Title: DRUG PHOTOSENSITIZATION.
Authors: Jarratt, Michael
Abstract: The article presents information on drug photosensitization. Photosensitization of the skin by crude psoralen extracts from plants was recorded as early as 1400 B.C. Treatment of leukoderma with the psoralen-containing plant. Psoralea corylifolia appears in manuscripts from Eastern Turkistan, India, China and Egypt. Photosensitization of the skin may occur through pathways-phototoxicity and photoallergy. Phototoxic reactions are induced by photoactive drugs which absorb light energy and then contribute that energy to photo-chemical reactions which damage cellular DNA, cytoplasmic organelles or the cell membrane.
Subjects: DRUGS; PHYSIOLOGICAL effects of light; PSORALEA; LEGUMES; VITILIGO; DNA
Publication: International Journal of Dermatology, 1976, Vol 15, Issue 5, p317
ISSN: 0011-9059
Publication type: Academic Journal
DOI: 10.1111/j.1365-4362.1976.tb01801.x

DRUG PHOTOSENSITIZATION.

Jarratt, Michael