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Title

Drotrecogin alfa: A role in emergency department treatment of severe sepsis?

Authors

McLeay, Adam M.

Abstract

Human protein C is a serine protease that circulates in the blood as an inactive zymogen. It is converted to its active form by interaction with thrombomodulin on the endothelial wall. Activated protein C has a significant role in maintaining haemostasis, and is a major mechanism of controlling microvascular thrombosis. Recent reports describe the use of drotrecogin alfa (recombinant activated protein C) in severe sepsis, a condition relevant to emergency medicine. This review describes the physiology of the protein C pathway and its importance in sepsis. It will also focus on the use of drotrecogin alfa in sepsis, and its use in the ED.

Subjects

PROTEIN C; SERINE proteinases; THROMBOMODULIN; HEMOSTASIS; THROMBOSIS; RECOMBINANT proteins

Publication

Emergency Medicine Australasia, 2004, Vol 16, Issue 4, p324

ISSN

1742-6731

Publication type

Academic Journal

DOI

10.1111/j.1742-6723.2004.00630.x

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