Coagulation disorders in pregnancy: acquired and inherited thrombophilias.

Benedetto, Chiara; Marozio, Luca; Tavella, Anna Maria; Salton, Loredana; Grivon, Sara; Di Giampaolo, Francesca

Both acquired and inherited thrombophilias are associated with an increased risk of pregnancy-related venous thromboembolism (VTE) as well as with adverse pregnancy outcome. However, the extension of attributable risk for each thrombophilia and outcome is still a question of debate. Thrombophilias have been investigated in connection with VTE and pregnancy complications such as: recurrent and nonrecurrent early pregnancy loss, late fetal death, placental abruption, fetal growth restriction, and preeclampsia. This review discusses the evidence of association between thrombophilias and pregnancy outcome together with issues as to clinical management and preventive strategies.

BLOOD coagulation disorders in pregnancy; THROMBOSIS; PREGNANCY complications; FETAL death; PREECLAMPSIA

Annals of the New York Academy of Sciences, 2010, Vol 1205, Issue 1, p106

0077-8923

Academic Journal

10.1111/j.1749-6632.2010.05674.x