Works matching DE "PROGERIA"

Results: 429

Baricitinib and Lonafarnib Synergistically Target Progerin and Inflammation, Improving Lifespan and Health in Progeria Mice.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4849, doi. 10.3390/ijms26104849

By:

Krüger, Peter;
Schroll, Moritz;
Fenzl, Felix Quirin;
Hartinger, Ramona;
Lederer, Eva-Maria;
Görlach, Agnes;
Gordon, Leslie B.;
Cavalcante, Paola;
Iacomino, Nicola;
Rathkolb, Birgit;
Pimentel, Juan Antonio Aguilar;
Östereicher, Manuela;
Spielmann, Nadine;
Wolf, Cordula Maria;
de Angelis, Martin Hrabe;
Djabali, Karima

Publication type:

Article

Crystal structure of progeria mutant S143F lamin A/C reveals increased hydrophobicity driving nuclear deformation.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03212-3

By:

Ahn, Jinsook;
Jeong, Soyeon;
Kang, So-mi;
Jo, Inseong;
Park, Bum-Joon;
Ha, Nam-Chul

Publication type:

Article

Multisystem Progeroid Syndrome With Lipodystrophy, Cardiomyopathy, and Nephropathy Due to an LMNA p.R349W Variant.

Published in:

Journal of the Endocrine Society, 2020, v. 4, n. 10, p. 1, doi. 10.1210/jendso/bvaa104

By:

Hussain, Iram;
Jin, Ruilin Raelene;
Baum, Howard B A;
Greenfield, Jerry R;
Devery, Sophie;
Xing, Chao;
Hegele, Robert A;
Carranza-Leon, Barbara G;
Linton, Macrae F;
Vuitch, Frank;
Wu, Kathy H C;
Precioso, Débora Rossi;
Oshima, Junko;
Agarwal, Anil K;
Garg, Abhimanyu

Publication type:

Article

Status of treatment strategies for Hutchinson–Gilford progeria syndrome with a focus on prelamin: A posttranslational modification.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2022, v. 131, n. 4, p. 217, doi. 10.1111/bcpt.13770

By:

Chen, Xue;
Yao, Haidong;
Andrés, Vicente;
Bergo, Martin O.;
Kashif, Muhammad

Publication type:

Article

ELASTIC FIBRES IN UNUSUAL DERMATOSES.

Published in:

British Journal of Dermatology, 1955, v. 67, n. 12, p. 460

By:

J. K.

Publication type:

Article

WERNER'S SYNDROME.

Published in:

British Journal of Dermatology, 1953, v. 65, n. 5, p. 165, doi. 10.1111/j.1365-2133.1953.tb13193.x

By:

Reed, R.;
Seville, R. H.;
Tattersall, R. N.

Publication type:

Article

Immunological studies on Werner's syndrome.

Published in:

Clinical & Experimental Immunology, 1980, v. 42, n. 1, p. 10

By:

Nakao, Y.;
Hattori, T.;
Takatsuki, K.;
Kuroda, Y.;
Nakaji, T.;
Fujiwara, Y.;
Kishihara, M.;
Baba, Y.;
Fujita, T.

Publication type:

Article

Athena: Speciality Certificate Examination case for Paediatrics and Genetics.

Published in:

Clinical & Experimental Dermatology, 2022, v. 47, n. 8, p. 1595, doi. 10.1111/ced.14707

By:

Sharma, S.;
Bhalla, K.;
Dayal, S.

Publication type:

Article

A brother and sister with Werner's syndrome demonstrating extensive tendon calcification and sacroiliitis.

Published in:

Clinical & Experimental Dermatology, 2006, v. 31, n. 4, p. 615, doi. 10.1111/j.1365-2230.2006.02130.x

By:

Özturk, M.;
Akdeniz, N.;
Ayakta^1, H.;
Kösem, M.

Publication type:

Article

Tight skin and limited joint movements as early presentation of Hutchinson-Gilford progeria in a 7-week-old infant.

Published in:

2005

By:

Sevenants, Lieve;
Wouters, Carine;
Sandre-Giovannoli, Annachiara;
Devlieger, Hugo;
Devriendt, Koen;
Oord, Joost;
Marien, Karel;
Lévy, Nicolas;
Morren, Marie-Anne;
De Sandre-Giovannoli, Annachiara;
van den Oord, Joost J;
Lévy, Nicolas

Publication type:

journal article

Correction to: Lonafarnib: First Approval.

Published in:

Drugs, 2021, v. 81, n. 5, p. 619, doi. 10.1007/s40265-021-01500-6

By:

Dhillon, Sohita

Publication type:

Article

Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients.

