Therapeutic Effect of Dinitrochlorobenzene (DNCB) on Verruca Plana and Verruca Vulgaris.

Sungnack Lee; Chung Koo Cho; Joong Gie Kim; Soo Il Chun

Fifty-nine patients with verrucae (45 with verrucae plana and 14 with verrucae vulgaris) were treated with dinitrochlorobenzebe (DNCB) as a topical application on the normal uninvolved skin of the shoulder for sensitization and challenge. The patients were sensitized with 0.5 ml of 0.4% DNCB solution and then challenged with 0.1% DNCB ointment twice a week. Six cases of verrucae plana and 1 case of verrucae vulgaris were completely cured by sensitization only and 32 cases of verrucae plana and 7 cases of verrucae vulgaris were completely resolved by repeated challenges. The therapeutic effect was better in verrucae plana (84.4%) than in verrucae vulgaris (57.1%), and the verrucae were completely resolved within 10 weeks in more than 90% of the patients cured by challenge. The side effects of DCNB were mild allergic contact dermatitis and slight transitory hyperpigmentation at the site of application.

THERAPEUTICS; WARTS treatment; SKIN diseases; DERMATOLOGY; DIAGNOSIS

International Journal of Dermatology, 1984, Vol 23, Issue 9, p624

0011-9059

Academic Journal

10.1111/j.1365-4362.1984.tb05705.x