhang

Publication type:

Article

Synthesis and Antiangiogenic Activity of N-Alkylated Levamisole Derivatives.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0045405

By:

Hansen, Anders N.;
Bendiksen, Christine D.;
Sylvest, Lene;
Friis, Tina;
Staerk, Dan;
Jørgensen, Flemming Steen;
Olsen, Christian A.;
Houen, Gunnar;
Todd, Matthew H.

Publication type:

Article

Solvent Free Fabrication of Micro and Nanostructured Drug Coatings by Thermal Evaporation for Controlled Release and Increased Effects.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0040746

By:

Zarie, Eman S.;
Kaidas, Viktor;
Gedamu, Dawit;
Mishra, Yogendra K.;
Adelung, Rainer;
Furkert, Franz H.;
Scherließ, Regina;
Steckel, Hartwig;
Groessner-Schreiber, Birte;
Bansal, Vipul

Publication type:

Article