Published in:

Aging & Disease, 2020, v. 11, n. 3, p. 536, doi. 10.14336/AD.2019.0610

By:

Tiemann, Janina;
Wagner, Thomas;
Vanakker, Olivier M.;
van Gils, Matthias;
Bueno Cabrera, José-Luis;
Ibold, Bettina;
Faust, Isabel;
Knabbe, Cornelius;
Hendig, Doris

Publication type:

Article

Nuclear Abnormalities in LMNA p.(Glu2Lys) Variant Segregating with LMNA -Associated Cardiocutaneous Progeria Syndrome.

Published in:

Genes, 2024, v. 15, n. 1, p. 112, doi. 10.3390/genes15010112

By:

Wilke, Matheus V. M. B.;
Wick, Myra;
Schwab, Tanya L.;
Starosta, Rodrigo Tzovenos;
Clark, Karl J.;
Connolly, Heidi M.;
Klee, Eric W.

Publication type:

Article

The Molecular and Cellular Basis of Hutchinson–Gilford Progeria Syndrome and Potential Treatments.

Published in:

Genes, 2023, v. 14, n. 3, p. 602, doi. 10.3390/genes14030602

By:

Batista, Noelle J.;
Desai, Sanket G.;
Perez, Alexis M.;
Finkelstein, Alexa;
Radigan, Rachel;
Singh, Manrose;
Landman, Aaron;
Drittel, Brian;
Abramov, Daniella;
Ahsan, Mina;
Cornwell, Samantha;
Zhang, Dong

Publication type:

Article

Splicing Variants, Protein-Protein Interactions, and Drug Targeting in Hutchinson-Gilford Progeria Syndrome and Small Cell Lung Cancer.

Published in:

Genes, 2022, v. 13, n. 2, p. 165, doi. 10.3390/genes13020165

By:

Kim, Bae-Hoon;
Woo, Tae-Gyun;
Kang, So-Mi;
Park, Soyoung;
Park, Bum-Joon

Publication type:

Article

A Link between Replicative Stress, Lamin Proteins, and Inflammation.

Published in:

Genes, 2021, v. 12, n. 4, p. 552, doi. 10.3390/genes12040552

By:

Willaume, Simon;
Rass, Emilie;
Fontanilla-Ramirez, Paula;
Moussa, Angela;
Wanschoor, Paul;
Bertrand, Pascale

Publication type:

Article

Prelamin A and ZMPSTE24 in premature and physiological aging.

Published in:

Nucleus (1949-1034), 2023, v. 14, n. 1, p. 1, doi. 10.1080/19491034.2023.2270345

By:

Worman, Howard J.;
Michaelis, Susan

Publication type:

Article

Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells.

Published in:

Nucleus (1949-1034), 2020, v. 11, n. 1, p. 194, doi. 10.1080/19491034.2020.1802906

By:

Danielsson, Brooke E.;
Tieu, Katie V.;
Bathula, Kranthidhar;
Armiger, Travis J.;
Vellala, Pragna S.;
Taylor, Rebecca E.;
Dahl, Kris Noel;
Conway, Daniel E.

Publication type:

Article

Impairment of nuclear F-actin formation and its relevance to cellular phenotypes in Hutchinson-Gilford progeria syndrome.

Published in:

Nucleus (1949-1034), 2020, v. 11, n. 1, p. 250, doi. 10.1080/19491034.2020.1815395

By:

Takahashi, Yuto;
Hiratsuka, Shogo;
Machida, Nanako;
Takahashi, Daisuke;
Matsushita, Junpei;
Hozak, Pavel;
Misteli, Tom;
Miyamoto, Kei;
Harata, Masahiko

Publication type:

Article

Vascular smooth muscle cell loss underpins the accelerated atherosclerosis in Hutchinson-Gilford progeria syndrome.

Published in:

Nucleus (1949-1034), 2019, v. 10, n. 1, p. 48, doi. 10.1080/19491034.2019.1589359

By:

Hamczyk, Magda R.;
Andrés, Vicente

Publication type:

Article

An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome.

Published in:

Nucleus (1949-1034), 2019, v. 10, p. 265, doi. 10.1080/19491034.2018.1460045

By:

Harhouri, Karim;
Frankel, Diane;
Bartoli, Catherine;
Roll, Patrice;
De Sandre-Giovannoli, Annachiara;
Lévy, Nicolas

Publication type:

Article

Genomic instability and DNA replication defects in progeroid syndromes.

Published in:

Nucleus (1949-1034), 2018, v. 9, n. 1, p. 368, doi. 10.1080/19491034.2018.1476793

By:

Burla, Romina;
La Torre, Mattia;
Merigliano, Chiara;
Vernì, Fiammetta;
Saggio, Isabella

Publication type:

Article

Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells.

Published in:

Nucleus (1949-1034), 2018, v. 9, n. 1, p. 235, doi. 10.1080/19491034.2018.1460185

By:

Cho, Sangkyun;
Abbas, Amal;
Irianto, Jerome;
Ivanovska, Irena L.;
Xia, Yuntao;
Tewari, Manu;
Discher, Dennis E.

