Title: Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism J. Gan et al. Inhibition of repaglinide glucuronidation by gemfibrozil and its glucuronide.
Authors: Gan, Jinping; Chen, Weiqi; Shen, Hong; Gao, Ling; Hong, Yang; Tian, Yuan; Li, Wenying; Zhang, Yueping; Tang, Yuwei; Zhang, Hongjian; Humphreys, William Griffith; Rodrigues, A. David
Abstract: The article presents a study that examines repaglinide and gemfibrozil interactions with or without combination of itraconazole. The study assesses the metabolism, metabolites, and glucuronidation of repaglinide in human liver subcellular fractions, recombinant enzymes, and human hepatocytes. Result shows the ability of repaglinide to directly glucorinade for interaction of gemfibrozil. It adds that repaglinide inhibition halts when gemfribrozil was co-incubated with itraconazole.
Subjects: INSULIN research; DRUG interactions; GLUCURONIDES; LIVER cells; SUBCELLULAR fractionation
Publication: British Journal of Clinical Pharmacology, 2010, Vol 70, Issue 6, p870
ISSN: 0306-5251
Publication type: Academic Journal
DOI: 10.1111/j.1365-2125.2010.03772.x

Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism J. Gan et al. Inhibition of repaglinide glucuronidation by gemfibrozil and its glucuronide.

Gan, Jinping; Chen, Weiqi; Shen, Hong; Gao, Ling; Hong, Yang; Tian, Yuan; Li, Wenying; Zhang, Yueping; Tang, Yuwei; Zhang, Hongjian; Humphreys, William Griffith; Rodrigues, A. David