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Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis.
- Published in:
- Pharmacology Research & Perspectives, 2019, v. 7, n. 4, p. N.PAG, doi. 10.1002/prp2.513
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- Publication type:
- Article
Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor.
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- Pharmacology Research & Perspectives, 2018, v. 6, n. 5, p. 1, doi. 10.1002/prp2.432
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- Publication type:
- Article
Synthetic short-chain peptide analogues of H1 relaxin lack affinity for the RXFP1 receptor and relaxin-like bioactivity. Clues to a better understanding of relaxin agonist design.
- Published in:
- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.942178
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- Publication type:
- Article
The Structural and Functional Role of the B-chain C-terminal Arginine in the Relaxin-3 Peptide Antagonist, R3(BΔ23-27)R/I5.
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- Chemical Biology & Drug Design, 2009, v. 73, n. 1, p. 46, doi. 10.1111/j.1747-0285.2008.00756.x
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- Publication type:
- Article
A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6616, doi. 10.3390/ijms24076616
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- Publication type:
- Article
A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1908, doi. 10.3390/ijms23031908
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- Publication type:
- Article
Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis.
- Published in:
- Kidney International, 2014, v. 86, n. 1, p. 75, doi. 10.1038/ki.2013.518
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- Publication type:
- Article
Reversal of Cardiac Fibrosis and Related Dysfunction by Relaxin.
- Published in:
- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 278, doi. 10.1111/j.1749-6632.2008.03780.x
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- Publication type:
- Article
Probing the Functional Domains of Relaxin-3 and the Creation of a Selective Antagonist for RXFP3/GPCR135 over Relaxin Receptor RXFP1/LGR7.
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- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 31, doi. 10.1111/j.1749-6632.2008.03790.x
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- Publication type:
- Article
Structural Properties of Relaxin Chimeras.
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- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 27, doi. 10.1111/j.1749-6632.2008.03805.x
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- Publication type:
- Article
RXFP1 Couples to the Gα<sub>i3</sub>-Gβγ-PI3K-PKCζ Pathway via the Final 10 Amino Acids of the Receptor C-terminal Tail.
- Published in:
- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 117, doi. 10.1111/j.1749-6632.2008.03813.x
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- Publication type:
- Article
Relaxin Activates Multiple cAMP Signaling Pathway Profiles in Different Target Cells.
- Published in:
- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 108, doi. 10.1111/j.1749-6632.2008.03814.x
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- Publication type:
- Article
Development and Optimization of MicroRNA against Relaxin-3.
- Published in:
- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 261, doi. 10.1111/j.1749-6632.2008.03816.x
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- Publication type:
- Article
Activation of Relaxin-Related Receptors by Short, Linear Peptides Derived from a Collagen-Containing Precursor.
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- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 78, doi. 10.1111/j.1749-6632.2009.03827.x
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- Publication type:
- Article
Investigations into the Inhibitory Effects of Relaxin on Renal Myofibroblast Differentiation.
- Published in:
- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 294, doi. 10.1111/j.1749-6632.2008.03823.x
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- Publication type:
- Article
Roles of the Receptor, the Ligand, and the Cell in the Signal Transduction Pathways Utilized by the Relaxin Family Peptide Receptors 1–3.
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- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 99, doi. 10.1111/j.1749-6632.2009.03828.x
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- Publication type:
- Article
Structural Insights into the Function of Relaxins.
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- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 20, doi. 10.1111/j.1749-6632.2009.03833.x
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- Publication type:
- Article
De Novo Design and Synthesis of Cyclic and Linear Peptides to Mimic the Binding Cassette of Human Relaxin.
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- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 16, doi. 10.1111/j.1749-6632.2009.03840.x
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- Publication type:
- Article
Dimerization and Negative Cooperativity in the Relaxin Family Peptide Receptors.
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- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 54, doi. 10.1111/j.1749-6632.2009.03835.x
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- Publication type:
- Article
Development of Lanthanide-Labeled Human INSL3 as an Alternative Probe to Radioactively Labeled INSL3 for Use in Bioassays.
- Published in:
- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 87, doi. 10.1111/j.1749-6632.2009.03839.x
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- Publication type:
- Article
Resolving the Unconventional Mechanisms Underlying RXFP1 and RXFP2 Receptor Function.
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- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 67, doi. 10.1111/j.1749-6632.2009.03949.x
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- Publication type:
- Article
Modeling the Primary Hormone-Binding Site of RXFP1 and RXFP2.
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- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 74, doi. 10.1111/j.1749-6632.2009.03950.x
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- Publication type:
- Article
Structure and Activity in the Relaxin Family of Peptides.
- Published in:
- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 5, doi. 10.1111/j.1749-6632.2009.03955.x
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- Publication type:
- Article
Relaxin Family Peptides and Receptors in Mammalian Brain.
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- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 226, doi. 10.1111/j.1749-6632.2009.03956.x
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- Publication type:
- Article
Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-44010-7
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- Publication type:
- Article
C-Terminus of the B-Chain of Relaxin-3 Is Important for Receptor Activity.
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- PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0082567
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- Publication type:
- Article
Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMPDependent Pathway to Up- Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS.