Publication type:

Article

An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome.

Published in:

Nucleus (1949-1034), 2018, v. 9, n. 1, p. 265, doi. 10.1080/19491034.2018.1460045

By:

Harhouri, Karim;
Frankel, Diane;
Bartoli, Catherine;
Roll, Patrice;
De Sandre-Giovannoli, Annachiara;
Lévy, Nicolas

Publication type:

Article

Identification of novel RNA isoforms of LMNA.

Published in:

Nucleus (1949-1034), 2017, v. 8, n. 5, p. 573, doi. 10.1080/19491034.2017.1348449

By:

DeBoy, Emily;
Puttaraju, Madaiah;
Jailwala, Parthav;
Kasoji, Manjula;
Cam, Maggie;
Misteli, Tom

Publication type:

Article

Lamin A and microtubules collaborate to maintain nuclear morphology.

Published in:

Nucleus (1949-1034), 2017, v. 8, n. 4, p. 433, doi. 10.1080/19491034.2017.1320460

By:

Tariq, Zeshan;
Zhang, Haoyue;
Chia-Liu, Alexander;
Shen, Yang;
Gete, Yantenew;
Xiong, Zheng-Mei;
Tocheny, Claire;
Campanello, Leonard;
Wu, Di;
Losert, Wolfgang;
Cao, Kan

Publication type:

Article

The nuclear lamina in health and disease.

Published in:

Nucleus (1949-1034), 2016, v. 7, n. 3, p. 233, doi. 10.1080/19491034.2016.1183848

By:

Dobrzynska, Agnieszka;
Gonzalo, Susana;
Shanahan, Catherine;
Askjaer, Peter

Publication type:

Article

Mammalian telomeres and their partnership with lamins.

Published in:

Nucleus (1949-1034), 2016, v. 7, n. 2, p. 187, doi. 10.1080/19491034.2016.1179409

By:

Burla, Romina;
La Torre, Mattia;
Saggio, Isabella

Publication type:

Article

Corrigendum.

Published in:: 2015
Publication type:: Correction Notice

Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells.

Published in:

Nucleus (1949-1034), 2015, v. 6, n. 1, p. 66, doi. 10.1080/19491034.2015.1004256

By:

Bercht Pfleghaar, Katrin;
Taimen, Pekka;
Butin-Israeli, Veronika;
Shimi, Takeshi;
Langer-Freitag, Sabine;
Markaki, Yolanda;
Goldman, Anne E;
Wehnert, Manfred;
Goldman, Robert D

Publication type:

Article

Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting.

Published in:

Nucleus (1949-1034), 2014, v. 5, n. 1, p. 1, doi. 10.4161/nucl.28068

By:

Wu, Di;
Flannery, Andrew R;
Cai, Helen;
Ko, Eunae;
Cao, Kan

Publication type:

Article

The contrasting roles of lamin B1 in cellular aging and human disease.

Published in:

Nucleus (1949-1034), 2013, v. 4, n. 4, p. 283, doi. 10.4161/nucl.25808

By:

Dreesen, Oliver;
Ong, Peh Fern;
Chojnowski, Alexandre;
Colman, Alan

Publication type:

Article

Reversal of laminopathies: the curious case of SUN1.

Published in:

Nucleus (1949-1034), 2012, v. 3, n. 5, p. 1, doi. 10.4161/nucl.21714

By:

Chi, Ya-hui;
Chen, Chia-yen;
Jeang, Kuan-Teh

Publication type:

Article

Progeria Research Day at Brunel University.

Published in:

Nucleus (1949-1034), 2011, v. 2, n. 6, p. 517, doi. 10.4161/nucl.2.6.17605

By:

Bridger, Joanna M.;
Eskiw, Christopher H.;
Makarov, Evgeny M.;
Tree, David;
Kill, Ian R.

Publication type:

Article

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.

Published in:

Nucleus (1949-1034), 2011, v. 2, n. 6, p. 1, doi. 10.4161/nucl.2.6.17798

By:

Choi, Siwon;
Wang, Wei;
Ribeiro, Alexandrew J.S.;
Kalinowski, Agnieszka;
Gregg, Siobhan Q.;
Opresko, Patricia L.;
Niedernhofer, Laura J.;
Rohde, Gustavo K.;
Dahl, Kris Noel

Publication type:

Article

Progerin Inhibits the Proliferation and Migration of Melanoma Cells by Regulating the Expression of Paxillin.

