We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study.
- Authors
Kim, Tae Nyun; Park, Man Sik; Lim, Kang Il; Choi, Hae Yoon; Yang, Sae Jeong; Yoo, Hye Jin; Kang, Hyun Joo; Song, Wook; Choi, Hyuk; Baik, Sei Hyun; Choi, Dong Seop; Choi, Kyung Mook
- Abstract
Objective It has been suggested that insulin resistance, low-grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia. However, their relationships with sarcopenic obesity ( SO) are unclear. We evaluated the impact of homoeostasis model assessment of insulin resistance ( HOMA- IR), high-sensitivity C-reactive protein (hs CRP) and 25-hydroxyvitamin D (25[ OH] D) levels on SO in Korean adults. Study subject/measurements This study included 493 apparently healthy adults (180 men and 313 women) enrolled in the Korean Sarcopenic Obesity Study. Sarcopenia was defined as a skeletal muscle mass index ( SMI) of 1 SD below the sex-specific mean value for a young reference group. Obesity was defined as a visceral fat area ( VFA) ≥100 cm2. We classified the participants into four sarcopenia/obesity groups based on both SMI and VFA. Results The prevalence of SO was 17·8% in men and 24·9% in women. In women, the SO group had higher HOMA- IR and hs CRP levels compared with the non- SO group. In men, the 25[ OH] D levels were significantly lower in the SO group than the non- SO group. Both hs CRP and HOMA- IR levels were negatively correlated with SMI and positively correlated with VFA in both men and women, whereas 25[ OH] D levels were positively correlated with SMI in both men and women. Multiple binary logistic regression analysis showed that HOMA- IR and 25[ OH] D levels were independently associated with SO in men, while HOMA- IR and hs CRP were significant factors predicting SO in women. Conclusion Insulin resistance, inflammation and vitamin D deficiency were associated with SO in a Korean adult population.
- Subjects
KOREA; ENDOCRINOLOGY; OBESITY; INSULIN resistance; VITAMIN D deficiency; SARCOPENIA; C-reactive protein
- Publication
Clinical Endocrinology, 2013, Vol 78, Issue 4, p525
- ISSN
0300-0664
- Publication type
Academic Journal
- DOI
10.1111/j.1365-2265.2012.04433.x