Effect of cypermethrin, carbendazim and their combination on male albino rat serum.

Veerappan, Muthuviveganandavel; Hwang, InHo; Pandurangan, Muthuraman

Alpha-cypermethrin and carbendazim are synthetic; α-cypermethrin belongs to a class of synthetic pyrethroids and carbendazim belongs to the class of carbamate fungicides. The current study was carried out to evaluate the low-dose exposure of individual and mixed forms of cypermethrin and carbendazim. α-cypermethrin was used at 0.06, 0.12, 0.30 and 0.60 mg/kg body weight (bw), carbendazim was at 0.48, 0.96, 2.4 and 4.8 mg/kg bw and combined doses (cypermethrin: 0.06, 0.12, 0.30 and 0.60 mg/kg.bwt carbendazim: 0.48, 0.96, 2.4 and 4.8 mg/kg.bwt) for 12 h and 24 h. The biochemical parameters and serum markey enzymes were analysed. The biochemical parameters include serum total protein, glucose, cholesterol, urea, uric acid, calcium, phosphorous, albumin and creatinine and serum marker enzymes such as alanine transaminase ( ALT), aspartate transaminase ( AST), alkaline phosphatase ( ALP), γ-glutamyl transpeptidase ( GGT) and amylase were ascertained. Results indicated simultaneous changes in serum marker enzyme activity ( ALT, AST, ALP, GGT and amylase) and biochemical markers (* P < 0.05, ** P < 0.01 and *** P < 0.001). The experimental results indicate that even low-dose use of the synthetic pyrethroid carbamate and their combined form results in consequential negative effects on cell function.

CYPERMETHRIN; CARBENDAZIM; LABORATORY rats; BLOOD serum analysis; BLOOD proteins; BIOMARKERS; ASPARTATE aminotransferase

International Journal of Experimental Pathology, 2012, Vol 93, Issue 5, p361

0959-9673

Academic Journal

10.1111/j.1365-2613.2012.00828.x