Published in:

OncoTargets & Therapy, 2024, v. 17, p. 227, doi. 10.2147/OTT.S442504

By:

Liu, Weixian;
Huang, Xinxian;
Luo, Weizhao;
Liu, Xinguang;
Chen, Weichun

Publication type:

Article

Overexpression of Progerin Results in Impaired Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 2629, doi. 10.2147/OTT.S237016

By:

Hu, Xiao-Ting;
Song, Hao-Chang;
Yu, Hui;
Wu, Zu-Chun;
Liu, Xin-Guang;
Chen, Wei-Chun

Publication type:

Article

Hutchinson–Gilford Progeria Syndrome: Clinical and Molecular Characterization.

Published in:

Application of Clinical Genetics, 2020, v. 13, p. 159, doi. 10.2147/TACG.S238715

By:

Pachajoa, Harry;
Claros-Hulbert, Angelica;
García-Quintero, Ximena;
Perafan, Lina;
Ramirez, Andres;
Zea-Vera, Andres F

Publication type:

Article

Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice.

Published in:

Journal of Anatomy, 2008, v. 213, n. 5, p. 509, doi. 10.1111/j.1469-7580.2008.00970.x

By:

de Carlos, F.;
Varela, I.;
Germanà, A.;
Montalbano, G.;
Freije, J. M. P.;
Vega, J. A.;
López-Otin, C.;
Cobo, J. M.

Publication type:

Article

Next-Generation Sequencing and Quantitative Proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging.

Published in:

PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0205878

By:

Mateos, Jesús;
Fafián-Labora, Juan;
Morente-López, Miriam;
Lesende-Rodriguez, Iván;
Monserrat, Lorenzo;
Ódena, María A.;
Oliveira, Eliandre de;
de Toro, Javier;
Arufe, María C.

Publication type:

Article

Hutchinson-Gilford progeria syndrome with severe calcific aortic valve stenosis.

Published in:

Annals of Pediatric Cardiology, 2011, v. 4, n. 2, p. 204, doi. 10.4103/0974-2069.84670

By:

Hanumanthappa, Natesh B.;
Madhusudan, Ganigara;
Mahimarangaiah, Jayaranganath;
Manjunath, Cholenahally N.

Publication type:

Article

Issue highlights.

Published in:

Acta Paediatrica, 2024, v. 113, n. 5, p. 848, doi. 10.1111/apa.17224

By:

Käll, Anna;
Lagercrantz, Hugo

Publication type:

Article

Hardened skin can be an early indicator of premature ageing: A case report of the progeria syndrome.

Published in:

Acta Paediatrica, 2024, v. 113, n. 5, p. 1112, doi. 10.1111/apa.17151

By:

Pasa Morgan, Mariana A.;
de Oliveira, Rafaela M.;
Gomes, Izabella R. R.;
Werner, Betina;
de Souza, Josiane;
Carvalho, Vânia O.

Publication type:

Article

Homozygous LMNA mutation R527C in atypical Hutchinson–Gilford progeria syndrome: evidence for autosomal recessive inheritance.

Published in:

Acta Paediatrica, 2009, v. 98, n. 8, p. 1365, doi. 10.1111/j.1651-2227.2009.01324.x

By:

Liang, Lili;
Zhang, Huiwen;
Gu, Xuefan

Publication type:

Article

Aging: A new target in progeria.

Published in:

Nature Medicine, 2013, v. 19, n. 6, p. 682, doi. 10.1038/nm.3243

By:

Swami, Meera

Publication type:

Article

Drug development for progeria yields insights into normal aging.

Published in:

Nature Medicine, 2013, v. 19, n. 5, p. 515, doi. 10.1038/nm0513-515b

By:

Jiang, Kevin

Publication type:

Article

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

Published in:

Nature Medicine, 2008, v. 14, n. 7, p. 767, doi. 10.1038/nm1786

By:

Varela, Ignacio;
Pereira, Sandrine;
Ugalde, Alejandro P.;
Navarro, Claire L.;
Suárez, María F.;
Cau, Pierre;
Cadiñanos, Juan;
Osorio, Fernando G.;
Foray, Nicolas;
Cobo, Juan;
De Carlos, Félix;
Lévy, Nicolas;
Freije, José M. P.;
López-Otín, Carlos

Publication type:

Article

Rejuvenating premature aging.

Published in:

Nature Medicine, 2008, v. 14, n. 7, p. 713, doi. 10.1038/nm0708-713

By:

Meshorer, Eran;
Gruenbaum, Yosef

Publication type:

Article

Research Highlights.

Published in:

Nature Medicine, 2006, v. 12, n. 3, p. 287, doi. 10.1038/nm0306-287

By:

C. S.;
E. C.;
J. B.

Publication type:

Article

Genome instability in progeria: when repair gets old.

Published in:

Nature Medicine, 2005, v. 11, n. 7, p. 718, doi. 10.1038/nm0705-718

By:

Misteli, Tom;
Scaffidi, Paola

Publication type:

Article