Magnification angiography was used to visualize the mandibular vasculature of beagle doss with either minimal or moderate to severe periodontal disease. The arteriograms were qualitatively graded with respect to numbers of vessels and vessel architecture. Arteriograms of the dogs with moderate to severe periodontal disease revealed a significant increase in vessel density and tortuosity when compared to dogs with minimal disease. The technique presented in this report provides a non-destructive method for the in vivo study of the vascular architecture in periodontal disease.