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- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042714
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- Publication type:
- Article
Silencing Relaxin-3 in Nucleus Incertus of Adult Rodents: A Viral Vector- based Approach to Investigate Neuropeptide Function.
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- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042300
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- Publication type:
- Article
Promise and Limitations of Relaxin-based Therapies in Chronic Fibrotic Lung Diseases.
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- 2016
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- Publication type:
- journal article
Responses of GPCR135 to Human Gene 3 (H3) Relaxin in CHO-K1 Cells Determined by Microphysiometry.
- Published in:
- Annals of the New York Academy of Sciences, 2005, v. 1041, n. 1, p. 332, doi. 10.1196/annals.1282.053
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- Publication type:
- Article
Localization of LGR7 Gene Expression in Adult Mouse Brain Using LGR7 Knock-out/LacZ Knock-in Mice: Correlation with LGR7 mRNA Distribution.
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- Annals of the New York Academy of Sciences, 2005, v. 1041, n. 1, p. 197, doi. 10.1196/annals.1282.030
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- Publication type:
- Article
Design and recombinant expression of insulin-like peptide 5 precursors and the preparation of mature human INSL5.
- Published in:
- Amino Acids, 2010, v. 39, n. 5, p. 1343, doi. 10.1007/s00726-010-0586-3
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- Publication type:
- Article
The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist.
- Published in:
- Amino Acids, 2010, v. 39, n. 2, p. 409, doi. 10.1007/s00726-009-0454-1
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- Publication type:
- Article
Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3.
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- Amino Acids, 2010, v. 38, n. 1, p. 121, doi. 10.1007/s00726-008-0219-2
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- Publication type:
- Article
Design, synthesis and pharmacological evaluation of cyclic mimetics of the insulin-like peptide 3 (INSL3) B-chain.
- Published in:
- Journal of Peptide Science, 2007, v. 13, n. 2, p. 113, doi. 10.1002/psc.807
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- Publication type:
- Article
Synthetic human insulin 4 does not activate the G-protein-coupled receptors LGR7 or LGR8.
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- Journal of Peptide Science, 2004, v. 10, n. 5, p. 257, doi. 10.1002/psc.521
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- Publication type:
- Article
Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin.
- Published in:
- Bioscience Reports, 2023, v. 43, n. 4, p. 1, doi. 10.1042/BSR20221956
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- Publication type:
- Article
Biallelic RXFP2 variants lead to congenital bilateral cryptorchidism and male infertility, supporting a role of RXFP2 in spermatogenesis.
- Published in:
- Human Reproduction, 2024, v. 39, n. 10, p. 2353, doi. 10.1093/humrep/deae195
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- Publication type:
- Article
Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility.
- Published in:
- Human Reproduction, 2023, v. 38, n. 7, p. 1412, doi. 10.1093/humrep/dead105
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- Publication type:
- Article
Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-53707-z
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- Publication type:
- Article
The anti‐fibrotic actions of relaxin are mediated through AT<sub>2</sub>R‐associated protein phosphatases via RXFP1‐AT<sub>2</sub>R functional crosstalk in human cardiac myofibroblasts.
- Published in:
- FASEB Journal, 2020, v. 34, n. 6, p. 8217, doi. 10.1096/fj.201902506R
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- Publication type:
- Article
Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2.
- Published in:
- FASEB Journal, 2009, v. 23, n. 4, p. 1219, doi. 10.1096/fj.08-120857
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- Publication type:
- Article
Recombinant expression of an insulin-like peptide 3 (INSL3) precursor and its enzymatic conversion to mature human INSL3.
- Published in:
- FEBS Journal, 2009, v. 276, n. 18, p. 5203, doi. 10.1111/j.1742-4658.2009.07216.x
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- Publication type:
- Article
Relaxin-2 Does Not Ameliorate Nephropathy in an Experimental Model of Type-1 Diabetes.
- Published in:
- Kidney & Blood Pressure Research, 2015, v. 40, n. 1, p. 77, doi. 10.1159/000368484
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- Publication type:
- Article
The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1.
- Published in:
- Nature Communications, 2016, v. 7, n. 4, p. 11344, doi. 10.1038/ncomms11344
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- Publication type:
- Article
Molecular Profiling of VGluT1 AND VGluT2 Ventral Subiculum to Nucleus Accumbens Shell Projections.
- Published in:
- Neurochemical Research, 2023, v. 48, n. 8, p. 2490, doi. 10.1007/s11064-023-03921-z
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- Publication type:
- Article
Selective transduction and photoinhibition of pre-Bötzinger complex neurons that project to the facial nucleus in rats affects nasofacial activity.
- Published in:
- eLife, 2023, p. 1, doi. 10.7554/eLife.85398
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- Publication type:
- Article
Colokinetic effect of an insulin‐like peptide 5‐related agonist of the RXFP4 receptor.
- Published in:
- Neurogastroenterology & Motility, 2020, v. 32, n. 5, p. 1, doi. 10.1111/nmo.13796
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- Publication type:
- Article
Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor.
- Published in:
- 2017
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- Publication type:
- journal article
Relaxin family peptides: structure-activity relationship studies.
- Published in:
- 2017
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- Publication type:
- journal article